journal of experimental and clinical cancer research سال:2017 - دوره:36

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journal of experimental and clinical cancer research
سال:2017 - دوره:36 - شماره:1

(S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1 5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer ALX4,an epigenetically down regulated tumor suppressor,inhibits breast cancer progression by interfering Wnt/β-catenin pathway ANGPTL1 attenuates colorectal cancer metastasis by up-regulating microRNA-138 Aberrant activation of hedgehog signaling promotes cell proliferation via the transcriptional activation of forkhead Box M1 in colorectal cancer cells - صفحه:1-11 Adipocytes promote cholangiocarcinoma metastasis through fatty acid binding protein 4 Akt/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma Alantolactone,a natural sesquiterpene lactone,has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades Angiotensin II type 2 receptor promotes apoptosis and inhibits angiogenesis in bladder cancer Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma Antibody targeting of claudin-1 as a potential colorectal cancer therapy Apigenin,by activating p53 and inhibiting STAT3,modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death Autophagy maintains the stemness of ovarian cancer stem cells by FOXA2. Benserazide,a dopadecarboxylase inhibitor,suppresses tumor growth by targeting hexokinase 2 Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma Breast carcinomas with low amplified/equivocal HER2 by Ish: Potential supporting role of multiplex ligation-dependent probe amplification Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling CIP2A mediates fibronectin-induced bladder cancer cell proliferation by stabilizing β-catenin CLDN6 promotes chemoresistance through GSTP1 in human breast cancer CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling Can recurrences be predicted in craniopharyngiomas? β-catenin coexisting with stem cells markers and p-ATM in a clinicopathologic study of 45cases Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway - صفحه:1-13 Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine - صفحه:1-12 Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2 Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6 CircGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a Circular RNAs: Emerging cancer biomarkers and targets Cisplatin triggers cancer stem cell enrichment in platinum-resistant cells through NF-κB-TNFα-PIK3CA loop Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis Combined targeting of Arf1 and Ras potentiates anticancer activity for prostate cancer therapeutics Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells Correction to: Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling (Journal of Experimental and Clinical Cancer Research (2017) 36:1 (153) DOI: 10.1186/s13046-017-0625-y) Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics - صفحه:1-14 Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy,AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice Curcumin: The spicy modulator of breast carcinogenesis Current concepts in bone metastasis,contemporary therapeutic strategies and ongoing clinical trials Deptor: Not only a mTOR inhibitor Diagnosis and treatment of ALT tumors: Is Trabectedin a new therapeutic option? Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer Direct inhibition of ACTN4 by ellagic acid limits breast cancer metastasis via regulation of β-catenin stabilization in cancer stem cells Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - Synergism with autophagy inhibition Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells Disulfiram overcomes bortezomib and cytarabine resistance in Down-syndrome-associated acute myeloid leukemia cells - صفحه:1-14 Downregulation of long noncoding RNA MEG3 is associated with poor prognosis and promoter hypermethylation in cervical cancer Downregulation of miR-141-3p promotes bone metastasis via activating NF-κB signaling in prostate cancer Downregulation of miR-31 stimulates expression of LATS2 via the hippo pathway and promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma Doxorubicin combined with low intensity ultrasound suppresses the growth of oral squamous cell carcinoma in culture and in xenografts Drug repurposing for the treatment of glioblastoma multiforme E2F8,a direct target of miR-144,promotes papillary thyroid cancer progression via regulating cell cycle ERβ1 inhibits metastasis of androgen receptor-positive triple-negative breast cancer by suppressing ZEB1 Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and tumorigenicity in nasopharyngeal carcinoma by inhibiting cell cycle arrest Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1) Epithelial-to-mesenchymal transition in FHC-silenced cells: The role of CXCR4/CXCL12 axis Erratum to: CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling (J Exp Clin Cancer Res (2017) 36 (21) DOI: 10.1186/s13046-016-0483-z) - صفحه:1- Erratum to: Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node,intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase (J Exp Clin Cancer Res (2016) 35:1 (193) DOI: 10.1186/s13046-016-0460-6) Erratum to: RERG suppresses cell proliferation,migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma (Journal of