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GRHL3/GET1 and trithorax group members collaborate to activate the epidermal progenitor differentiation program
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نویسنده
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hopkin a.s. ,gordon w. ,klein r.h. ,espitia f. ,daily k. ,zeller m. ,baldi p. ,andersen b.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 7
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چکیده
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The antagonistic actions of polycomb and trithorax are responsible for proper cell fate determination in mammalian tissues. in the epidermis,a self-renewing epithelium,previous work has shown that release from polycomb repression only partially explains differentiation gene activation. we now show that trithorax is also a key regulator of epidermal differentiation,not only through activation of genes repressed by polycomb in progenitor cells,but also through activation of genes independent of regulation by polycomb. the differentiation associated transcription factor grhl3/get1 recruits the ubiquitously expressed trithorax complex to a subset of differentiation genes. © 2012 hopkin et al.
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آدرس
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department of biological chemistry,university of california irvine,irvine,ca,united states,department of medicine,university of california irvine,irvine,ca, United States, department of biological chemistry,university of california irvine,irvine,ca,united states,department of medicine,university of california irvine,irvine,ca,united states,center for complex biological systems,university of california irvine,irvine,ca, United States, department of biological chemistry,university of california irvine,irvine,ca,united states,department of medicine,university of california irvine,irvine,ca, United States, department of medicine,university of california irvine,irvine,ca, United States, department of computer science,university of california irvine,irvine,ca, United States, department of computer science,university of california irvine,irvine,ca, United States, center for complex biological systems,university of california irvine,irvine,ca,united states,department of computer science,university of california irvine,irvine,ca, United States, department of biological chemistry,university of california irvine,irvine,ca,united states,department of medicine,university of california irvine,irvine,ca,united states,center for complex biological systems,university of california irvine,irvine,ca, United States
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Authors
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