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Follicular Helper T Cells Promote Liver Pathology in Mice during Schistosoma japonicum Infection
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نویسنده
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chen x. ,yang x. ,li y. ,zhu j. ,zhou s. ,xu z. ,he l. ,xue x. ,zhang w. ,dong x. ,wu h. ,li c.j. ,hsu h.-t. ,kong w. ,liu f. ,tripathi p.b. ,yu m.s. ,chang j. ,zhou l. ,su c.
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منبع
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plos pathogens - 2014 - دوره : 10 - شماره : 5
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چکیده
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Following schistosoma japonicum (s. japonicum) infection,granulomatous responses are induced by parasite eggs trapped in host organs,particular in the liver,during the acute stage of disease. while excessive liver granulomatous responses can lead to more severe fibrosis and circulatory impairment in chronically infected host. however,the exact mechanism of hepatic granuloma formation has remained obscure. in this study,we for the first time showed that follicular helper t (tfh) cells are recruited to the liver to upregulate hepatic granuloma formation and liver injury in s. japonicum-infected mice,and identified a novel function of macrophages in tfh cell induction. in addition,our results showed that the generation of tfh cells driven by macrophages is dependent on cell-cell contact and the level of inducible costimulator ligand (icosl) on macrophages which is regulated by cd40-cd40l signaling. our findings uncovered a previously unappreciated role for tfh cells in liver pathology caused by s. japonicum infection in mice. © 2014 chen et al.
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آدرس
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department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu,china,department of pathology,department of microbiology and immunology,feinberg school of medicine,northwestern university,chicago,il, United States, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, department of pediatrics,children's hospital los angeles,los angeles,ca, United States, keck school of medicine of university of southern california,los angeles,ca, United States, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China, keck school of medicine of university of southern california,los angeles,ca, United States, keck school of medicine of university of southern california,los angeles,ca, United States, department of general surgery,kaiser lamc,los angeles,ca, United States, department of pathology,department of microbiology and immunology,feinberg school of medicine,northwestern university,chicago,il, United States, department of pathogen biology and immunology,jiangsu key laboratory of pathogen biology,nanjing medical university,nanjing,jiangsu, China
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Authors
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