plos genetics سال:2012 - دوره:8

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plos genetics
سال:2012 - دوره:8 - شماره:7

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation A key role for Chd1 in histone H3 dynamics at the 3′ ends of long genes in yeast A regulatory loop involving PAX6,MITF,and WNT signaling controls retinal pigment epithelium development A trans-species missense SNP in Amhr2 is associated with sex determination in the tiger Pufferfish,Takifugu rubripes (Fugu) Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient Balancing selection at the tomato RCR3 guardee gene family maintains variation in strength of pathogen defense Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2 Cellular variability of RpoS expression underlies subpopulation activation of an integrative and conjugative element Comparative genomics of plant-associated pseudomonas spp.: Insights into diversity and inheritance of traits involved in multitrophic interactions DNA methyltransferases are required to induce heterochromatic re-replication in arabidopsis Detecting individual sites subject to episodic diversifying selection Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival Evidence of inbreeding depression on human height F-box protein specificity for G1 cyclins is dictated by subcellular localization FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response Functional evolution of mammalian odorant receptors GRHL3/GET1 and trithorax group members collaborate to activate the epidermal progenitor differentiation program GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers Gene conversion occurs within the mating-type locus of Cryptococcus neoformans during sexual reproduction Genetic variants in REC8,RNF212,and PRDM9 influence male recombination in cattle Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene Genomic data reveal a complex making of humans Guidelines for genome-wide association studies Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity Histone H2B monoubiquitination facilitates the rapid modulation of gene expression during arabidopsis photomorphogenesis Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways Intact p53-dependent responses in miR-34-deficient mice Large-scale introgression shapes the evolution of the mating-type chromosomes of the filamentous ascomycete Neurospora tetrasperma Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP Lipoproteins in Drosophila melanogaster-assembly,function,and influence on tissue lipid composition Loss of ATRX,genome instability,and an altered DNA damage response are hallmarks of the alternative lengthening of Telomeres pathway Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus OSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM Oocyte family trees: Old branches or new stems? Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation Rapid turnover of long noncoding RNAs and the evolution of gene expression Recent loss of self-incompatibility by degradation of the male component in allotetraploid Arabidopsis kamchatica Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae Role of architecture in the function and specificity of two notch-regulated transcriptional enhancer modules RsFA (YbeB) proteins are conserved ribosomal silencing factors TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans The Arabidopsis HEI10 is a new ZMM protein related to Zip3 The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing The SCFDia2 ubiquitin E3 ligase ubiquitylates Sir4 and functions in transcriptional silencing The chicken frizzle feather is due to an α-Keratin (KRT75) mutation that causes a defective rachis The role of rice HEI10 in the formation of meiotic crossovers The secreted immunoglobulin domain proteins ZIG-5 and ZIG-8 cooperate with L1CAM/SAX-7 to maintain nervous system integrity The three faces of riboviral spontaneous mutation: Spectrum,mode of genome replication,and mutation rate The yeast rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA Three Dopamine pathways induce aversive odor memories with different stability Unmet expectations: MiR-34 plays no role in p53-mediated tumor suppression in vivo WNT16 influences bone mineral density,cortical bone thickness,bone strength,and osteoporotic fracture risk