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Liquid dynamic medicine and N-of-1 clinical trials: A change of perspective in oncology research
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نویسنده
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silvestris n. ,ciliberto g. ,de paoli p. ,apolone g. ,lavitrano m.l. ,pierotti m.a. ,stanta g.
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منبع
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journal of experimental and clinical cancer research - 2017 - دوره : 36 - شماره : 1
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چکیده
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The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients,and the growing application of liquid biopsy to dynamically track tumor evolution and to adapt molecularly targeted therapy according to the emergence of tumor clonal variants is shaping modern medical oncology.,in order to better describe this new therapeutic paradigm we propose the term liquid dynamic medicine in the place of personalized or precision medicine. clinical validation of the liquid dynamic medicine approach is best captured by n-of-1 trials where each patient acts as tester and control of truly personalized therapies. © 2017 the author(s).
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کلیدواژه
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Clinical trials; Dynamic; Fluid; N-of-1 trials; Personalized medicine; Target therapy
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آدرس
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medical oncology unit and scientific dir.,cancer institute giovanni paolo ii,viale orazio flacco,65,bari,70124, Italy, scientific dir.,irccs national cancer institute regina elena,rome, Italy, scientific dir.,irccs centro di riferimento oncologico,aviano, Italy, scientific dir.,fondazione irccs istituto nazionale dei tumori,milan, Italy, bbmri.it,department of medicine and surgery,university milano-bicocca,milan, Italy, senior group leader foundation,institute firc molecular oncology (ifom) milan,milan, Italy, department of medical sciences,university of trieste,trieste, Italy
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Authors
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