plos genetics سال:2012 - دوره:8

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plos genetics
سال:2012 - دوره:8 - شماره:6

A SEL1L mutation links a canine progressive early-onset cerebellar ataxia to the endoplasmic reticulum-associated protein degradation (ERAD) machinery A broad requirement for TLS polymerases η and κ,and interacting sumoylation and nuclear pore proteins,in lesion bypass during C. elegans embryogenesis A mouse model of acrodermatitis enteropathica: Loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity Adaptive introgression across species boundaries in Heliconius butterflies An engineering approach to extending lifespan in C. elegans Attenuation of Notch and hedgehog signaling is required for fate specification in the spinal cord Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants Cohesin proteins promote ribosomal RNA production and protein translation in yeast and human cells Decreased mitochondrial DNA mutagenesis in human colorectal cancer Divergence of the yeast transcription factor FZF1 affects sulfite resistance Diverse CRISPRs evolving in human microbiomes Dual-level regulation of ACC synthase activity by MPK3/MPK6 cascade and its downstream WRKY transcription factor during ethylene induction in arabidopsis Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection Found: The elusive ANTAR transcription antiterminator Fuzzy tandem repeats containing p53 response elements may define species-specific p53 target genes G protein activation without a GEF in the plant kingdom Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation Genetic variants on chromosome 1q41 influence ocular axial length and high myopia Genome-wide functional profiling identifies genes and processes important for zinc-limited growth of Saccharomyces cerevisiae Genome-wide identification of ampicillin resistance determinants in enterococcus faecium Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2 Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis Global regulatory functions of the Staphylococcus aureus endoribonuclease III in gene expression Gustatory perception and fat body energy metabolism are jointly affected by vitellogenin and juvenile hormone in honey bees In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases In vivo effects of histone H3 depletion on nucleosome occupancy and position in Saccharomyces cerevisiae Incompatibility and competitive exclusion of genomic segments between sibling Drosophila species Interplay between synaptonemal complex,homologous recombination,and centromeres during mammalian meiosis Limits to the rate of adaptive substitution in sexual populations MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells Mimetic butterflies introgress to impress Parallel evolution of auditory genes for echolocation in bats and toothed whales Patterns of evolutionary conservation of essential genes correlate with their compensability Phylogenomic analysis reveals dynamic evolutionary history of the Drosophila heterochromatin protein 1 (HP1) gene family Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2 Quantifying the adaptive potential of an antibiotic resistance enzyme RNA methylation by the MIS complex regulates a cell fate decision in yeast Rare copy number variants observed in hereditary breast cancer cases disrupt genes in estrogen signaling and TP53 tumor suppression network Rumors of its disassembly have been greatly exaggerated: The secret life of the synaptonemal complex at the centromeres Selection-driven gene loss in bacteria Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection Stretching the rules: Monocentric chromosomes with multiple centromere domains Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends The CCR4-NOT complex is implicated in the viability of aneuploid yeasts The NSL complex regulates housekeeping genes in Drosophila The Rad4TopBP1 ATR-activation domain functions in G1/S phase in a chromatin-dependent manner The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb morphology and defective sperm motility The histone demethylase Jhdm1a regulates hepatic gluconeogenesis The mechanism for RNA recognition by ANTAR regulators of gene expression The regulatory network of natural competence and transformation of Vibrio cholerae Tipping the balance in the powerhouse of the cell to protect colorectal cancer Uracil-containing DNA in Drosophila: Stability,stage-specific accumulation,and developmental involvement sox9b is a key regulator of pancreaticobiliary ductal system development