Experimental and Clinical Cancer Research (2017) 36:1 (88) DOI: 10.1186/s13046-017-0554-9) Erratum to: The role of the AMOP domain in MUC4/Y-promoted tumour angiogenesis and metastasis in pancreatic cancer (Journal of Experimental and Clinical Cancer Research (2016) 35:91 DOI: 10.1186/s13046-016-0369-0) Erratum: A panel of four genes accurately differentiates benign from malignant thyroid nodules (Journal of Experimental and Clinical Cancer Research (2016) 35 (169) DOI: 10.1186/s13046-016-0447-3) Erratum: Pathologically decreased expression of miR-193a contributes to metastasis by targeting WT1-E-cadherin axis in non-small cell lung cancers(J Exp Clin Cancer Res. (2016)35 (173) DOI:10.1186/s13046-016-0450-8) Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells Exosomes isolated from cancer patients' sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells FOXA1 inhibits hepatocellular carcinoma progression by suppressing PIK3R1 expression in male patients FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2) - صفحه:107- Genotypes of SLC22A4 and SLC22A5 regulatory loci are predictive of the response of chronic myeloid leukemia patients to imatinib treatment HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features HIF-1α promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment HOXB7 accelerates the malignant progression of hepatocellular carcinoma by promoting stemness and epithelial-mesenchymal transition Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation High expression of Bruton's tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods HrHPV E5 oncoprotein: Immune evasion and related immunotherapies Human breast adipose tissue: characterization of factors that change during tumor progression in human breast cancer - صفحه:1-13 Human mesenchymal stromal cells as cellular drug-delivery vectors for glioblastoma therapy: A good deal? Hypermethylation and loss of retinoic acid receptor responder 1 expression in human choriocarcinoma ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population ID1 promotes hepatocellular carcinoma proliferation and confers chemoresistance to oxaliplatin by activating pentose phosphate pathway IL-27 mediates HLA class i up-regulation,which can be inhibited by the IL-6 pathway,in HLA-deficient Small Cell Lung Cancer cells Ibrutinib,a Bruton's tyrosine kinase inhibitor,exhibits antitumoral activity and induces autophagy in glioblastoma Identification and validation of a 44-gene expression signature for the classification of renal cell carcinomas In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation Inhibition of EGR1 inhibits glioma proliferation by targeting CCND1 promoter Inhibition of autophagy enhances the selective anti-cancer activity of tigecycline to overcome drug resistance in the treatment of chronic myeloid leukemia Intake of Boron,Cadmium,and Molybdenum enhances rat thyroid cell transformation Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell Intracellular pH-responsive and rituximab-conjugated mesoporous silica nanoparticles for targeted drug delivery to lymphoma B cells - صفحه:1-14 Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells Kindlin-2 promotes hepatocellular carcinoma invasion and metastasis by increasing Wnt/β-catenin signaling LPS alters the immuno-phenotype of glioma and glioma stem-like cells and induces in vivo antitumor immunity via TLR4 Linc-ROR promotes esophageal squamous cell carcinoma progression through the derepression of SOX9 Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer Liquid dynamic medicine and N-of-1 clinical trials: A change of perspective in oncology research LncRNA AK023391 promotes tumorigenesis and invasion of gastric cancer through activation of the PI3K/Akt signaling pathway Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-κB/Snail pathway Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes tumorigenesis and metastasis by targeting miR-199a/b-5p in hepatocellular carcinoma Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma MIF/CD74 axis is a target for novel therapies in colon carcinomatosis - صفحه:1-15 Maintenance of stemness is associated with the interation of LRP6 and heparin-binding protein CCN2 autocrined by hepatocellular carcinoma MiR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: Validation by bioinformatics and experimental analyses MiR-203a-3p suppresses cell proliferation and metastasis through inhibiting LASP1 in nasopharyngeal carcinoma MiR-361-5p inhibits glycolytic metabolism,proliferation and invasion of breast cancer by targeting FGFR1 and MMP-1 MiR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells MicroRNA-27a contributes to the malignant behavior of gastric cancer cells by directly targeting PH domain and leucine-rich repeat protein phosphatase 2 MicroRNA-381 inhibits the metastasis of gastric cancer by targeting TMEM16A expression Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness Musashi-2,a novel oncoprotein promoting cervical cancer cell growth and invasion,is negatively regulated by p53-induced miR-143 and miR-107 activation NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma Nomogram integrating gene expression signatures with clinicopathological features to predict survival in operable NSCLC: A pooled analysis of 2164 patients Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma