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Genetic variants on chromosome 1q41 influence ocular axial length and high myopia
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نویسنده
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fan q. ,barathi v.a. ,cheng c.-y. ,zhou x. ,meguro a. ,nakata i. ,khor c.-c. ,goh l.-k. ,li y.-j. ,lim w. ,ho c.e.h. ,hawthorne f. ,zheng y. ,chua d. ,inoko h. ,yamashiro k. ,ohno-matsui k. ,matsuo k. ,matsuda f. ,vithana e. ,seielstad m. ,mizuki n. ,beuerman r.w. ,tai e. ,yoshimura n. ,aung t. ,young t.l. ,wong t.-y. ,teo y.-y. ,saw s.-m.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 6
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چکیده
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As one of the leading causes of visual impairment and blindness,myopia poses a significant public health burden in asia. the primary determinant of myopia is an elongated ocular axial length (al). here we report a meta-analysis of three genome-wide association studies on al conducted in 1,860 chinese adults,929 chinese children,and 2,155 malay adults. we identified a genetic locus on chromosome 1q41 harboring the zinc-finger 11b pseudogene zc3h11b showing genome-wide significant association with al variation (rs4373767,β = -0.16 mm per minor allele,pmeta = 2.69×10-10). the minor c allele of rs4373767 was also observed to significantly associate with decreased susceptibility to high myopia (per-allele odds ratio (or) = 0.75,95% ci: 0.68-0.84,pmeta = 4.38×10-7) in 1,118 highly myopic cases and 5,433 controls. zc3h11b and two neighboring genes slc30a10 and lyplal1 were expressed in the human neural retina,retinal pigment epithelium,and sclera. in an experimental myopia mouse model,we observed significant alterations to gene and protein expression in the retina and sclera of the unilateral induced myopic eyes for the murine genes zc3h11a,slc30a10,and lyplal1. this supports the likely role of genetic variants at chromosome 1q41 in influencing al variation and high myopia. © 2012 fan et al.
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آدرس
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saw swee hock school of public health,national university of singapore,singapore, Singapore, singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore, Singapore, saw swee hock school of public health,national university of singapore,singapore,singapore,singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore, Singapore, saw swee hock school of public health,national university of singapore,singapore, Singapore, department of ophthalmology,yokohama city university school of medicine,yokohama, Japan, department of ophthalmology,kyoto university graduate school of medicine,kyoto,japan,center for genomic medicine and inserm u.852,kyoto university graduate school of medicine,kyoto, Japan, singapore eye research institute,singapore national eye centre,singapore,singapore,genome institute of singapore,agency for science,technology,and research,singapore,singapore,centre for molecular epidemiology,national university of singapore,singapore,singapore,department of pediatrics,national university of singapore,singapore, Singapore, saw swee hock school of public health,national university of singapore,singapore,singapore,duke-national university of singapore graduate medical school,singapore,singapore,department of medical oncology,national cancer centre singapore,singapore, Singapore, department of biostatistics and bioinformatics,duke university medical school,durham,nc,united states,center for human genetics,duke university medical center,durham,nc, United States, singapore eye research institute,singapore national eye centre,singapore, Singapore, singapore eye research institute,singapore national eye centre,singapore, Singapore, center for human genetics,duke university medical center,durham,nc, United States, singapore eye research institute,singapore national eye centre,singapore, Singapore, singapore eye research institute,singapore national eye centre,singapore, Singapore, department of molecular life science,division of molecular medical science and molecular medicine,tokai university school of medicine,isehara, Japan, department of ophthalmology,kyoto university graduate school of medicine,kyoto, Japan, department of ophthalmology and visual science,graduate school of medicine,tokyo medical and dental university,tokyo, Japan, division of epidemiology and prevention,aichi cancer center research institute,nagoya, Japan, center for genomic medicine and inserm u.852,kyoto university graduate school of medicine,kyoto, Japan, singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore, Singapore, institute for human genetics and department of laboratory medicine,university of california san francisco,san francisco,ca, United States, department of ophthalmology,yokohama city university school of medicine,yokohama, Japan, singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore,singapore,duke-national university of singapore graduate medical school,singapore, Singapore, saw swee hock school of public health,national university of singapore,singapore,singapore,department of medicine,national university of singapore,singapore, Singapore, department of ophthalmology,kyoto university graduate school of medicine,kyoto, Japan, singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore, Singapore, duke-national university of singapore graduate medical school,singapore,singapore,center for human genetics,duke university medical center,durham,nc, United States, saw swee hock school of public health,national university of singapore,singapore,singapore,singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore,singapore,centre for eye research australia,university of melbourne,melbourne, Australia, saw swee hock school of public health,national university of singapore,singapore,singapore,genome institute of singapore,agency for science,technology,and research,singapore,singapore,graduate school for integrative science and engineering,national university of singapore,singapore,singapore,department of statistics and applied probability,national university of singapore,singapore, Singapore, saw swee hock school of public health,national university of singapore,singapore,singapore,singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore,singapore,duke-national university of singapore graduate medical school,singapore,singapore,graduate school for integrative science and engineering,national university of singapore,singapore, Singapore
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Authors
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