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DNA methyltransferases are required to induce heterochromatic re-replication in arabidopsis
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نویسنده
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stroud h. ,hale c.j. ,feng s. ,caro e. ,jacob y. ,michaels s.d. ,jacobsen s.e.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 7
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چکیده
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The relationship between epigenetic marks on chromatin and the regulation of dna replication is poorly understood. mutations of the h3k27 methyltransferase genes,arabidopsis trithorax-related protein5 (atxr5) and atxr6,result in re-replication (repeated origin firing within the same cell cycle). here we show that mutations that reduce dna methylation act to suppress the re-replication phenotype of atxr5 atxr6 mutants. this suggests that dna methylation,a mark enriched at the same heterochromatic regions that re-replicate in atxr5/6 mutants,is required for aberrant re-replication. in contrast,rna sequencing analyses suggest that atxr5/6 and dna methylation cooperatively transcriptionally silence transposable elements (tes). hence our results suggest a complex relationship between atxr5/6 and dna methylation in the regulation of dna replication and transcription of tes. © 2012 stroud et al.
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آدرس
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department of molecular,cell,and developmental biology,university of california los angeles,los angeles,ca, United States, department of molecular,cell,and developmental biology,university of california los angeles,los angeles,ca, United States, department of molecular,cell,and developmental biology,university of california los angeles,los angeles,ca, United States, department of molecular,cell,and developmental biology,university of california los angeles,los angeles,ca, United States, department of biology,indiana university,bloomington,in, United States, department of biology,indiana university,bloomington,in, United States, department of molecular,cell,and developmental biology,university of california los angeles,los angeles,ca,united states,howard hughes medical institute,university of california los angeles,los angeles,ca, United States
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Authors
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