plos genetics سال:2011 - دوره:7

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plos genetics
سال:2011 - دوره:7 - شماره:3

A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans A cholinergic-regulated circuit coordinates the maintenance and bi-stable states of a sensory-motor behavior during Caenorhabditis elegans male copulation A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium A molecular phylogeny of living primates A novel unstable duplication upstream of HAS2 predisposes to a breed-defining skin phenotype and a periodic fever syndrome in Chinese Shar-Pei dogs A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line A tradeoff drives the evolution of reduced metal resistance in natural populations of yeast ARGONAUTE10 and ARGONAUTE1 regulate the termination of floral stem cells through two microRNAs in Arabidopsis Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis Arabidopsis COMPASS-like complexes mediate histone H3 lysine-4 trimethylation to control floral transition and plant development Cancer-associated splicing variant of tumor suppressor AIMP2/p38: Pathological implication in tumorigenesis Chiasmata promote monopolar attachment of sister chromatids and their co-segregation toward the proper pole during meiosis I Cyclin E and Cdk2 control GLD-1,the mitosis/meiosis decision,and germline stem cells in Caenorhabditis elegans Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production Diverse roles and interactions of the SWI/SNF chromatin remodeling complex revealed using global approaches Dopamine signalling in mushroom bodies regulates temperature-preference behaviour in Drosophila Environmental sex determination in the branchiopod crustacean Daphnia magna: Deep conservation of a Doublesex gene in the sex-determining pathway Estimating divergence time and ancestral effective population size of Bornean and Sumatran orangutan subspecies using a coalescent hidden Markov model Expanded CAG/CTG repeat DNA induces a checkpoint response that impacts cell proliferation in Saccharomyces cerevisiae FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration Genetic regulation by NLA and microRNA827 for maintaining nitrate-dependent phosphate homeostasis in Arabidopsis Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits Genome-wide interaction-based association analysis identified multiple new susceptibility loci for common diseases Global analysis of the relationship between JIL-1 kinase and transcription Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans Identification of a novel type of spacer element required for imprinting in fission yeast Initial mutations direct alternative pathways of protein evolution Interactions among polycomb domains are guided by chromosome architecture Limited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) Macoilin,a conserved nervous system-specific ER membrane protein that regulates neuronal excitability Origin-dependent inverted-repeat amplification: A replication-based model for generating palindromic amplicons Phenotype restricted genome-wide association study using a gene-centric approach identifies three low-risk neuroblastoma susceptibility loci Polycomb repressive complex 2 controls the embryo-to-seedling phase transition Polycomb targets seek closest neighbours Population-based resequencing of experimentally evolved populations reveals the genetic basis of body size variation in Drosophila melanogaster Quantifying the underestimation of relative risks from genome-wide association studies REVEILLE8 and PSEUDO-REPONSE REGULATOR5 form a negative feedback loop within the arabidopsis circadian clock Repeat associated non-ATG translation initiation: One DNA,two transcripts,seven reading frames,potentially nine toxic entities! Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae Rif1 supports the function of the CST complex in yeast telomere capping Role of the drosophila non-visual ß-arrestin kurtz in hedgehog signalling Roles of brca2 (fancd1) in oocyte nuclear architecture,gametogenesis,gonad tumors,and genome stability in zebrafish Roles of the espin actin-bundling proteins in the morphogenesis and stabilization of hair cell stereocilia revealed in CBA/CaJ congenic jerker mice SUMO-targeted ubiquitin ligase,Rad60,and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε Systematic detection of polygenic cis-regulatory evolution Testing for an unusual distribution of rare variants The FUN30 chromatin remodeler,Fft3,protects centromeric and subtelomeric domains from euchromatin formation The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress The SUVR4 histone lysine methyltransferase binds ubiquitin and converts H3K9me1 to H3K9me3 on transposon chromatin in arabidopsis The recombinases Rad51 and Dmc1 play distinct roles in DNA break repair and recombination partner choice in the meiosis of Tetrahymena The toll-like receptor gene family is integrated into human DNA damage and p53 networks Triplet repeat-derived siRNAs enhance RNA-mediated toxicity in a drosophila model for myotonic dystrophy Ultra-deep sequencing of mouse mitochondrial DNA: Mutational patterns and their origins Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster Viral genome segmentation can result from a trade-off between genetic content and particle stability Whole-exome re-sequencing in a family quartet identifies POP1 mutations as the cause of a novel skeletal dysplasia Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis c-di-GMP turn-over in Clostridium difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterases