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Genome-wide association of pericardial fat identifies a unique locus for Ectopic fat
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نویسنده
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fox c.s. ,white c.c. ,lohman k. ,heard-costa n. ,cohen p. ,zhang y. ,johnson a.d. ,emilsson v. ,liu c.-t. ,chen y.-d.i. ,taylor k.d. ,allison m. ,budoff m. ,rotter j.i. ,carr j.j. ,hoffmann u. ,ding j. ,cupples l.a. ,liu y.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 5
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چکیده
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Pericardial fat is a localized fat depot associated with coronary artery calcium and myocardial infarction. we hypothesized that genetic loci would be associated with pericardial fat independent of other body fat depots. pericardial fat was quantified in 5,487 individuals of european ancestry from the framingham heart study (fhs) and the multi-ethnic study of atherosclerosis (mesa). genotyping was performed using standard arrays and imputed to ~2.5 million hapmap snps. each study performed a genome-wide association analysis of pericardial fat adjusted for age,sex,weight,and height. a weighted z-score meta-analysis was conducted,and validation was obtained in an additional 3,602 multi-ethnic individuals from the mesa study. we identified a genome-wide significant signal in our primary meta-analysis at rs10198628 near trib2 (maf 0.49,p = 2.7×10-08). this snp was not associated with visceral fat (p = 0.17) or body mass index (p = 0.38),although we observed direction-consistent,nominal significance with visceral fat adjusted for bmi (p = 0.01) in the framingham heart study. our findings were robust among african ancestry (n = 1,442,p = 0.001),hispanic (n = 1,399,p = 0.004),and chinese (n = 761,p = 0.007) participants from the mesa study,with a combined p-value of 5.4e-14. we observed trib2 gene expression in the pericardial fat of mice. rs10198628 near trib2 is associated with pericardial fat but not measures of generalized or visceral adiposity,reinforcing the concept that there are unique genetic underpinnings to ectopic fat distribution.
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آدرس
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framingham heart study,national heart,lung,and blood institute,framingham,ma,united states,center for population studies,national heart,lung,and blood institute,framingham,ma,united states,division of endocrinology,brigham and women's hospital and harvard medical school,boston,ma, United States, framingham heart study,national heart,lung,and blood institute,framingham,ma,united states,department of biostatistics,boston university school of public health,boston,ma, United States, department of epidemiology and prevention,public health sciences,wake forest school of medicine,winston-salem,nc, United States, department of neurology,boston university school of medicine,boston,ma, United States, division of cardiovascular medicine and department of cancer biology,brigham and women's hospital and dana farber cancer institute,boston,ma, United States, department of cancer biology,dana farber cancer institute,boston,ma, United States, framingham heart study,national heart,lung,and blood institute,framingham,ma,united states,center for population studies,national heart,lung,and blood institute,framingham,ma, United States, icelandic heart association,hjartavernd, Iceland, framingham heart study,national heart,lung,and blood institute,framingham,ma,united states,department of biostatistics,boston university school of public health,boston,ma, United States, medical genetics institute,cedars-sinai medical center,los angeles,ca, United States, medical genetics institute,cedars-sinai medical center,los angeles,ca, United States, department of preventive medicine,university of california san diego,la jolla,ca, United States, los angeles biomedical research institute,torrance,ca, United States, medical genetics institute,cedars-sinai medical center,los angeles,ca, United States, departments of radiologic sciences,internal medicine-cardiology,and public health sciences,wake forest university school of medicine,winston-salem,nc, United States, cardiac mr,pet,ct program,the department of radiology,massachusetts general hospital,boston,ma, United States, department of internal medicine/geriatrics,wake forest school of medicine,winston-salem,nc, United States, framingham heart study,national heart,lung,and blood institute,framingham,ma,united states,department of biostatistics,boston university school of public health,boston,ma, United States, department of epidemiology and prevention,public health sciences,wake forest school of medicine,winston-salem,nc, United States
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Authors
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