|
|
|
|
Identification,replication,and fine-mapping of loci associated with adult height in individuals of African ancestry
|
|
|
|
|
|
|
|
نویسنده
|
n'diaye a. ,chen g.k. ,palmer c.d. ,ge b. ,tayo b. ,mathias r.a. ,ding j. ,nalls m.a. ,adeyemo a. ,adoue v. ,ambrosone c.b. ,atwood l. ,bandera e.v. ,becker l.c. ,berndt s.i. ,bernstein l. ,blot w.j. ,boerwinkle e. ,britton a. ,casey g. ,chanock s.j. ,demerath e. ,deming s.l. ,diver w.r. ,fox c. ,harris t.b. ,hernandez d.g. ,hu j.j. ,ingles s.a. ,john e.m. ,johnson c. ,keating b. ,kittles r.a. ,kolonel l.n. ,kritchevsky s.b. ,marchand l. ,lohman k. ,liu j. ,millikan r.c. ,murphy a. ,musani s. ,neslund-dudas c. ,north k.e. ,nyante s. ,ogunniyi a. ,ostrander e.a. ,papanicolaou g. ,patel s. ,pettaway c.a. ,press m.f. ,redline s. ,rodriguez-gil j.l. ,rotimi c. ,rybicki b.a. ,salako b. ,schreiner p.j. ,signorello l.b. ,singleton a.b. ,stanford j.l. ,stram a.h. ,stram d.o. ,strom s.s. ,suktitipat b. ,thun m.j. ,witte j.s. ,yanek l.r. ,ziegler r.g. ,zheng w. ,zhu x. ,zmuda j.m. ,zonderman a.b. ,evans m.k. ,liu y. ,becker d.m. ,cooper r.s. ,pastinen t. ,henderson b.e. ,hirschhorn j.n. ,lettre g. ,haiman c.a.
|
|
منبع
|
plos genetics - 2011 - دوره : 7 - شماره : 10
|
|
چکیده
|
Adult height is a classic polygenic trait of high heritability (h 2 ~0.8). more than 180 single nucleotide polymorphisms (snps),identified mostly in populations of european descent,are associated with height. these variants convey modest effects and explain ~10% of the variance in height. discovery efforts in other populations,while limited,have revealed loci for height not previously implicated in individuals of european ancestry. here,we performed a meta-analysis of genome-wide association (gwa) results for adult height in 20,427 individuals of african ancestry with replication in up to 16,436 african americans. we found two novel height loci (xp22-rs12393627,p = 3.4×10 -12 and 2p14-rs4315565,p = 1.2×10 -8). as a group,height associations discovered in european-ancestry samples replicate in individuals of african ancestry (p = 1.7×10 -4 for overall replication). fine-mapping of the european height loci in african-ancestry individuals showed an enrichment of snps that are associated with expression of nearby genes when compared to the index european height snps (p<0.01). our results highlight the utility of genetic studies in non-european populations to understand the etiology of complex human diseases and traits. © 2011 n'diaye et al.
|
|
|
|
|
آدرس
|
montreal heart institute,montréal, Canada, department of preventive medicine,keck school of medicine and norris comprehensive cancer center,university of southern california,los angeles,ca, United States, program in medical and population genetics,broad institute,cambridge,ma,united states,divisions of genetics and endocrinology and program in genomics,children's hospital boston,boston,ma, United States, department of human genetics,mcgill university,genome quebec innovation centre,montreal, Canada, department of preventive medicine and epidemiology,loyola university chicago stritch school of medicine,maywood,il, United States, department of medicine,the johns hopkins genestar research program,the johns hopkins university school of medicine,baltimore,md, United States, sticht center on aging,wake forest university school of medicine,winston-salem,nc, United States, laboratory of neurogenetics,national institute on aging,national institutes of health,bethesda,md, United States, nih intramural center for research on genomics and global health,national human genome research institute,national institutes of health,bethesda,md, United States, department of human genetics,mcgill university,genome quebec innovation centre,montreal, Canada, department of cancer prevention and control,roswell park cancer institute,buffalo,ny, United States, department of neurology,boston university school of medicine,boston,ma, United States, the cancer institute of new jersey,new brunswick,nj, United States, department of medicine,the johns hopkins genestar research program,the johns hopkins university school of medicine,baltimore,md, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, division of cancer etiology,department of population science,beckman research institute,city of hope,duarte,ca, United States, international epidemiology institute,rockville,md,united states,division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt university,nashville,tn,united states,vanderbilt-ingram cancer center,nashville,tn, United States, human genetics center,institute of molecular medicine and division of epidemiology,university of texas health science center,houston,tx, United States, laboratory of neurogenetics,national institute on aging,national institutes of health,bethesda,md, United States, department of preventive medicine,keck school of medicine and norris comprehensive cancer center,university of southern california,los angeles,ca, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, division of epidemiology and community health,university of minnesota school of public health,minneapolis,mn, United States, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt university,nashville,tn,united states,vanderbilt-ingram cancer center,nashville,tn, United States, epidemiology research program,american cancer society,atlanta,ga, United States, department of medicine,university of mississippi medical center,jackson,ms, United States, laboratory of epidemiology,demography,and biometry,national institute on aging,national institutes of health,bethesda,md, United States, laboratory of neurogenetics,national institute on aging,national institutes of health,bethesda,md, United States, sylvester comprehensive cancer center,department of epidemiology and public health,university of miami miller school of medicine,miami,fl, United States, department of preventive medicine,keck school of medicine and norris comprehensive cancer center,university of southern california,los angeles,ca, United States, cancer prevention institute of california,fremont,ca,united states,school of medicine and stanford cancer center,stanford university,stanford,ca, United States, department of biostatistics,university of