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ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy
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نویسنده
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faraco j. ,lin l. ,kornum b.r. ,kenny e.e. ,trynka g. ,einen m. ,rico t.j. ,lichtner p. ,dauvilliers y. ,arnulf i. ,lecendreux m. ,javidi s. ,geisler p. ,mayer g. ,pizza f. ,poli f. ,plazzi g. ,overeem s. ,lammers g.j. ,kemlink d. ,sonka k. ,nevsimalova s. ,rouleau g. ,desautels a. ,montplaisir j. ,frauscher b. ,ehrmann l. ,högl b. ,jennum p. ,bourgin p. ,peraita-adrados r. ,iranzo a. ,bassetti c. ,chen w.-m. ,concannon p. ,thompson s.d. ,damotte v. ,fontaine b. ,breban m. ,gieger c. ,klopp n. ,deloukas p. ,wijmenga c. ,hallmayer j. ,onengut-gumuscu s. ,rich s.s. ,winkelmann j. ,mignot e.
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منبع
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plos genetics - 2013 - دوره : 9 - شماره : 2
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چکیده
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Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency. we genotyped loci associated with other autoimmune and inflammatory diseases in 1,886 individuals with hypocretin-deficient narcolepsy and 10,421 controls,all of european ancestry,using a custom genotyping array (immunochip). three loci located outside the human leukocyte antigen (hla) region on chromosome 6 were significantly associated with disease risk. in addition to a strong signal in the t cell receptor alpha (tra@),variants in two additional narcolepsy loci,cathepsin h (ctsh) and tumor necrosis factor (ligand) superfamily member 4 (tnfsf4,also called ox40l),attained genome-wide significance. these findings underline the importance of antigen presentation by hla class ii to t cells in the pathophysiology of this autoimmune disease. © 2013 faraco et al.
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آدرس
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center for sleep sciences and medicine,stanford university,palo alto,ca, United States, center for sleep sciences and medicine,stanford university,palo alto,ca, United States, center for sleep sciences and medicine,stanford university,palo alto,ca,united states,center for sleep medicine,department of clinical neurophysiology,faculty of health sciences,university of copenhagen,glostrup hospital,copenhagen, Denmark, department of genetics,stanford university,palo alto,ca, United States, university of groningen,university medical center groningen,department of genetics,groningen, Netherlands, center for sleep sciences and medicine,stanford university,palo alto,ca, United States, center for sleep sciences and medicine,stanford university,palo alto,ca, United States, institute of human genetics,helmholtz zentrum münchen-german research center for environmental health,munich, Germany, national reference network for orphan diseases (narcolepsy and idiopathic hypersomnia),paris,france,sleep unit,gui-de-chauliac hospital,inserm-1061,montpellier, France, national reference network for orphan diseases (narcolepsy and idiopathic hypersomnia),paris,france,sleep disorders unit,hospital pitié-salpêtrière,pierre and marie curie university,paris, France, national reference network for orphan diseases (narcolepsy and idiopathic hypersomnia),paris,france,centre pédiatrique des pathologies du sommeil,hôpital robert debré,paris, France, hephata-klinik,schwalmstadt-treysa,germany,department of neurology,philipps university of marburg,marburg, Germany, department of psychiatry and psychotherapy,university of regensburg,regensburg, Germany, hephata-klinik,schwalmstadt-treysa,germany,department of neurology,philipps university of marburg,marburg, Germany, department of neurological sciences,university of bologna/irccs istituto delle scienze neurologiche,bologna, Italy, department of neurological sciences,university of bologna/irccs istituto delle scienze neurologiche,bologna, Italy, center for sleep sciences and medicine,stanford university,palo alto,ca,united states,department of neurological sciences,university of bologna/irccs istituto delle scienze neurologiche,bologna, Italy, kempenhaeghe centre for sleep medicine,heeze, Netherlands, leiden university medical center,department of neurology,leiden university medical center,leiden, Netherlands, department of neurology,charles university,1st faculty of medicine and general teaching hospital,prague, Czech Republic, department of neurology,charles university,1st faculty of medicine and general teaching hospital,prague, Czech Republic, department of neurology,charles university,1st faculty of medicine and general teaching hospital,prague, Czech Republic, chu ste-justine research centre,centre of excellence in neuromics,université de montréal (cenum),montreal,qc, Canada, neurology service,hôpital du sacré-coeur,université de montréal,montréal,qc,canada,center for advanced research in sleep medicine,hôpital du sacré-cœur,université de montréal,montréal,qc, Canada, center for advanced research in sleep medicine,hôpital du sacré-cœur,université de montréal,montréal,qc, Canada, department of neurology,innsbruck medical university,innsbruck, Austria, department of neurology,innsbruck medical university,innsbruck, Austria, department of neurology,innsbruck medical university,innsbruck, Austria, center for sleep medicine,department of clinical neurophysiology,faculty of health sciences,university of copenhagen,glostrup hospital,copenhagen, Denmark, university sleep clinic and cnrs upr3212,strasbourg university hospital,strasbourg university,strasbourg, France, sleep and epilepsy unit-clinical neurophysiology service,university hospital gregorio marañón,madrid, Spain, neurology service and multisciplinary sleep unit,hospital clínic,ciberned,idibaps,barcelona, Spain, department of neurology,inselspital universitatsspital,bern, Switzerland, center for public health genomics,university of virginia,charlottesville,va, United States, center for public health genomics,university of virginia,charlottesville,va, United States, division of rheumatology,cincinnati children's hospital medical center,cincinnati,oh, United States, inserm,u975,cricm,paris,france,pierre marie curie university,umr-s975,paris, France, inserm,u975,cricm,paris,france,pierre marie curie university,umr-s975,paris,france,assistance publique-hôpitaux de paris,department of neurology,hospital pitié-salpêtrière,paris, France, cochin institute,inserm u1016/cnrs umr 8104/paris descartes university,paris,france,department of rheumatology,ambroise paré hospital ap-hp,boulogne-billancourt,france,université versailles saint quentin en yvelines (uvsq),boulogne-billancourt, France, institute of genetic epidemiology,helmholtz zentrum münchen,munich, Germany, institute of genetic epidemiology,helmholtz zentrum münchen,munich, Germany, wellcome trust sanger institute,hinxton, United Kingdom, university of groningen,university medical center groningen,department of genetics,groningen, Netherlands, center for sleep sciences and medicine,stanford university,palo alto,ca,united states,department of psychiatry,stanford university school of medicine,palo alto,ca, United States, center for public health genomics,university of virginia,charlottesville,va, United States, center for public health genomics,university of virginia,charlottesville,va, United States, institute of human genetics,helmholtz zentrum münchen-german research center for environmental health,munich,germany,institute for human genetics,klinikum rechts der isar,technische universität münchen,munich,germany,neurology clinic,klinikum rechts der isar,technische universität münchen,munich,germany,munich cluster for systems neurology (synergy),munich, Germany, center for sleep sciences and medicine,stanford university,palo alto,ca, United States
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