plos genetics سال:2011 - دوره:7

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plos genetics
سال:2011 - دوره:7 - شماره:10

A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover A conserved developmental patterning network produces quantitatively different output in multiple species of drosophila A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol A one base pair deletion in the canine ATP13A2 gene causes exon skipping and late-onset neuronal ceroid lipofuscinosis in the Tibetan terrier A phenomics-based strategy identifies loci on APOC1,BRAP,and PLCG1 associated with metabolic syndrome phenotype domains A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis An adaptive allelic series featuring complex gene rearrangements Association of NCF2,IKZF1,IRF8,IFIH1,and TYK2 with systemic lupus erythematosus Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis CtIP mutations cause Seckel and Jawad syndromes Developmental stability: A major role for Cyclin G in Drosophila melanogaster Dynamic replacement of histone H3 variants reprograms epigenetic marks in early mouse embryos Feed-forward microprocessing and splicing activities at a microRNA-containing intron Genetic determinants of serum testosterone concentrations in men Genetic diversity in cytokines associated with immune variation and resistance to multiple pathogens in a natural rodent population Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies Genetic rearrangements can modify chromatin features at epialleles Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping Identification of widespread ultra-edited human RNAs Identification,replication,and fine-mapping of loci associated with adult height in individuals of African ancestry Insights into hox protein function from a large scale combinatorial analysis of protein domains Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice MicroRNA expression and regulation in human,chimpanzee,and macaque brains Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells Mutations in a guanylate cyclase GCY-35/GCY-36 modify bardet-biedl syndrome-associated phenotypes in Caenorhabditis elegans Mutator suppression and escape from replication error-induced extinction in yeast Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome Novel function of Distal-less as a gap gene during spider segmentation Oxr1 is essential for protection against oxidative stress-induced neurodegeneration Positional cloning of a type 2 diabetes quantitative trait locus; Tomosyn-2,a negative regulator of insulin secretion Preventing dangerous nonsense: Selection for robustness to transcriptional error in human genes Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia Small RNAs prevent transcription-coupled loss of histone H3 lysine 9 methylation in Arabidopsis thaliana Successive increases in the resistance of Drosophila to viral infection through a transposon insertion followed by a duplication Temporal coordination of gene networks by Zelda in the early Drosophila embryo The Thermoanaerobacter glycobiome reveals mechanisms of pentose and hexose co-utilization in bacteria The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila Transcriptional robustness complements nonsense-mediated decay in humans Transcriptome-wide binding sites for components of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1,Nab3,and Sen1 Transforming growth factor β receptor type 1 is essential for female reproductive tract integrity and function Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: Associations with germline VHL polymorphisms and etiologic risk factors Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spastic ataxia-neuropathy syndrome linked to mitochondrial m-AAA proteases Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition