plos genetics سال:2011 - دوره:7

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plos genetics
سال:2011 - دوره:7 - شماره:9

A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in caenorhabditis elegans A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci A genome-wide metabolic QTL analysis in europeans implicates two Loci shaped by recent positive selection A negative feedback loop that limits the ectopic activation of a cell type-specific sporulation sigma factor of bacillus subtilis A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice Age-dependent recombination rates in human pedigrees An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development Association of eGFR-related loci identified by GWAS with incident CKD and ESRD Atypical AT skew in Firmicute genomes results from selection and not from mutation Bacterial communities of diverse Drosophila species: Ecological context of a host-microbe model system Bmp and Nodal independently regulate lefty1 expression to maintain unilateral Nodal activity during left-right axis specification in zebrafish Caenorhabditis elegans histone methyltransferase MET-2 shields the male X chromosome from checkpoint machinery and mediates meiotic sex chromosome inactivation Cell type-specific transcriptome analysis reveals a major role for Zeb1 and miR-200b in mouse inner ear morphogenesis Cholesterol metabolism is required for intracellular Hedgehog signal transduction in vivo Comparative and functional genomics of Rhodococcus opacus PD630 for Biofuels development Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation Elevated proteasome capacity extends replicative lifespan in saccharomyces cerevisiae Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification Emergence and modular evolution of a novel motility machinery in bacteria Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes Genetic association for renal traits among participants of African Ancestry reveals new loci for renal function Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations Genetic variants at chromosomes 2q35,5p12,6q25.1,10q26.13,and 16q12.1 influence the risk of breast cancer in men Genome-wide analysis of heteroduplex DNA in mismatch repair-deficient yeast cells reveals novel properties of meiotic recombination pathways Genome-wide association study identifies four loci associated with eruption of permanent teeth Genomic analysis of QTLs and genes altering natural variation in stochastic noise Germline genetic variants disturbing the let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice Identification of type 1 Diabetes-associated DNA methylation variable positions that precede disease diagnosis Inactivation of PMEL alters melanosome shape but has only a subtle effect on visible pigmentation Inference of relationships in population data using identity-by-descent and identity-by-state Inter-allelic prion propagation reveals conformational relationships among a multitude of [PSI] strains Large-scale gene-centric analysis identifies novel variants for coronary artery disease MicroRNA predictors of longevity in caenorhabditis elegans Misregulation of Scm3p/HJURP causes chromosome instability in saccharomyces cerevisiae and human cells Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic Novel interactions between actin and the proteasome revealed by complex haploinsufficiency PCNA ubiquitination is important,but not essential for translesion DNA synthesis in mammalian cells Phased whole-genome genetic risk in a family quartet using a major allele reference sequence Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms Separation of recombination and SOS response in Escherichia coli RecA suggests LexA interaction sites Sequence conservation and functional constraint on intergenic spacers in reduced genomes of the obligate symbiont Buchnera Sex chromosome mosaicism and hybrid speciation among tiger swallowtail butterflies Study of foxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development Temporal trends in results availability from genome-wide association studies The abnormal phenotypes of cartilage and bone in calcium-sensing receptor deficient mice are dependent on the actions of calcium,phosphorus,and PTH The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO The receptor tyrosine kinase alk controls neurofibromin functions in drosophila growth and learning Transcriptome kinetics is governed by a genome-wide coupling of mRNA production and degradation: A role for RNA pol II Tsx produces a long noncoding RNA and has general functions in the germline,stem cells,and brain VANG-1 and PRKL-1 cooperate to negatively regulate neurite formation in Caenorhabditis elegans