A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium

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A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium


نویسنده	mckay j.d. ,truong t. ,gaborieau v. ,chabrier a. ,chuang s.-c. ,byrnes g. ,zaridze d. ,shangina o. ,szeszenia-dabrowska n. ,lissowska j. ,rudnai p. ,fabianova e. ,bucur a. ,bencko v. ,holcatova i. ,janout v. ,foretova l. ,lagiou p. ,trichopoulos d. ,benhamou s. ,bouchardy c. ,ahrens w. ,merletti f. ,richiardi l. ,talamini r. ,barzan l. ,kjaerheim k. ,macfarlane g.j. ,macfarlane t.v. ,simonato l. ,canova c. ,agudo a. ,castellsagué x. ,lowry r. ,conway d.i. ,mckinney p.a. ,healy c.m. ,toner m.e. ,znaor a. ,curado m.p. ,koifman s. ,menezes a. ,wünsch-filho v. ,neto j.e. ,garrote l.f. ,boccia s. ,cadoni g. ,arzani d. ,olshan a.f. ,weissler m.c. ,funkhouser w.k. ,luo j. ,lubiński j. ,trubicka j. ,lener m. ,oszutowska d. ,schwartz s.m. ,chen c. ,fish s. ,doody d.r. ,muscat j.e. ,lazarus p. ,gallagher c.j. ,chang s.-c. ,zhang z.-f. ,wei q. ,sturgis e.m. ,wang l.-e. ,franceschi s. ,herrero r. ,kelsey k.t. ,mcclean m.d. ,marsit c.j. ,nelson h.h. ,romkes m. ,buch s. ,nukui t. ,zhong s. ,lacko m. ,manni j.j. ,peters w.h.m. ,hung r.j. ,mclaughlin j. ,vatten l. ,njølstad i. ,goodman g.e. ,field j.k. ,liloglou t. ,vineis p. ,clavel-chapelon f. ,palli d. ,tumino r. ,krogh v. ,panico s. ,gonzález c.a. ,quirós j.r. ,martínez c. ,navarro c. ,ardanaz e. ,larrañaga n. ,khaw k.-t. ,key t. ,bueno-de-mesquita h.b. ,peeters p.h.m. ,trichopoulou a. ,linseisen j. ,boeing h. ,hallmans g. ,overvad k. ,tjønneland a. ,kumle m. ,riboli e. ,välk k. ,voodern t. ,metspalu a. ,zelenika d. ,boland a. ,delepine m. ,foglio m. ,lechner d. ,blanché h. ,gut i.g. ,galan p. ,heath s. ,hashibe m. ,hayes r.b. ,boffetta p. ,lathrop m. ,brennan p.
منبع	plos genetics - 2011 - دوره : 7 - شماره : 3
چکیده	Genome-wide association studies (gwas) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. we conducted a gwas to identify common genetic variation involved in susceptibility to upper aero-digestive tract (uadt) cancers. genome-wide genotyping was carried out using the illumina humanhap300 beadchips in 2,091 uadt cancer cases and 3,513 controls from two large european multi-centre uadt cancer studies,as well as 4,821 generic controls. the 19 top-ranked variants were investigated further in an additional 6,514 uadt cancer cases and 7,892 controls of european descent from an additional 13 uadt cancer studies participating in the inhance consortium. five common variants presented evidence for significant association in the combined analysis (p≤5×10-7). two novel variants were identified,a 4q21 variant (rs1494961,p = 1×10-8) located near dna repair related genes hel308 and fam175a (or abraxas) and a 12q24 variant (rs4767364,p = 2×10-8) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (aldh2) gene. three remaining variants are located in the adh gene cluster and were identified previously in a candidate gene study involving some of these samples. the association between these three variants and uadt cancers was independently replicated in 5,092 uadt cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-adh7,p = 5×10-8; rs1229984-adh1b,p = 7×10-9; and rs698-adh1c,p = 0.02). these results implicate two variants at 4q21 and 12q24 and further highlight three adh variants in uadt cancer susceptibility. © 2011 mckay et al.

