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Phenotype restricted genome-wide association study using a gene-centric approach identifies three low-risk neuroblastoma susceptibility loci
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نویسنده
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nguyễn l.b. ,diskin s.j. ,capasso m. ,wang k. ,diamond m.a. ,glessner j. ,kim c. ,attiyeh e.f. ,mosse y.p. ,cole k. ,iolascon a. ,devoto m. ,hakonarson h. ,li h.k. ,maris j.m.
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منبع
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plos genetics - 2011 - دوره : 7 - شماره : 3
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چکیده
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Neuroblastoma is a malignant neoplasm of the developing sympathetic nervous system that is notable for its phenotypic diversity. high-risk patients typically have widely disseminated disease at diagnosis and a poor survival probability,but low-risk patients frequently have localized tumors that are almost always cured with little or no chemotherapy. our genome-wide association study (gwas) has identified common variants within flj22536,bard1,and lmo1 as significantly associated with neuroblastoma and more robustly associated with high-risk disease. here we show that a gwas focused on low-risk cases identified snps within dusp12 at 1q23.3 (p = 2.07×10-6),ddx4 and il31ra both at 5q11.2 (p = 2.94×10-6 and 6.54×10-7 respectively),and hsd17b12 at 11p11.2 (p = 4.20×10-7) as being associated with the less aggressive form of the disease. these data demonstrate the importance of robust phenotypic data in gwas analyses and identify additional susceptibility variants for neuroblastoma. © 2011 nguyễn et al.
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آدرس
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division of oncology and center for childhood cancer research,children's hospital of philadelphia,philadelphia,pa,united states,genomics and computational biology,university of pennsylvania school of medicine,philadelphia,pa,united states,department of biostatistics and epidemiology,university of pennsylvania school of medicine,philadelphia,pa, United States, division of oncology and center for childhood cancer research,children's hospital of philadelphia,philadelphia,pa, United States, department of biochemistry and medical biotechnology,university of naples federico ii,naples,italy,ceinge biotecnologie avanzate,naples, Italy, the center for applied genomics,children's hospital of philadelphia,philadelphia,pa, United States, division of oncology and center for childhood cancer research,children's hospital of philadelphia,philadelphia,pa, United States, the center for applied genomics,children's hospital of philadelphia,philadelphia,pa, United States, the center for applied genomics,children's hospital of philadelphia,philadelphia,pa, United States, division of oncology and center for childhood cancer research,children's hospital of philadelphia,philadelphia,pa,united states,department of pediatrics,university of pennsylvania school of medicine,philadelphia,pa, United States, division of oncology and center for childhood cancer research,children's hospital of philadelphia,philadelphia,pa,united states,department of pediatrics,university of pennsylvania school of medicine,philadelphia,pa, United States, division of oncology and center for childhood cancer research,children's hospital of philadelphia,philadelphia,pa,united states,department of pediatrics,university of pennsylvania school of medicine,philadelphia,pa, United States, department of biochemistry and medical biotechnology,university of naples federico ii,naples,italy,ceinge biotecnologie avanzate,naples, Italy, division of genetics,children's hospital of philadelphia,philadelphia,pa, United States, the center for applied genomics,children's hospital of philadelphia,philadelphia,pa,united states,department of pediatrics,university of pennsylvania school of medicine,philadelphia,pa,united states,division of genetics,children's hospital of philadelphia,philadelphia,pa, United States, department of biostatistics and epidemiology,university of pennsylvania school of medicine,philadelphia,pa, United States, division of oncology and center for childhood cancer research,children's hospital of philadelphia,philadelphia,pa,united states,genomics and computational biology,university of pennsylvania school of medicine,philadelphia,pa,united states,ceinge biotecnologie avanzate,naples,italy,abramson family cancer research institute,university of pennsylvania school of medicine,philadelphia,pa, United States
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Authors
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