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Hypoxia Adaptations in the Grey Wolf (Canis lupus chanco) from Qinghai-Tibet Plateau
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نویسنده
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zhang w. ,fan z. ,han e. ,hou r. ,zhang l. ,galaverni m. ,huang j. ,liu h. ,silva p. ,li p. ,pollinger j.p. ,du l. ,zhang x.y. ,yue b. ,wayne r.k. ,zhang z.
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منبع
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plos genetics - 2014 - دوره : 10 - شماره : 7
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چکیده
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The tibetan grey wolf (canis lupus chanco) occupies habitats on the qinghai-tibet plateau,a high altitude (>3000 m) environment where low oxygen tension exerts unique selection pressure on individuals to adapt to hypoxic conditions. to identify genes involved in hypoxia adaptation,we generated complete genome sequences of nine chinese wolves from high and low altitude populations at an average coverage of 25× coverage. we found that,beginning about 55,000 years ago,the highland tibetan grey wolf suffered a more substantial population decline than lowland wolves. positively selected hypoxia-related genes in highland wolves are enriched in the hif signaling pathway (p = 1.57e-6),atp binding (p = 5.62e-5),and response to an oxygen-containing compound (p≤5.30e-4). of these positively selected hypoxia-related genes,three genes (epas1,angpt1,and ryr2) had at least one specific fixed non-synonymous snp in highland wolves based on the nine genome data. our re-sequencing studies on a large panel of individuals showed a frequency difference greater than 58% between highland and lowland wolves for these specific fixed non-synonymous snps and a high degree of ld surrounding the three genes,which imply strong selection. past studies have shown that epas1 and angpt1 are important in the response to hypoxic stress,and ryr2 is involved in heart function. these three genes also exhibited significant signals of natural selection in high altitude human populations,which suggest similar evolutionary constraints on natural selection in wolves and humans of the qinghai-tibet plateau. © 2014 zhang et al.
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آدرس
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sichuan key laboratory of conservation biology on endangered wildlife,chengdu research base of giant panda breeding,chengdu,sichuan province,china,department of ecology and evolutionary biology,ucla,los angeles,ca, United States, department of ecology and evolutionary biology,ucla,los angeles,ca,united states,key laboratory of bioresources and ecoenvironment (ministry of education),college of life sciences,sichuan university,chengdu, China, department of ecology and evolutionary biology,ucla,los angeles,ca, United States, sichuan key laboratory of conservation biology on endangered wildlife,chengdu research base of giant panda breeding,chengdu,sichuan province, China, sichuan key laboratory of conservation biology on endangered wildlife,chengdu research base of giant panda breeding,chengdu,sichuan province, China, ispra,ozzano dell'emilia, Italy, sichuan key laboratory of conservation biology on endangered wildlife,college of life sciences,sichuan university,chengdu, China, sichuan key laboratory of conservation biology on endangered wildlife,chengdu research base of giant panda breeding,chengdu,sichuan province, China, cibio-up,university of porto,vairão, Portugal, sichuan key laboratory of conservation biology on endangered wildlife,college of life sciences,sichuan university,chengdu, China, department of ecology and evolutionary biology,ucla,los angeles,ca, United States, sichuan key laboratory of conservation biology on endangered wildlife,college of life sciences,sichuan university,chengdu, China, key laboratory of bioresources and ecoenvironment (ministry of education),college of life sciences,sichuan university,chengdu, China, key laboratory of bioresources and ecoenvironment (ministry of education),college of life sciences,sichuan university,chengdu, China, department of ecology and evolutionary biology,ucla,los angeles,ca, United States, sichuan key laboratory of conservation biology on endangered wildlife,chengdu research base of giant panda breeding,chengdu,sichuan province, China
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Authors
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