آدرس	international agency for research on cancer (iarc),lyon, France, international agency for research on cancer (iarc),lyon, France, international agency for research on cancer (iarc),lyon, France, international agency for research on cancer (iarc),lyon, France, international agency for research on cancer (iarc),lyon, France, international agency for research on cancer (iarc),lyon, France, institute of carcinogenesis,cancer research centre,moscow, Russian Federation, institute of carcinogenesis,cancer research centre,moscow, Russian Federation, department of epidemiology,institute of occupational medicine,lodz, Poland, the m. sklodowska-curie memorial cancer center and institute of oncology,warsaw, Poland, national institute of environmental health,budapest, Hungary, regional authority of public health,banská bystrica, Slovakia, institute of public health,bucharest, Romania, institute of hygiene and epidemiology,1st faculty of medicine,charles university,prague, Czech Republic, institute of hygiene and epidemiology,1st faculty of medicine,charles university,prague, Czech Republic, palacky university,olomouc, Czech Republic, department of cancer epidemiology and genetics,masaryk memorial cancer institute,brno, Czech Republic, department of hygiene,epidemiology,and medical statistics,university of athens school of medicine,athens, Greece, department of hygiene,epidemiology,and medical statistics,university of athens school of medicine,athens,greece,department of epidemiology,harvard school of public health,boston,ma, United States, inserm u946,paris,france,cnrs umr8200,gustave roussy institute,villejuif, France, geneva cancer registry,institute for social and preventive medicine,university of geneva,geneva, Switzerland, bremen institute for prevention research and social medicine (bips),university of bremen,bremen, Germany, unit of cancer epidemiology,university of turin,turin, Italy, unit of cancer epidemiology,university of turin,turin, Italy, national cancer institute,ircss,aviano, Italy, general hospital of pordenone,pordenone, Italy, cancer registry of norway,oslo, Norway, school of medicine and dentistry,university of aberdeen,aberdeen, United Kingdom, school of medicine and dentistry,university of aberdeen,aberdeen, United Kingdom, department of environmental medicine and public health,university of padova,padova, Italy, department of environmental medicine and public health,university of padova,padova,italy,respiratory epidemiology and public health,national heart and lung institute,imperial college,london, United Kingdom, institut català d'oncologia (ico),barcelona, Spain, institut català d'oncologia (ico),barcelona,spain,ciber epidemiologia y salud publica (ciberesp),madrid, Spain, university of newcastle dental school,newcastle, United Kingdom, university of glasgow dental school,glasgow, United Kingdom, university of leeds centre for epidemiology and biostatistics,leeds,united kingdom,nhs nss isd,edinburgh, United Kingdom, trinity college school of dental science,dublin, Ireland, trinity college school of dental science,dublin, Ireland, croatian national cancer registry,croatian national institute of public health,zagreb, Croatia, international agency for research on cancer (iarc),lyon, France, national school of public health/fiocruz,rio de janeiro, Brazil, universidade federal de pelotas,pelotas, Brazil, universidade de sao paulo,sao paulo, Brazil, universidade de sao paulo,sao paulo, Brazil, institute of oncology and radiobiology,havana, Cuba, institute of hygiene,università cattolica del sacro cuore,rome,italy,irccs san raffaele pisana,rome, Italy, institute of hygiene,università cattolica del sacro cuore,rome, Italy, institute of hygiene,università cattolica del sacro cuore,rome, Italy, gillings school of global public health,university of north carolina,chapel hill,nc, United States, school of medicine,university of north carolina,chapel hill,nc, United States, school of medicine,university of north carolina,chapel hill,nc, United States, school of medicine,university of north carolina,chapel hill,nc, United States, department of genetics and pathomorphology,international hereditary cancer center,pomeranian medical university,szczecin, Poland, department of genetics and pathomorphology,international hereditary cancer center,pomeranian medical university,szczecin, Poland, department of genetics and pathomorphology,international hereditary cancer center,pomeranian medical university,szczecin, Poland, department of genetics and pathomorphology,international hereditary cancer center,pomeranian medical university,szczecin,poland,department of hygiene,epidemiology,and public health,pomeranian medical university,szczecin, Poland, fred hutchinson cancer research centre,seattle,wa, United States, fred hutchinson cancer research centre,seattle,wa, United States, fred hutchinson cancer research centre,seattle,wa, United States, fred hutchinson cancer research centre,seattle,wa, United States, penn state college of medicine,hershey,pa, United States, penn state college of medicine,hershey,pa, United States, penn state college of medicine,hershey,pa, United States, university of california los angeles school of public health,los angeles,ca, United States, university of california los angeles school of public health,los angeles,ca, United States, university of texas m. d. anderson cancer