plos genetics سال:2012 - دوره:8

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plos genetics
سال:2012 - دوره:8 - شماره:5

A duplication CNV that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and men Abd-A regulation by the iab-8 noncoding RNA Acquisition order of Ras and p53 gene alterations defines distinct adrenocortical tumor phenotypes Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis An essential role for Katanin p80 and microtubule severing in male gamete production Bmps and Id2a act upstream of twist1 to restrict ectomesenchyme potential of the cranial neural crest Chromosome pairing: A hidden treasure no more Collapse of Telomere homeostasis in hematopoietic cells caused by heterozygous mutations in Telomerase genes Common genetic determinants of intraocular pressure and primary open-angle Glaucoma Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo DNA demethylation and USF regulate the meiosis-specific expression of the mouse Miwi Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice Downregulation of chloroplast RPS1 negatively modulates nuclear heat-responsive expression of HsfA2 and its target genes in Arabidopsis Drosophila activated Cdc42 kinase has an anti-apoptotic function Dynamic deposition of histone variant H3.3 accompanies developmental remodeling of the Arabidopsis transcriptome ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice Extent,causes,and consequences of small RNA expression variation in human adipose tissue Fitness landscape transformation through a single Amino acid change in the rho terminator Functional centromeres determine the activation time of pericentric origins of DNA replication in Saccharomyces cerevisiae Genome-wide analysis of GLD-1-mediated mRNA regulation suggests a role in mRNA storage Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women Genome-wide association of pericardial fat identifies a unique locus for Ectopic fat Genome-wide copy number analysis uncovers a new HSCR gene: NRG3 Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome Histone H1 depletion impairs embryonic stem cell differentiation Histone H3 localizes to the centromeric DNA in budding yeast Hypersensitive to red and blue 1 and its modification by protein phosphatase 7 are implicated in the control of arabidopsis stomatal aperture IDN2 and its paralogs form a complex required for RNA-directed DNA methylation Identification of genes that promote or antagonize somatic homolog pairing using a high-throughput FISH-based screen Inactivation of a novel FGF23 regulator,FAM20C,leads to hypophosphatemic rickets in mice Integrin α PAT-2/CDC-42 signaling is required for muscle-mediated clearance of apoptotic cells in Caenorhabditis elegans KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility Karyotypic determinants of chromosome instability in Aneuploid budding yeast Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations LINT,a novel dL(3)mbt-containing complex,represses malignant brain tumour signature genes Loss of Gnas imprinting differentially affects REM/NREM sleep and cognition in mice Meiotic chromosome pairing is promoted by telomere-led chromosome movements independent of bouquet formation MicroRNA-277 modulates the neurodegeneration caused by fragile X premutation rCGG repeats Neurospora COP9 signalosome integrity plays major roles for hyphal growth,conidial development,and circadian function New insight into the history of domesticated apple: Secondary contribution of the European wild apple to the genome of cultivated varieties Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone Principles of Carbon Catabolite repression in the rice blast fungus: Tps1,Nmr1-3,and a MATE-family pump regulate glucose metabolism during infection Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality Recombination drives vertebrate genome contraction Regulating repression: Roles for the Sir4 N-terminus in linker DNA protection and stabilization of epigenetic states Repeated,selection-driven genome reduction of accessory genes in experimental populations Scientist citizen: An interview with Bruce Alberts Separation of DNA replication from the assembly of break-competent meiotic chromosomes Six novel susceptibility loci for early-onset androgenetic alopecia and their unexpected association with common diseases Slowing replication in preparation for reduction Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases TBC-8,a putative RAB-2 GAP,regulates dense core vesicle maturation in Caenorhabditis elegans Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a down syndrome mouse model The C. elegans H3K27 demethylase UTX-1 is essential for normal development,independent of its enzymatic activity The number of X chromosomes causes sex differences in adiposity in mice Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis UDP-Galactose 4′-epimerase activities toward UDP-Gal and UDP-GaLNAc play different roles in the development of Drosophila melanogaster Using whole-genome sequence data to predict quantitative trait phenotypes in Drosophila melanogaster YY1 regulates melanocyte development and function by cooperating with MITF