washington,seattle,wa, United States, center for applied genomics,children's hospital of philadelphia,philadelphia,pa, United States, department of medicine,university of illinois at chicago,chicago,il, United States, epidemiology program,cancer research center,university of hawaii,honolulu,hi, United States, sticht center on aging,wake forest university school of medicine,winston-salem,nc, United States, epidemiology program,cancer research center,university of hawaii,honolulu,hi, United States, sticht center on aging,wake forest university school of medicine,winston-salem,nc, United States, university of mississippi medical center,jackson,ms, United States, department of epidemiology,gillings school of global public health and lineberger comprehensive cancer center,university of north carolina,chapel hill,nc, United States, department of urology,northwestern university,chicago,il, United States, jackson heart study,department of medicine,division of cardiovascular disease,university of mississippi medical center,jackson,ms, United States, department of biostatistics and research epidemiology,henry ford hospital,detroit,mi, United States, department of epidemiology,university of north carolina,chapel hill,nc,united states,carolina center for genome sciences,university of north carolina,chapel hill,nc, United States, department of epidemiology,gillings school of global public health and lineberger comprehensive cancer center,university of north carolina,chapel hill,nc, United States, department of medicine,university of ibadan,ibadan, Nigeria, cancer genetics branch,national human genome research institute,national institutes of health,bethesda,md, United States, national heart,lung,and blood institute (nhlbi),division of cardiovascular sciences,national institutes of health,bethesda,md, United States, division of sleep medicine,brigham and women's hospital,boston,ma, United States, department of urology,the university of texas m. d. anderson cancer center,houston,tx, United States, department of pathology,keck school of medicine and norris comprehensive cancer center,university of southern california,los angeles,ca, United States, division of sleep medicine,brigham and women's hospital,boston,ma, United States, sylvester comprehensive cancer center,department of epidemiology and public health,university of miami miller school of medicine,miami,fl, United States, nih intramural center for research on genomics and global health,national human genome research institute,national institutes of health,bethesda,md, United States, department of biostatistics and research epidemiology,henry ford hospital,detroit,mi, United States, department of medicine,university of ibadan,ibadan, Nigeria, division of epidemiology and community health,university of minnesota,minneapolis,mn, United States, international epidemiology institute,rockville,md,united states,division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt university,nashville,tn,united states,vanderbilt-ingram cancer center,nashville,tn, United States, laboratory of neurogenetics,national institute on aging,national institutes of health,bethesda,md, United States, division of public health sciences,fred hutchinson cancer research center,seattle,wa, United States, department of preventive medicine,keck school of medicine and norris comprehensive cancer center,university of southern california,los angeles,ca, United States, department of preventive medicine,keck school of medicine and norris comprehensive cancer center,university of southern california,los angeles,ca, United States, department of epidemiology,the university of texas m. d. anderson cancer center,houston,tx, United States, department of medicine,the johns hopkins genestar research program,the johns hopkins university school of medicine,baltimore,md,united states,the johns hopkins bloomberg school of public health,baltimore,md, United States, epidemiology research program,american cancer society,atlanta,ga, United States, institute for human genetics,departments of epidemiology and biostatistics and urology,university of california san francisco,san francisco,ca, United States, department of medicine,the johns hopkins genestar research program,the johns hopkins university school of medicine,baltimore,md, United States, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,bethesda,md, United States, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt university,nashville,tn,united states,vanderbilt-ingram cancer center,nashville,tn, United States, department of biostatistics and epidemiology,case western reserve university,cleveland,oh, United States, department of epidemiology,graduate school of public health,university of pittsburgh,pittsburgh,pa, United States, laboratory of personality and cognition,national institute on aging,national institutes of health,baltimore,md, United States, health disparities research section,clinical research branch,national institute on aging,national institutes of health,baltimore,md, United States, sticht center on aging,wake forest university school of medicine,winston-salem,nc, United States, department of medicine,the johns hopkins genestar research program,the johns hopkins university school of medicine,baltimore,md, United States, department of preventive medicine and epidemiology,loyola university chicago stritch school of medicine,maywood,il, United States, department of human genetics,mcgill university,genome quebec innovation centre,montreal, Canada, department of preventive medicine,keck school of medicine and norris comprehensive cancer center,university of southern california,los angeles,ca, United States, program in medical and population genetics,broad institute,cambridge,ma,united states,divisions of genetics and endocrinology and program in genomics,children's hospital boston,boston,ma,united states,department of medicine,harvard medical school,boston,ma, United States, montreal heart institute,montréal,canada,département de médecine,université de montréal,montréal, Canada, department of preventive medicine,keck school of medicine and norris comprehensive cancer center,university of southern california,los angeles,ca, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|