plos pathogens سال:2017 - دوره:13

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plos pathogens
سال:2017 - دوره:13 - شماره:10

A conserved fungal glycosyltransferase facilitates pathogenesis of plants by enabling hyphal growth on solid surfaces A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine Attaching and effacing (A/E) lesion formation by enteropathogenic E. coli on human intestinal mucosa is dependent on non-LEE effectors Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling Circadian rhythms in parasites Co-opting ATP-generating glycolytic enzyme PGK1 phosphoglycerate kinase facilitates the assembly of viral replicase complexes Combining epidemiology with basic biology of sand flies,parasites,and hosts to inform leishmaniasis transmission dynamics and control Comparative genomics of geographically distant Fusarium fujikuroi isolates revealed two distinct pathotypes correlating with secondary metabolite profiles Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development Do fungi have an innate immune response? An NLR-based comparison to plant and animal immune systems EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus Enterovirus 71 protease 2Aproand 3Cprodifferentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms,and enterovirus 71 hijacks ERAD component p97 to promote its replication Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection ISG15 governs mitochondrial function in macrophages following vaccinia virus infection In vitro characterization of the antivirulence target of Gram-positive pathogens,peptidoglycan O-acetyltransferase A (OatA) KDM6A addiction of cervical carcinoma cell lines is triggered by E7 and mediated by p21CIP1suppression of replication stress KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation Macavirus latency-associated protein evades immune detection through regulation of protein synthesis in cis depending upon its glycin/glutamate-rich domain Membrane alterations induced by nonstructural proteins of human norovirus Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock Mycobacterium tuberculosis infection modulates adipose tissue biology Parallel and costly changes to cellular immunity underlie the evolution of parasitoid resistance in three Drosophila species Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection Pivotal role for the ESCRT-II complex subunit EAP30/SNF8 in IRF3-dependent innate antiviral defense Reduced accumulation of defective viral genomes contributes to severe outcome in influenza virus infected patients Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection Rice stripe virus NS3 protein regulates primary miRNA processing through association with the miRNA biogenesis factor OsDRB1 and facilitates virus infection in rice Salmonella exploits the host endolysosomal tethering factor HOPS complex to promote its intravacuolar replication Single-cell analysis identifies cellular markers of the HIV permissive cell Sp100 colocalizes with HPV replication foci and restricts the productive stage of the infectious cycle Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition Targeted mutagenesis in a human-parasitic nematode The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut The gastric microbiome,its interaction with Helicobacter pylori,and its potential role in the progression to stomach cancer The immune battlefield: The impact of inflammatory cytokines on CD8+T-cell immunity The yeast form of the fungus Candida albicans promotes persistence in the gut of gnotobiotic mice Toxoplasma gondii induces FAK-Src-STAT3 signaling during infection of host cells that prevents parasite targeting by autophagy miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence