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Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK,PNPLA3,RELA,and SH2B3 loci
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نویسنده
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paré g. ,ridker p.m. ,rose l. ,barbalic m. ,dupuis j. ,dehghan a. ,bis j.c. ,benjamin e.j. ,shiffman d. ,parker a.n. ,chasman d.i.
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منبع
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plos genetics - 2011 - دوره : 7 - شماره : 4
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چکیده
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Soluble icam-1 (sicam-1) is an endothelium-derived inflammatory marker that has been associated with diverse conditions such as myocardial infarction,diabetes,stroke,and malaria. despite evidence for a heritable component to sicam-1 levels,few genetic loci have been identified so far. to comprehensively address this issue,we performed a genome-wide association analysis of sicam-1 concentration in 22,435 apparently healthy women from the women's genome health study. while our results confirm the previously reported associations at the abo and icam1 loci,four novel associations were identified in the vicinity of nfkbik (rs3136642,p = 5.4×10-9),pnpla3 (rs738409,p = 5.8×10-9),rela (rs1049728,p = 2.7×10-16),and sh2b3 (rs3184504,p = 2.9×10-17). two loci,nfkbib and rela,are involved in nfkb signaling pathway; pnpla3 is known for its association with fatty liver disease; and sh3b2 has been associated with a multitude of traits and disease including myocardial infarction. these associations provide insights into the genetic regulation of sicam-1 levels and implicate these loci in the regulation of endothelial function. © 2011 paré et al.
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آدرس
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center for cardiovascular disease prevention,brigham and women's hospital,harvard medical school,boston,ma,united states,donald w. reynolds center for cardiovascular research,brigham and women's hospital,harvard medical school,boston,ma,united states,mcmaster university,hamilton, Canada, center for cardiovascular disease prevention,brigham and women's hospital,harvard medical school,boston,ma,united states,donald w. reynolds center for cardiovascular research,brigham and women's hospital,harvard medical school,boston,ma, United States, center for cardiovascular disease prevention,brigham and women's hospital,harvard medical school,boston,ma,united states,donald w. reynolds center for cardiovascular research,brigham and women's hospital,harvard medical school,boston,ma, United States, human genetics center and institute of molecular medicine,university of texas health science center at houston,houston,tx, United States, national heart,lung,and blood institute's and boston university's framingham heart study,framingham,ma,united states,department of biostatistics,boston university school of public health,boston,ma, United States, department of epidemiology,erasmus medical center,rotterdam,netherlands,the netherlands consortium on healthy aging (ncha),leiden, Netherlands, cardiovascular health research unit,department of medicine,university of washington,seattle,wa, United States, national heart,lung,and blood institute's and boston university's framingham heart study,framingham,ma,united states,section of preventive medicine and epidemiology,department of medicine,boston university school of medicine,boston,ma,united states,department of epidemiology,boston university school of public health,boston,ma, United States, celera,alameda,ca, United States, amgen,cambridge,ma, United States, center for cardiovascular disease prevention,brigham and women's hospital,harvard medical school,boston,ma,united states,donald w. reynolds center for cardiovascular research,brigham and women's hospital,harvard medical school,boston,ma, United States
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