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Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
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نویسنده
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cornelis m.c. ,monda k.l. ,yu k. ,paynter n. ,azzato e.m. ,bennett s.n. ,berndt s.i. ,boerwinkle e. ,chanock s. ,chatterjee n. ,couper d. ,curhan g. ,heiss g. ,hu f.b. ,hunter d.j. ,jacobs k. ,jensen m.k. ,kraft p. ,landi m.t. ,nettleton j.a. ,purdue m.p. ,rajaraman p. ,rimm e.b. ,rose l.m. ,rothman n. ,silverman d. ,stolzenberg-solomon r. ,subar a. ,yeager m. ,chasman d.i. ,van dam r.m. ,caporaso n.e.
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منبع
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plos genetics - 2011 - دوره : 7 - شماره : 4
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چکیده
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We report the first genome-wide association study of habitual caffeine intake. we included 47,341 individuals of european descent based on five population-based studies within the united states. in a meta-analysis adjusted for age,sex,smoking,and eigenvectors of population variation,two loci achieved genome-wide significance: 7p21 (p = 2.4×10-19),near ahr,and 15q24 (p = 5.2×10-14),between cyp1a1 and cyp1a2. both the ahr and cyp1a2 genes are biologically plausible candidates as cyp1a2 metabolizes caffeine and ahr regulates cyp1a2.
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آدرس
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department of nutrition,harvard school of public health,boston,ma, United States, department of epidemiology,the university of north carolina at chapel hill,chapel hill,nc, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, brigham and women's hospital,boston,ma, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, collaborative health studies coordinating center,university of washington,seattle,wa, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, division of epidemiology,human genetics,and environmental sciences,the university of texas health science center at houston,houston,tx, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, department of biostatistics,collaborative studies coordinating center,the university of north carolina at chapel hill,chapel hill,nc, United States, brigham and women's hospital,harvard medical school,boston,ma, United States, department of epidemiology,the university of north carolina at chapel hill,chapel hill,nc, United States, department of nutrition,harvard school of public health,boston,ma, United States, department of nutrition,harvard school of public health,boston,ma, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, department of nutrition,harvard school of public health,boston,ma, United States, program in molecular and genetic epidemiology,harvard school of public health,boston,ma, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, division of epidemiology,human genetics,and environmental sciences,the university of texas health science center at houston,houston,tx, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, department of nutrition,harvard school of public health,boston,ma, United States, brigham and women's hospital,boston,ma, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, brigham and women's hospital,boston,ma, United States, department of epidemiology and public health and department of medicine,yong loo lin school of medicine,national university of singapore,singapore, Singapore, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States
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Authors
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