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Genetic variants in REC8,RNF212,and PRDM9 influence male recombination in cattle
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نویسنده
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sandor c. ,li w. ,coppieters w. ,druet t. ,charlier c. ,georges m.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 7
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چکیده
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We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. we map quantitative trait loci (qtl) influencing genome-wide recombination rate,genome-wide hotspot usage,and locus-specific recombination rate. we fine-map three qtl and present strong evidence that genetic variants in rec8 and rnf212 influence genome-wide recombination rate,while genetic variants in prdm9 influence genome-wide hotspot usage. © 2012 sandor et al.
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آدرس
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unit of animal genomics,giga-r and faculty of veterinary medicine,university of liège,liège,belgium,divisions of genetics and rheumatology,department of medicine,brigham and women's hospital,harvard medical school,boston,ma,united states,program in medical and population genetics,broad institute,cambridge,ma, United States, unit of animal genomics,giga-r and faculty of veterinary medicine,university of liège,liège, Belgium, unit of animal genomics,giga-r and faculty of veterinary medicine,university of liège,liège, Belgium, unit of animal genomics,giga-r and faculty of veterinary medicine,university of liège,liège, Belgium, unit of animal genomics,giga-r and faculty of veterinary medicine,university of liège,liège, Belgium, unit of animal genomics,giga-r and faculty of veterinary medicine,university of liège,liège, Belgium
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Authors
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