plos pathogens سال:2014 - دوره:10

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plos pathogens
سال:2014 - دوره:10 - شماره:5

A Large Family of Antivirulence Regulators Modulates the Effects of Transcriptional Activators in Gram-negative Pathogenic Bacteria A Multifactorial Role for P. falciparum Malaria in Endemic Burkitt's Lymphoma Pathogenesis A Nasal Epithelial Receptor for Staphylococcus aureus WTA Governs Adhesion to Epithelial Cells and Modulates Nasal Colonization A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase A Novel Mechanism Inducing Genome Instability in Kaposi's Sarcoma-Associated Herpesvirus Infected Cells A Role for LHC1 in Higher Order Structure and Complement Binding of the Cryptococcus neoformans Capsule Anthrax Lethal Factor as an Immune Target in Humans and Transgenic Mice and the Impact of HLA Polymorphism on CD4+ T Cell Immunity Are We There Yet? The Smallpox Research Agenda Using Variola Virus BCA2/Rabring7 Targets HIV-1 Gag for Lysosomal Degradation in a Tetherin-Independent Manner Bacterial Superantigens Promote Acute Nasopharyngeal Infection by Streptococcus pyogenes in a Human MHC Class II-Dependent Manner Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response CD8+ T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body Co-assembly of Viral Envelope Glycoproteins Regulates Their Polarized Sorting in Neurons Combined Systems Approaches Reveal Highly Plastic Responses to Antimicrobial Peptide Challenge in Escherichia coli Correction to Rapid Response to Selection,Competitive Release and Increased Transmission Potential of Artesunate-Selected Plasmodium chabaudi Malaria Parasites (PLoS Pathog,(2014),10,5 (e1004184),10.1371/journal.ppat.1004184) Different Modes of Retrovirus Restriction by Human APOBEC3A and APOBEC3G In Vivo Dual-Site Phosphorylation of the Control of Virulence Regulator Impacts Group A Streptococcal Global Gene Expression and Pathogenesis Dynamic Functional Modulation of CD4+ T Cell Recall Responses Is Dependent on the Inflammatory Environment of the Secondary Stimulus Dynamics of HIV Latency and Reactivation in a Primary CD4+ T Cell Model Epigenetic Changes Modulate Schistosome Egg Formation and Are a Novel Target for Reducing Transmission of Schistosomiasis Epstein-Barr Virus Down-Regulates Tumor Suppressor DOK1 Expression Expansion of Murine Gammaherpesvirus Latently Infected B Cells Requires T Follicular Help Follicular Helper T Cells Promote Liver Pathology in Mice during Schistosoma japonicum Infection HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon HIV-1 Envelope gp41 Broadly Neutralizing Antibodies: Hurdles for Vaccine Development HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets,Heightened CD8+ T Cell Activation,and Increased Risk of Non-AIDS Morbidity and Mortality Hepatitis C Virus Cell-Cell Transmission and Resistance to Direct-Acting Antiviral Agents High-Efficiency Targeted Editing of Large Viral Genomes by RNA-Guided Nucleases Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I,II and III Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis Integrative Functional Genomics of Hepatitis C Virus Infection Identifies Host Dependencies in Complete Viral Replication Cycle Large Scale RNAi Reveals the Requirement of Nuclear Envelope Breakdown for Nuclear Import of Human Papillomaviruses Ly49C-Dependent Control of MCMV Infection by NK Cells Is Cis-Regulated by MHC Class I Molecules Malaria Parasite Infection Compromises Control of Concurrent Systemic Non-typhoidal Salmonella Infection via IL-10-Mediated Alteration of Myeloid Cell Function Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses Mycobacterium tuberculosis Hip1 Modulates Macrophage Responses through Proteolysis of GroEL2 New Insights into Rotavirus Entry Machinery: Stabilization of Rotavirus Spike Conformation Is Independent of Trypsin Cleavage PARV4: An Emerging Tetraparvovirus Papillomavirus Genomes Associate with BRD4 to Replicate at Fragile Sites in the Host Genome Phosphorylation of KasB Regulates Virulence and Acid-Fastness in Mycobacterium tuberculosis Prophenoloxidase Activation Is Required for Survival to Microbial Infections in Drosophila Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis Squalene Synthase As a Target for Chagas Disease Therapeutics SslE Elicits Functional Antibodies That Impair In Vitro Mucinase Activity and In Vivo Colonization by Both Intestinal and Extraintestinal Escherichia coli Strains Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented EF-Hand-Like Calcium-Binding Phage Lysin Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection Surveillance for Emerging Biodiversity Diseases of Wildlife T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence TNFα and IFNγ but Not Perforin Are Critical for CD8 T Cell-Mediated Protection against Pulmonary Yersinia pestis Infection Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus The Contribution of Viral Genotype to Plasma Viral Set-Point in HIV Infection The Cytoplasmic Domain of Varicella-Zoster Virus Glycoprotein H Regulates Syncytia Formation and Skin Pathogenesis The Downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 Axis and by Human Cytomegalovirus (HCMV) Associated Factors Allows the Activation of the HCMV Major IE Promoter and the Transition to Productive Infection The Emerging Role of Urease as a General Microbial Virulence Factor The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification The Human Adenovirus E4-ORF1 Protein Subverts Discs Large 1 to Mediate Membrane Recruitment and Dysregulation of Phosphatidylinositol 3-Kinase The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis,Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal Degradation Unexpected Role for IL-17 in Protective Immunity against Hypervirulent Mycobacterium tuberculosis HN878 Infection Venus Kinase Receptors Control Reproduction in the Platyhelminth Parasite Schistosoma mansoni Virus and Autoantigen-Specific CD4+ T Cells Are Key Effectors in a SCID Mouse Model of EBV-Associated Post-Transplant Lymphoproliferative Disorders