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Abd-A regulation by the iab-8 noncoding RNA
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نویسنده
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gummalla m. ,maeda r.k. ,alvarez j.j. ,gyurkovics h. ,singari s. ,edwards k.a. ,karch f. ,bender w.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 5
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چکیده
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The homeotic genes in drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. the genes affecting the more posterior segments repress the more anterior genes. this posterior dominance rule must be qualified in the case of abdominal-a (abd-a) repression by abdominal-b (abd-b). animals lacking abd-b show ectopic expression of abd-a in the epidermis of the eighth abdominal segment,but not in the central nervous system. repression in these neuronal cells is accomplished by a 92 kb noncoding rna. this iab-8 rna produces a micro rna to repress abd-a,but also has a second,redundant repression mechanism that acts only in cis. transcriptional interference with the abd-a promoter is the most likely mechanism. © 2012 gummalla et al.
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آدرس
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department of genetics and evolution,university of geneva,geneva, Switzerland, department of genetics and evolution,university of geneva,geneva, Switzerland, department of genetics and evolution,university of geneva,geneva, Switzerland, institute of genetics,biological research center,szeged, Hungary, school of biological sciences,illinois state university,normal,il, United States, school of biological sciences,illinois state university,normal,il, United States, department of genetics and evolution,university of geneva,geneva, Switzerland, department of biological chemistry and molecular pharmacology,harvard medical school,boston,ma, United States
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Authors
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