|
|
|
|
A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation
|
|
|
|
|
|
|
|
نویسنده
|
oakes s.r. ,gallego-ortega d. ,stanford p.m. ,junankar s. ,au w.w.y. ,kikhtyak z. ,von korff a. ,sergio c.m. ,law a.m.k. ,castillo l.e. ,allerdice s.l. ,young a.i.j. ,piggin c. ,whittle b. ,bertram e. ,naylor m.j. ,roden d.l. ,donovan j. ,korennykh a. ,goodnow c.c. ,o’bryan m.k. ,ormandy c.j.
|
|
منبع
|
plos genetics - 2017 - دوره : 13 - شماره : 11
|
|
چکیده
|
We identified a non-synonymous mutation in oas2 (i405n),a sensor of viral double-stranded rna,from an enu-mutagenesis screen designed to discover new genes involved in mammary development. the mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammary glands,characterized by greatly reduced milk protein synthesis coupled with epithelial cell death,inhibition of proliferation and a robust interferon response. expression of mutant but not wild type oas2 in cultured hc-11 or t47d mammary cells recapitulated the phenotypic and transcriptional effects observed in the mouse. the mutation activates the oas2 pathway,demonstrated by a 34-fold increase in rnase l activity,and its effects were dependent on expression of rnase l and irf7,proximal and distal pathway members. this is the first report of a viral recognition pathway regulating lactation. © 2017 oakes et al.
|
|
|
|
|
آدرس
|
garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw,australia,st. vincent’s clinical school,unsw medicine,unsw,sydney,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw,australia,st. vincent’s clinical school,unsw medicine,unsw,sydney,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw,australia,st. vincent’s clinical school,unsw medicine,unsw,sydney,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw, Australia, australian phenomics facility,the australian national universityact, Australia, australian phenomics facility,the australian national universityact, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw,australia,school of medical sciences and bosch institute,sydney medical school,university of sydney,sydney,nsw, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw,australia,st. vincent’s clinical school,unsw medicine,unsw,sydney,nsw, Australia, department of molecular biology,princeton university,princeton,nj, United States, department of molecular biology,princeton university,princeton,nj, United States, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw,australia,st. vincent’s clinical school,unsw medicine,unsw,sydney,nsw,australia,australian phenomics facility,the australian national universityact, Australia, the school of biological sciences,monash university,clayton, Australia, garvan institute of medical research and the kinghorn cancer centre,darlinghurst,nsw,australia,st. vincent’s clinical school,unsw medicine,unsw,sydney,nsw, Australia
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|