plos genetics سال:2014 - دوره:10

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plos genetics
سال:2014 - دوره:10 - شماره:7

8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage A Broadly Conserved G-Protein-Coupled Receptor Kinase Phosphorylation Mechanism Controls Drosophila Smoothened Activity A Loss of Function Screen of Identified Genome-Wide Association Study Loci Reveals New Genes Controlling Hematopoiesis A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach Accumulation of a Threonine Biosynthetic Intermediate Attenuates General Amino Acid Control by Accelerating Degradation of Gcn4 via Pho85 and Cdk8 Activation of the Arabidopsis thaliana Immune System by Combinations of Common ACD6 Alleles Age-Associated Sperm DNA Methylation Alterations: Possible Implications in Offspring Disease Susceptibility An ARID Domain-Containing Protein within Nuclear Bodies Is Required for Sperm Cell Formation in Arabidopsis thaliana An Essential Nonredundant Role for Mycobacterial DnaK in Native Protein Folding An Intronic microRNA Links Rb/E2F and EGFR Signaling Apomictic and Sexual Germline Development Differ with Respect to Cell Cycle,Transcriptional,Hormonal and Epigenetic Regulation Arabidopsis DELLA Protein Degradation Is Controlled by a Type-One Protein Phosphatase,TOPP4 Arabidopsis thaliana WAPL Is Essential for the Prophase Removal of Cohesin during Meiosis Brg1 Loss Attenuates Aberrant Wnt-Signalling and Prevents Wnt-Dependent Tumourigenesis in the Murine Small Intestine Cis and Trans Effects of Human Genomic Variants on Gene Expression Clonal Architecture of Secondary Acute Myeloid Leukemia Defined by Single-Cell Sequencing Combinatorial Interactions Are Required for the Efficient Recruitment of Pho Repressive Complex (PhoRC) to Polycomb Response Elements Common Transcriptional Mechanisms for Visual Photoreceptor Cell Differentiation among Pancrustaceans Comparative Phylogenomics Uncovers the Impact of Symbiotic Associations on Host Genome Evolution Comparison of Methods to Account for Relatedness in Genome-Wide Association Studies with Family-Based Data Correction to Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke (PLoS Genet,(2014),10,7 (e1004571),10.1371/journal.pgen.1004571) Correction to Integrative Modeling of eQTLs and Cis-Regulatory Elements Suggests Mechanisms Underlying Cell Type Specificity of eQTLs (PLoS Genet,(2014),10,7 (e1004546),10.1371/journal.pgen.1004546) Correction to Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype (PLoS Genet,(2014),10,7 (e1004538),10.1371/journal.pgen.1004538) Cuba: Exploring the History of Admixture and the Genetic Basis of Pigmentation Using Autosomal and Uniparental Markers DNA Topoisomerase 1α Promotes Transcriptional Silencing of Transposable Elements through DNA Methylation and Histone Lysine 9 Dimethylation in Arabidopsis Determinative Developmental Cell Lineages Are Robust to Cell Deaths Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein Aggregates Evolution and Genetic Architecture of Chromatin Accessibility and Function in Yeast Functional Diversification of Hsp40: Distinct J-Protein Functional Requirements for Two Prions Allow for Chaperone-Dependent Prion Selection Functional EF-Hands in Neuronal Calcium Sensor GCAP2 Determine Its Phosphorylation State and Subcellular Distribution In Vivo,and Are Essential for Photoreceptor Cell Integrity Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin Hypersensitivity of Primordial Germ Cells to Compromised Replication-Associated DNA Repair Involves ATM-p53-p21 Signaling Hypoxia Adaptations in the Grey Wolf (Canis lupus chanco) from Qinghai-Tibet Plateau Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease Intrapopulation Genome Size Variation in D. melanogaster Reflects Life History Variation and Plasticity Knock-In Reporter Mice Demonstrate that DNA Repair by Non-homologous End Joining Declines with Age LIN-42,the Caenorhabditis elegans PERIOD homolog,Negatively Regulates MicroRNA Transcription MDRL lncRNA Regulates the Processing of miR-484 Primary Transcript by Targeting miR-361 Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis Meiosis-Specific Cohesin Component,Stag3 Is Essential for Maintaining Centromere Chromatid Cohesion,and Required for DNA Repair and Synapsis between Homologous Chromosomes Microsatellite Interruptions Stabilize Primate Genomes and Exist as Population-Specific Single Nucleotide Polymorphisms within Individual Human Genomes Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index - صفحه:1-12 Nucleosomes Shape DNA Polymorphism and Divergence Recombination in the Human Pseudoautosomal Region PAR1 Regulation of Feto-Maternal Barrier by Matriptase- and PAR-2-Mediated Signaling Is Required for Placental Morphogenesis and Mouse Embryonic Survival Requirements for Pseudomonas aeruginosa Acute Burn and Chronic Surgical Wound Infection Silencing Is Noisy: Population and Cell Level Noise in Telomere-Adjacent Genes Is Dependent on Telomere Position and Sir2 SlmA Antagonism of FtsZ Assembly Employs a Two-pronged Mechanism like MinCD Sox11 Is Required to Maintain Proper Levels of Hedgehog Signaling during Vertebrate Ocular Morphogenesis Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development The Co-factor of LIM Domains (CLIM/LDB/NLI) Maintains Basal Mammary Epithelial Stem Cells and Promotes Breast Tumorigenesis The Coding and Noncoding Architecture of the Caulobacter crescentus Genome The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation The Nesprin Family Member ANC-1 Regulates Synapse Formation and Axon Termination by Functioning in a Pathway with RPM-1 and β-Catenin The PTK7-Related Transmembrane Proteins Off-track and Off-track 2 Are Co-receptors for Drosophila Wnt2 Required for Male Fertility The Two Cis-Acting Sites,parS1 and oriC1,Contribute to the Longitudinal Organisation of Vibrio cholerae Chromosome I UVB Induces a Genome-Wide Acting Negative Regulatory Mechanism That Operates at the Level of Transcription Initiation in Human Cells Unraveling Genetic Modifiers in the Gria4 Mouse Model of Absence Epilepsy Wnt Signaling Interacts with Bmp and Edn1 to Regulate Dorsal-Ventral Patterning and Growth of the Craniofacial Skeleton zic-1 Expression in Planarian Neoblasts after Injury Controls Anterior Pole Regeneration