plos genetics سال:2011 - دوره:7

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plos genetics
سال:2011 - دوره:7 - شماره:4

14-3-3 proteins regulate exonuclease 1-dependent processing of stalled replication forks A large-scale complex haploinsufficiency-based genetic interaction screen in candida albicans: Analysis of the ram network during morphogenesis A sustained dietary change increases epigenetic variation in isogenic mice Adaptations to climate-mediated selective pressures in humans Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in g2 cells lacking ap endonuclease An evolutionary genomic approach to identify genes involved in human birth timing Arabidopsis hda6 regulates locus-directed heterochromatin silencing in cooperation with met1 Beyond missing heritability: Prediction of complex traits Chromatin organization in sperm may be the major functional consequence of base composition variation in the human genome DNA damage,somatic aneuploidy,and malignant sarcoma susceptibility in muscular dystrophies Deficiency of huntingtin has pleiotropic effects in the social amoeba dictyostelium discoideum Does positive selection drive transcription factor binding site turnover? a test with drosophila cis-regulatory modules Dynamic regulation of H3K27 trimethylation during arabidopsis differentiation ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25.1 Eight common genetic variants associated with serum dheas levels suggest a key role in ageing mechanisms Enhanced statistical tests for GWAS in admixed populations: Assessment using african americans from CARe and a breast cancer consortium Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium Evolution meets disease: Penetrance and functional epistasis of mitochondrial tRNA mutations Evolution of vertebrate transient receptor potential vanilloid 3 channels: Opposite temperature sensitivity between mammals and western clawed frogs Fluctuations in spo0A transcription control rare developmental transitions in bacillus subtilis GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma Genome analysis reveals interplay between 5′UTR introns and nuclear mRNA export for secretory and mitochondrial genes Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK,PNPLA3,RELA,and SH2B3 loci Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption Genomic instability,defective spermatogenesis,immunodeficiency,and cancer in a mouse model of the RIDDLE syndrome Highly precise and developmentally programmed genome assembly in paramecium requires ligase IV-dependent end joining Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in plasmodium falciparum Incorporating biological pathways via a markov random field model in genome-wide association studies Long-lost relative claims orphan gene: Oskar in a wasp Loss-of-function mutations in PTPN11 cause metachondromatosis,but not ollier disease or maffucci syndrome Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis Nk cell receptor/H2-Dk-dependent host resistance to viral infection is quantitatively modulated by H2q inhibitory signals PDP-1 links the TGF-β and IIS pathways to regulate longevity,development,and metabolism PTG depletion removes lafora bodies and rescues the fatal epilepsy of lafora disease Phosphorylation-dependent differential regulation of plant growth,cell death,and innate immunity by the regulatory receptor-like kinase BAK1 Protein phosphatase 2A controls ethylene biosynthesis by differentially regulating the turnover of ACC synthase isoforms Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape Ribosomal dna deletions modulate genome-wide gene expression: rDNA-sensitive genes and natural variation Survival motor neuron protein regulates stem cell division,proliferation,and differentiation in drosophila The complete spectrum of yeast chromosome instability genes identifies candidate cin cancer genes and functional roles for astra complex components The exocyst protein sec10 interacts with polycystin-2 and knockdown causes PKD-phenotypes The history of african gene flow into Southern Europeans,Levantines,and Jews The liberation of embryonic stem cells The phylogenetic origin of oskar coincided with the origin of maternally provisioned germ plasm and pole cells at the base of the holometabola Tissue-autonomous function of drosophila seipin in preventing ectopic lipid droplet formation Towards establishment of a rice stress response interactome Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia Variable pathogenicity determines individual lifespan in caenorhabditis elegans