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Adaptations to climate-mediated selective pressures in humans
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نویسنده
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hancock a.m. ,witonsky d.b. ,alkorta-aranburu g. ,beall c.m. ,gebremedhin a. ,sukernik r. ,utermann g. ,pritchard j.k. ,coop g. ,di rienzo a.
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منبع
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plos genetics - 2011 - دوره : 7 - شماره : 4
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چکیده
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Humans inhabit a remarkably diverse range of environments,and adaptation through natural selection has likely played a central role in the capacity to survive and thrive in extreme climates. unlike numerous studies that used only population genetic data to search for evidence of selection,here we scan the human genome for selection signals by identifying the snps with the strongest correlations between allele frequencies and climate across 61 worldwide populations. we find a striking enrichment of genic and nonsynonymous snps relative to non-genic snps among those that are strongly correlated with these climate variables. among the most extreme signals,several overlap with those from gwas,including snps associated with pigmentation and autoimmune diseases. further,we find an enrichment of strong signals in gene sets related to uv radiation,infection and immunity,and cancer. our results imply that adaptations to climate shaped the spatial distribution of variation in humans. © 2011 hancock et al.
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آدرس
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department of human genetics,university of chicago,chicago,il, United States, department of human genetics,university of chicago,chicago,il, United States, department of human genetics,university of chicago,chicago,il, United States, department of anthropology,case western research university,cleveland,oh, United States, department of internal medicine,addis ababa university,addis ababa, Ethiopia, laboratory of human molecular genetics,department of molecular and cellular biology,institute of chemical biology and fundamental medicine,russian academy of sciences,novosibirsk, Russian Federation, institute for medical biology and human genetics,medical university of innsbruck,innsbruck, Austria, department of human genetics,university of chicago,chicago,il,united states,howard hughes medical institute,chevy chase,md, United States, department of human genetics,university of chicago,chicago,il,united states,department of evolution and ecology and center for population biology,university of california davis,davis,ca, United States, department of human genetics,university of chicago,chicago,il, United States
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Authors
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