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CD8+ T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria
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نویسنده
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lau l.s. ,fernandez-ruiz d. ,mollard v. ,sturm a. ,neller m.a. ,cozijnsen a. ,gregory j.l. ,davey g.m. ,jones c.m. ,lin y.-h. ,haque a. ,engwerda c.r. ,nie c.q. ,hansen d.s. ,murphy k.m. ,papenfuss a.t. ,miles j.j. ,burrows s.r. ,de koning-ward t. ,mcfadden g.i. ,carbone f.r. ,crabb b.s. ,heath w.r.
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منبع
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plos pathogens - 2014 - دوره : 10 - شماره : 5
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چکیده
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To follow the fate of cd8+ t cells responsive to plasmodium berghei anka (pba) infection,we generated an mhc i-restricted tcr transgenic mouse line against this pathogen. t cells from this line,termed pbt-i t cells,were able to respond to blood-stage infection by pba and two other rodent malaria species,p. yoelii xnl and p. chabaudi as. these pbt-i t cells were also able to respond to sporozoites and to protect mice from liver-stage infection. examination of the requirements for priming after intravenous administration of irradiated sporozoites,an effective vaccination approach,showed that the spleen rather than the liver was the main site of priming and that responses depended on cd8α+ dendritic cells. importantly,sequential exposure to irradiated sporozoites followed two days later by blood-stage infection led to augmented pbt-i t cell expansion. these findings indicate that pbt-i t cells are a highly versatile tool for studying multiple stages and species of rodent malaria and suggest that cross-stage reactive cd8+ t cells may be utilized in liver-stage vaccine design to enable boosting by blood-stage infections. © 2014 lau et al.
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آدرس
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department of microbiology and immunology,the peter doherty institute,university of melbourne,parkville,vic, Australia, department of microbiology and immunology,the peter doherty institute,university of melbourne,parkville,vic, Australia, the school of botany,university of melbourne,parkville,vic, Australia, the school of botany,university of melbourne,parkville,vic, Australia, the qimr berghofer medical research institute,brisbane,qld, Australia, the school of botany,university of melbourne,parkville,vic, Australia, department of microbiology and immunology,the peter doherty institute,university of melbourne,parkville,vic, Australia, department of microbiology and immunology,the peter doherty institute,university of melbourne,parkville,vic, Australia, department of microbiology and immunology,the peter doherty institute,university of melbourne,parkville,vic, Australia, department of microbiology and immunology,the peter doherty institute,university of melbourne,parkville,vic, Australia, the qimr berghofer medical research institute,brisbane,qld, Australia, the qimr berghofer medical research institute,brisbane,qld, Australia, the walter and eliza hall institute of medical research,parkville,vic,australia,macfarlane burnet institute for medical research and public health,melbourne,vic, Australia, the walter and eliza hall institute of medical research,parkville,vic, Australia, department of pathology and immunology,washington university school of medicine,st. louis,mo, United States, the walter and eliza hall institute of medical research,parkville,vic, Australia, the qimr berghofer medical research institute,brisbane,qld,australia,school of medicine,the university of queensland,brisbane,qld,australia,institute of infection and immunity,cardiff university school of medicine,heath park,cardiff,wales, United Kingdom, the qimr berghofer medical research institute,brisbane,qld, Australia, school of medicine,deakin university,waurn ponds,vic, Australia, the school of botany,university of melbourne,parkville,vic, Australia, department of microbiology and immunology,the peter doherty institute,university of melbourne,parkville,vic, Australia, department of microbiology and immunology,the peter doherty institute,university of melbourne,parkville,vic,australia,macfarlane burnet institute for medical research and public health,melbourne,vic,australia,monash university,clayton,vic, Australia, department of microbiology and immunology,the peter doherty institute,university of melbourne,parkville,vic,australia,the arc centre of excellence in advanced molecular imaging,university of melbourne,parkville, Australia
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Authors
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