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Essential Developmental,Genomic Stability,and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2
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نویسنده
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shi w. ,bain a.l. ,schwer b. ,al-ejeh f. ,smith c. ,wong l. ,chai h. ,miranda m.s. ,ho u. ,kawaguchi m. ,miura y. ,finnie j.w. ,wall m. ,heierhorst j. ,wicking c. ,spring k.j. ,alt f.w. ,khanna k.k.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 2
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چکیده
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Single-stranded dna binding proteins (ssbs) regulate multiple dna transactions,including replication,transcription,and repair. we recently identified ssb1 as a novel protein critical for the initiation of atm signaling and dna double-strand break repair by homologous recombination. here we report that germline ssb1-/- embryos die at birth from respiratory failure due to severe rib cage malformation and impaired alveolar development,coupled with additional skeletal defects. unexpectedly,ssb1-/- fibroblasts did not exhibit defects in atm signaling or γ-h2ax focus kinetics in response to ionizing radiation (ir),and b-cell specific deletion of ssb1 did not affect class-switch recombination in vitro. however,conditional deletion of ssb1 in adult mice led to increased cancer susceptibility with broad tumour spectrum,impaired male fertility with testicular degeneration,and increased radiosensitivity and ir-induced chromosome breaks in vivo. collectively,these results demonstrate essential roles of ssb1 in embryogenesis,spermatogenesis,and genome stability in vivo. © 2013 shi et al.
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آدرس
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queensland institute of medical research,herston, Australia, queensland institute of medical research,herston,australia,school of biomolecular and physical sciences,griffith university,nathan, Australia, howard hughes medical institute,immune disease institute,program in cellular and molecular medicine,children's hospital boston,boston,ma,united states,department of genetics and pediatrics,harvard medical school,boston,ma, United States, queensland institute of medical research,herston, Australia, queensland institute of medical research,herston, Australia, department of biochemistry and molecular biology,school of biomedical sciences,monash university,melbourne, Australia, howard hughes medical institute,immune disease institute,program in cellular and molecular medicine,children's hospital boston,boston,ma,united states,department of genetics and pediatrics,harvard medical school,boston,ma, United States, queensland institute of medical research,herston,australia,school of medicine,university of queensland,herston, Australia, queensland institute of medical research,herston, Australia, department of bioregulation and molecular neurobiology,nagoya city university,graduate school of medical sciences,nagoya, Japan, department of bioregulation and molecular neurobiology,nagoya city university,graduate school of medical sciences,nagoya, Japan, sa pathology,institute of medical and veterinary science,adelaide, Australia, victorian cancer cytogenetics service,st. vincent's hospital,fitzroy,melbourne,australia,department of medicine,st. vincent's hospital,fitzroy, Australia, department of medicine,st. vincent's hospital,fitzroy,australia,st. vincent's institute,fitzroy, Australia, institute for molecular bioscience,the university of queensland,st. lucia, Australia, queensland institute of medical research,herston,australia,school of biomolecular and physical sciences,griffith university,nathan,australia,school of medicine,university of queensland,herston, Australia, howard hughes medical institute,immune disease institute,program in cellular and molecular medicine,children's hospital boston,boston,ma,united states,department of genetics and pediatrics,harvard medical school,boston,ma, United States, queensland institute of medical research,herston,australia,school of biomolecular and physical sciences,griffith university,nathan,australia,school of medicine,university of queensland,herston, Australia
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Authors
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