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Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor
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نویسنده
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abi ghanem c. ,degerny c. ,hussain r. ,liere p. ,pianos a. ,tourpin s. ,habert r. ,macklin w.b. ,schumacher m. ,ghoumari a.m.
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منبع
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plos genetics - 2017 - دوره : 13 - شماره : 11
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چکیده
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The oligodendrocyte density is greater and myelin sheaths are thicker in the adult male mouse brain when compared with females. here,we show that these sex differences emerge during the first 10 postnatal days,precisely at a stage when a late wave of oligodendrocyte progenitor cells arises and starts differentiating. androgen levels,analyzed by gas chromatography/tandem-mass spectrometry,were higher in males than in females during this period. treating male pups with flutamide,an androgen receptor (ar) antagonist,or female pups with 5α-dihydrotestosterone (5α-dht),revealed the importance of postnatal androgens in masculinizing myelin and their persistent effect into adulthood. a key role of the brain ar in establishing the sexual phenotype of myelin was demonstrated by its conditional deletion. our results uncover a new persistent effect of postnatal ar signaling,with implications for neurodevelopmental disorders and sex differences in multiple sclerosis. © 2017 public library of science. all rights reserved.
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آدرس
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u1195 inserm and universities paris-sud and paris-saclay,80 rue du général leclerc,kremlin-bicêtre, France, u1195 inserm and universities paris-sud and paris-saclay,80 rue du général leclerc,kremlin-bicêtre, France, u1195 inserm and universities paris-sud and paris-saclay,80 rue du général leclerc,kremlin-bicêtre,france,department of neurosurgery,institute for translational neuromedicine,university of rochester,rochester,ny, United States, u1195 inserm and universities paris-sud and paris-saclay,80 rue du général leclerc,kremlin-bicêtre, France, u1195 inserm and universities paris-sud and paris-saclay,80 rue du général leclerc,kremlin-bicêtre, France, u566 inserm,cea,universities paris-diderot and paris-sud,fontenay aux roses, France, u566 inserm,cea,universities paris-diderot and paris-sud,fontenay aux roses, France, department of cell and developmental biology,university of colorado,aurora,co, United States, u1195 inserm and universities paris-sud and paris-saclay,80 rue du général leclerc,kremlin-bicêtre, France, u1195 inserm and universities paris-sud and paris-saclay,80 rue du général leclerc,kremlin-bicêtre, France
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Authors
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