plos genetics سال:2017 - دوره:13

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plos genetics
سال:2017 - دوره:13 - شماره:11

A case-control collapsing analysis identifies epilepsy genes implicated in trio sequencing studies focused on de novo mutations A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation A subset of sweet-sensing neurons identified by IR56d are necessary and sufficient for fatty acid taste Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease CNGCs break through—A rice cyclic nucleotide-gated channel paves the way for pollen tube growth Co-option of the bZIP transcription factor Vrille as the activator of Doublesex1 in environmental sex determination of the crustacean Daphnia magna Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells Epithelial rotation is preceded by planar symmetry breaking of actomyosin and protects epithelial tissue from cell deformations Flip/flop mating-type switching in the methylotrophic yeast Ogataea polymorpha is regulated by an Efg1-Rme1-Ste12 pathway Hippo,TGF-β,and Src-MAPK pathways regulate transcription of the upd3 cytokine in Drosophila enterocytes upon bacterial infection How convincing is a matching Y-chromosome profile? How well do you know your mutation? Complex effects of genetic background on expressivity,complementation,and ordering of allelic effects Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes Natural variation of a sensor kinase controlling a conserved stress response pathway in Escherichia coli Orienting the causal relationship between imprecisely measured traits using GWAS summary data PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex Post-guidance signaling by extracellular matrix-associated Slit/Slit-N maintains fasciculation and position of axon tracts in the nerve cord Regulation of transcription elongation in response to osmostress Reimagining pheromone signalling in the model nematode Caenorhabditis elegans Role of co-repressor genomic landscapes in shaping the Notch response Rv0004 is a new essential member of the mycobacterial DNA replication machinery SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells The combinatorial control of alternative splicing in C. elegans The evolution and adaptation of A-to-I RNA editing The karrikin receptor KAI2 promotes drought resistance in Arabidopsis thaliana The nucleoid as a scaffold for the assembly of bacterial signaling complexes UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay