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YY1 regulates melanocyte development and function by cooperating with MITF
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نویسنده
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li j. ,song j.s. ,bell r.j.a. ,tran t.-n.t. ,haq r. ,liu h. ,love k.t. ,langer r. ,anderson d.g. ,larue l. ,fisher d.e.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 5
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چکیده
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Studies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. here,we generated yy1 conditional knockout mice in the melanocyte-lineage and observed profound melanocyte deficiency and premature gray hair,similar to the loss of melanocytes in human piebaldism and waardenburg syndrome. although yy1 is a ubiquitous transcription factor,yy1 interacts with m-mitf,the waardenburg syndrome iia gene and a master transcriptional regulator of melanocytes. yy1 cooperates with m-mitf in regulating the expression of piebaldism gene kit and multiple additional pigmentation genes. moreover,chip-seq identified genome-wide yy1 targets in the melanocyte lineage. these studies mechanistically link genes implicated in human conditions of melanocyte deficiency and reveal how a ubiquitous factor (yy1) gains lineage-specific functions by co-regulating gene expression with a lineage-restricted factor (m-mitf)-a general mechanism which may confer tissue-specific gene expression in multiple lineages. © 2012 li et al.
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آدرس
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department of dermatology,cutaneous biology research center,massachusetts general hospital,harvard medical school,boston,ma, United States, institute for human genetics,university of california san francisco,san francisco,ca,united states,department of epidemiology and biostatistics,department of bioengineering and therapeutic sciences,the eli and edythe broad center of regeneration medicine and stem cell research,university of california san francisco,san francisco,ca, United States, institute for human genetics,university of california san francisco,san francisco,ca, United States, department of dermatology,cutaneous biology research center,massachusetts general hospital,harvard medical school,boston,ma, United States, department of dermatology,cutaneous biology research center,massachusetts general hospital,harvard medical school,boston,ma,united states,division of medical oncology,massachusetts general hospital,boston,ma, United States, children's hospital boston,harvard medical school,boston,ma, United States, department of chemical engineering,massachusetts institute of technology,cambridge,ma, United States, department of chemical engineering,massachusetts institute of technology,cambridge,ma,united states,david h. koch institute for integrative cancer research,massachusetts institute of technology,cambridge,ma,united states,harvard-mit division of health sciences and technology,cambridge,ma, United States, department of chemical engineering,massachusetts institute of technology,cambridge,ma,united states,david h. koch institute for integrative cancer research,massachusetts institute of technology,cambridge,ma,united states,harvard-mit division of health sciences and technology,cambridge,ma, United States, institut curie,developmental genetics of melanocytes,u1021 inserm,umr 3347 cnrs,orsay, France, department of dermatology,cutaneous biology research center,massachusetts general hospital,harvard medical school,boston,ma, United States
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Authors
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