plos genetics سال:2013 - دوره:9

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plos genetics
سال:2013 - دوره:9 - شماره:2

A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function A Regulatory Pathway,Ecdysone-Transcription Factor Relish-Cathepsin L,Is Involved in Insect Fat Body Dissociation A Retrotransposon Insertion in the 5′ Regulatory Domain of Ptf1a Results in Ectopic Gene Expression and Multiple Congenital Defects in Danforth's Short Tail Mouse Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis,Inflammation,and Autoantibody Production Age-Dependent Transition from Cell-Level to Population-Level Control in Murine Intestinal Homeostasis Revealed by Coalescence Analysis Altered Cohesin Gene Dosage Affects Mammalian Meiotic Chromosome Structure and Behavior An Evolutionary Perspective on Epistasis and the Missing Heritability Ancient DNA Reveals Prehistoric Gene-Flow from Siberia in the Complex Human Population History of North East Europe Antagonism Versus Cooperativity with TALE Cofactors at the Base of the Functional Diversification of Hox Protein Function Assembly of the Auditory Circuitry by a Hox Genetic Network in the Mouse Brainstem Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis CELF Family RNA-Binding Protein UNC-75 Regulates Two Sets of Mutually Exclusive Exons of the unc-32 Gene in Neuron-Specific Manners in Caenorhabditis elegans COM-1 Promotes Homologous Recombination during Caenorhabditis elegans Meiosis by Antagonizing Ku-Mediated Non-Homologous End Joining Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets Comment on Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome Complex Inheritance of Melanoma and Pigmentation of Coat and Skin in Grey Horses Conditional Inactivation of the DNA Damage Response Gene Hus1 in Mouse Testis Reveals Separable Roles for Components of the RAD9-RAD1-HUS1 Complex in Meiotic Chromosome Maintenance Confounding by Repetitive Elements and CpG Islands Does Not Explain the Association between Hypomethylation and Genomic Instability Control of Multicellular Development by the Physically Interacting Deneddylases DEN1/DenA and COP9 Signalosome Coordination of Chromatid Separation and Spindle Elongation by Antagonistic Activities of Mitotic and S-Phase CDKs DNA Methylation Mediated Control of Gene Expression Is Critical for Development of Crown Gall Tumors DNA-Methylome Analysis of Mouse Intestinal Adenoma Identifies a Tumour-Specific Signature That Is Partly Conserved in Human Colon Cancer Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency Discovery of a Splicing Regulator Required for Cell Cycle Progression Drosophila Yemanuclein and HIRA Cooperate for De Novo Assembly of H3.3-Containing Nucleosomes in the Male Pronucleus Duplicate Abalone Egg Coat Proteins Bind Sperm Lysin Similarly,but Evolve Oppositely,Consistent with Molecular Mimicry at Fertilization Dynamic Association of NUP98 with the Human Genome Ectopic Expression of Ptf1a Induces Spinal Defects,Urogenital Defects,and Anorectal Malformations in Danforth's Short Tail Mice Ehd4 Encodes a Novel and Oryza-Genus-Specific Regulator of Photoperiodic Flowering in Rice Essential Developmental,Genomic Stability,and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2 Expression of a Novel P22 ORFan Gene Reveals the Phage Carrier State in Salmonella Typhimurium FAM20A Mutations Can Cause Enamel-Renal Syndrome (ERS) Gene-Based Testing of Interactions in Association Studies of Quantitative Traits Genetic Determinants of Trabecular and Cortical Volumetric Bone Mineral Densities and Bone Microstructure Genetic Landscape of Open Chromatin in Yeast Genome-Wide Analysis Points to Roles for Extracellular Matrix Remodeling,the Visual Cycle,and Neuronal Development in Myopia Genome-Wide Diversity in the Levant Reveals Recent Structuring by Culture Hepatocyte Growth Factor,a Determinant of Airspace Homeostasis in the Murine Lung ISWI and CHD Chromatin Remodelers Bind Promoters but Act in Gene Bodies Identification of the SlmA Active Site Responsible for Blocking Bacterial Cytokinetic Ring Assembly over the Chromosome ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-β Signaling JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes Lessons from Dwarf8 on the Strengths and Weaknesses of Structured Association Mapping MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice Massive Mitochondrial Gene Transfer in a Parasitic Flowering Plant Clade Mechanisms Involved in the Functional Divergence of Duplicated GroEL Chaperonins in Myxococcus xanthus DK1622 MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families Next-Generation Sequencing Identifies the Danforth's Short Tail Mouse Mutation as a Retrotransposon Insertion Affecting Ptf1a Expression Only One Isoform of Drosophila melanogaster CTP Synthase Forms the Cytoophidium Patterning of Leaf Vein Networks by Convergent Auxin Transport Pathways PcG-Mediated Higher-Order Chromatin Structures Modulate Replication Programs at the Drosophila BX-C Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci Polygenic Modeling with Bayesian Sparse Linear Mixed Models Properties and Modeling of GWAS when Complex Disease Risk Is Due to Non-Complementing,Deleterious Mutations in Genes of Large Effect Quantitative Analysis of Histone Modifications: Formaldehyde Is a Source of Pathological N6-Formyllysine That Is Refractory to Histone Deacetylases RNAi-Based Functional Profiling of Loci from Blood Lipid Genome-Wide Association Studies Identifies Genes with Cholesterol-Regulatory Function Rearrangements of 2.5 Kilobases of Noncoding DNA from the Drosophila even-skipped Locus Define Predictive Rules of Genomic cis-Regulatory Logic Regulation of Drosophila Metamorphosis by Xenobiotic Response Regulators Regulation of Neurod1 Contributes to the Lineage Potential of Neurogenin3+ Endocrine Precursor Cells in the Pancreas Retrotransposon Activates Ectopic Ptf1 Expression: A Short Tail Roles of the Developmental Regulator unc-62/Homothorax in Limiting Longevity in Caenorhabditis elegans SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State Single Transmembrane Peptide DinQ Modulates Membrane-Dependent Activities The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6,a Gene Identified through Mining the DPH1-DPH5 Interaction Network The Archipelago Ubiquitin Ligase Subunit Acts in Target Tissue to Restrict Tracheal Terminal Cell Branching and Hypoxic-Induced Gene Expression The Caenorhabditis elegans JNK Signaling Pathway Activates Expression of Stress Response Genes by Derepressing the Fos/HDAC Repressor Complex The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR-Mediated Double-Strand Break Repair The Mub1/Ubr2 Ubiquitin Ligase Complex Regulates the Conserved Dsn1 Kinetochore Protein The Prefoldin Bud27 Mediates the Assembly of the Eukaryotic RNA Polymerases in an Rpb5-Dependent Manner Transposon Variants and Their Effects on Gene Expression in Arabidopsis Tysnd1 Deficiency in Mice Interferes with the Peroxisomal Localization of PTS2 Enzymes,Causing Lipid Metabolic Abnormalities and Male Infertility miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1