center,houston,tx, United States, university of texas m. d. anderson cancer center,houston,tx, United States, university of texas m. d. anderson cancer center,houston,tx, United States, international agency for research on cancer (iarc),lyon, France, instituto de investigación epidemiológica,san josé, Costa Rica, brown university,providence,ri, United States, boston university school of public health,boston,ma, United States, brown university,providence,ri, United States, masonic cancer center,university of minnesota,minneapolis,mn, United States, university of pittsburgh,pittsburgh,pa, United States, university of pittsburgh,pittsburgh,pa, United States, university of pittsburgh,pittsburgh,pa, United States, university of pittsburgh,pittsburgh,pa, United States, department of otorhinolaryngology and head and neck surgery,maastricht university medical centre,maastricht, Netherlands, department of otorhinolaryngology and head and neck surgery,maastricht university medical centre,maastricht, Netherlands, department of gastroenterology,st. radboud university nijmegen medical center,nijmegen, Netherlands, samuel lunenfeld research institute of the mount sinai hospital,toronto, Canada, cancer care ontario,toronto, Canada, norwegian university of science and technology,trondheim, Norway, department of community medicine,faculty of health sciences,university of tromso,tromso, Norway, fred hutchinson cancer research centre,seattle,wa, United States, roy castle lung cancer research programme,the university of liverpool cancer research centre,liverpool, United Kingdom, roy castle lung cancer research programme,the university of liverpool cancer research centre,liverpool, United Kingdom, servizio di epidemiologia dei tumori,università di torino and cpo-piemonte,turin,italy,department of epidemiology and public health,imperial college,london, United Kingdom, inserm,e3n-epic group institut gustave roussy,villejuif, France, molecular and nutritional epidemiology unit,cancer research and prevention institute (ispo),florence, Italy, cancer registry and histopathology unit,azienda ospedaliera civile m.p.arezzo,ragusa, Italy, fondazione irccs,istituto nazionale dei tumori,milan, Italy, dipartimento di medicina clinica e sperimentale,universita di napoli federico ii,naples, Italy, unit of nutrition,environment,and cancer (idibell,reticc dr06-0020,catalan institute of oncology (ico),barcelona, Spain, jefe sección información sanitaria,consejería de servicios sociales,principado de asturias,oviedo, Spain, escuela andaluza de salud pública,granada, Spain, ciber epidemiologia y salud publica (ciberesp),madrid,spain,epidemiology department,murcia health council,murcia, Spain, ciber epidemiologia y salud publica (ciberesp),madrid,spain,navarra public health institute,pamplona, Spain, subdirección de salud pública de gipuzkoa,gobierno vasco,san sebastian, Spain, school of clinical medicine,university of cambridge,cambridge, United Kingdom, cancer research uk,university of oxford,oxford, United Kingdom, national institute of public health and the environment (rivm),bilthoven, Netherlands, julius center for health sciences and primary care,department of epidemiology,university medical center of utrecht,utrecht, Netherlands, who collaborating center for nutrition,department of hygiene,epidemiology,and medical statistics,university of athens school of medicine,athens, Greece, institute of epidemiology,helmholtz centre munich,neuherberg,germany,division of clinical epidemiology,german cancer research centre,heidelberg, Germany, department of epidemiology,deutsches institut für ernährungsforschung,potsdam-rehbrücke, Germany, department of public health and clinical medicine,university of umeå,umeå, Sweden, department of epidemiology and social medicine,aarhus university,aarhus, Denmark, the danish cancer society,institute of cancer epidemiology,copenhagen, Denmark, university hospital northern norway,tromsø, Norway, department of epidemiology and public health,imperial college,london, United Kingdom, university of tartu,tartu, Estonia, university of tartu,tartu, Estonia, university of tartu,tartu, Estonia, centre national de génotypage,institut génomique,commissariat à l'énergie atomique,evry, France, centre national de génotypage,institut génomique,commissariat à l'énergie atomique,evry, France, centre national de génotypage,institut génomique,commissariat à l'énergie atomique,evry, France, centre national de génotypage,institut génomique,commissariat à l'énergie atomique,evry, France, centre national de génotypage,institut génomique,commissariat à l'énergie atomique,evry, France, fondation jean dausset-ceph,paris, France, centre national de génotypage,institut génomique,commissariat à l'énergie atomique,evry, France, inserm u557/u1125 inra/cnam,université paris 13,bobigny, France, centre national de génotypage,institut génomique,commissariat à l'énergie atomique,evry, France, international agency for research on cancer (iarc),lyon, France, new york university langone medical center,new york,ny, United States, international agency for research on cancer (iarc),lyon, France, centre national de génotypage,institut génomique,commissariat à l'énergie atomique,evry,france,fondation jean dausset-ceph,paris, France, international agency for research on cancer (iarc),lyon, France



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