Novel glycolipid agents for killing cisplatin-resistant human epithelial ovarian cancer cells Nucleolar and spindle associated protein 1 promotes the aggressiveness of astrocytoma by activating the Hedgehog signaling pathway Oleuropein enhances radiation sensitivity of nasopharyngeal carcinoma by downregulating PDRG1 through HIF1α-repressed microRNA-519d Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer P53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo PDGFA/PDGFRα-regulated GOLM1 promotes human glioma progression through activation of AKT PDL1 and LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a PEG10 overexpression induced by E2F-1 promotes cell proliferation,migration,and invasion in pancreatic cancer PHF21B overexpression promotes cancer stem cell-like traits in prostate cancer cells by activating the Wnt/β-catenin signaling pathway PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer - صفحه:179- PTEN expression is upregulated by a RNA-binding protein RBM38 via enhancing its mRNA stability in breast cancer Patient-derived xenograft in zebrafish embryos: A new platform for translational research in gastric cancer Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition - صفحه:79- Predictive biomarkers for the efficacy of peptide vaccine treatment: based on the results of a phase II study on advanced pancreatic cancer - صفحه:36- Pro-inflammation NF-κB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells Prognostic stratification improvement by integrating ID1/ID3/IGJ gene expression signature and immunophenotypic profile in adult patients with B-ALL RERG suppresses cell proliferation,migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer - صفحه:1-11 Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells Regulation of TRIM24 by miR-511 modulates cell proliferation in gastric cancer - صفحه:1-11 Regulation of human glioma cell apoptosis and invasion by miR-152-3p through targeting DNMT1 and regulating NF2: MiR-152-3p regulate glioma cell apoptosis and invasion Regulation of submaxillary gland androgen-regulated protein 3A via estrogen receptor 2 in radioresistant head and neck squamous cell carcinoma cells - صفحه:1-9 Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer Retraction Note: MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling (Journal of Experimental and Clinical Cancer Research (2016) 35 (47) DOI: 10.1186/s13046-016-0323-1) SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC Sex-determining region Y-box protein 3 induces epithelial-mesenchymal transition in osteosarcoma cells via transcriptional activation of Snail1 - صفحه:46- Short course hypofractionated whole breast irradiation after conservative surgery: A single institution phase II study Short-term early exposure to lapatinib confers lifelong protection from mammary tumor development in MMTV-ERBB-2 transgenic mice Silencing of miR-193a-5p increases the chemosensitivity of prostate cancer cells to docetaxel - صفحه:178- Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations Smoldering mantle cell lymphoma Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells Stathmin is overexpressed and regulated by mutant p53 in oral squamous cell carcinoma Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells Synergistic antitumor interaction between valproic acid,capecitabine and radiotherapy in colorectal cancer: Critical role of p53 Synthetic regulatory RNAs selectively suppress the progression of bladder cancer TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells' invasion Targeting the cross-talk between Urokinase receptor and Formyl peptide receptor type 1 to prevent invasion and trans-endothelial migration of melanoma cells Ternary cocktail nanoparticles for sequential chemo-photodynamic therapy The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer The acid-sensing ion channel,ASIC2,promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells The changing face of clinical trials in the personalized medicine and immuno-oncology era: Report from the international congress on clinical trials in Oncology & Hemato-Oncology (ICTO 2017) The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation The oncogenic Golgi phosphoprotein 3 like overexpression is associated with cisplatin resistance in ovarian carcinoma and activating the NF-κB signaling pathway The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma The role of c-Myc-RBM38 loop in the growth suppression in breast cancer The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines Trastuzumab emtansine delays and overcomes resistance to the third-generation EGFR-TKI osimertinib in NSCLC EGFR mutated cell lines Trifluoperazine,a novel autophagy inhibitor,increases radiosensitivity in glioblastoma by impairing homologous recombination Type II CRISPR/Cas9 approach in the oncological therapy Up-regulation of CDK16 by multiple mechanisms in hepatocellular carcinoma promotes tumor progression Upregulation of DARS2 by HBV promotes hepatocarcinogenesis through the miR-30e-5p/MAPK/NFAT5 pathway Vitamin D receptor,Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4),a dual YAP/COX-2 inhibitor,overcomes drug resistance in colorectal cancer iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling β-catenin-mediated YAP signaling promotes human glioma growth