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Association of eGFR-related loci identified by GWAS with incident CKD and ESRD
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نویسنده
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böger c.a. ,gorski m. ,li m. ,hoffmann m.m. ,huang c. ,yang q. ,teumer a. ,krane v. ,o'seaghdha c.m. ,kutalik z. ,wichmann h.-e. ,haak t. ,boes e. ,coassin s. ,coresh j. ,kollerits b. ,haun m. ,paulweber b. ,köttgen a. ,li g. ,shlipak m.g. ,powe n. ,hwang s.-j. ,dehghan a. ,rivadeneira f. ,uitterlinden a. ,hofman a. ,beckmann j.s. ,krämer b.k. ,witteman j. ,bochud m. ,siscovick d. ,rettig r. ,kronenberg f. ,wanner c. ,thadhani r.i. ,heid i.m. ,fox c.s. ,kao w.h.
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منبع
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plos genetics - 2011 - دوره : 7 - شماره : 9
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چکیده
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Family studies suggest a genetic component to the etiology of chronic kidney disease (ckd) and end stage renal disease (esrd). previously,we identified 16 loci for egfr in genome-wide association studies,but the associations of these single nucleotide polymorphisms (snps) for incident ckd or esrd are unknown. we thus investigated the association of these loci with incident ckd in 26,308 individuals of european ancestry free of ckd at baseline drawn from eight population-based cohorts followed for a median of 7.2 years (including 2,122 incident ckd cases defined as egfr <60ml/min/1.73m2 at follow-up) and with esrd in four case-control studies in subjects of european ancestry (3,775 cases,4,577 controls). snps at 11 of the 16 loci (umod,prkag2,anxa9,dab2,shroom3,dach1,stc1,slc34a1,alms1/nat8,ube2q2,and gckr) were associated with incident ckd; p-values ranged from p = 4.1e-9 in umod to p = 0.03 in gckr. after adjusting for baseline egfr,six of these loci remained significantly associated with incident ckd (umod,prkag2,anxa9,dab2,dach1,and stc1). snps in umod (or = 0.92,p = 0.04) and gckr (or = 0.93,p = 0.03) were nominally associated with esrd. in summary,the majority of egfr-related loci are either associated or show a strong trend towards association with incident ckd,but have modest associations with esrd in individuals of european descent. additional work is required to characterize the association of genetic determinants of ckd and esrd at different stages of disease progression.
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آدرس
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department of internal medicine ii,university hospital regensburg,regensburg, Germany, department of epidemiology and preventive medicine,university hospital regensburg,regensburg,germany,institute of epidemiology i,helmholtz zentrum münchen,german research center for environmental health,neuherberg, Germany, department of epidemiology,johns hopkins bloomberg school of public health,baltimore,md, United States, clinical chemistry,university medical center freiburg,university of freiburg,freiburg, Germany, division of nephrology,massachusetts general hospital,boston,ma, United States, department of biostatistics,boston university school of public health,boston,ma, United States, interfaculty institute for genetics and functional genomics,university of greifswald,greifswald, Germany, university of würzburg,department of medicine 1,division of nephrology,university hospital würzburg,würzburg, Germany, division of nephrology,brigham and women's hospital and harvard medical school,boston,ma,united states,nhlbi's framingham heart study and the center for population studies,framingham,ma, United States, department of medical genetics,university of lausanne,lausanne,switzerland,swiss institute of bioinformatics,lausanne, Switzerland, institute of epidemiology i,helmholtz zentrum münchen,german research center for environmental health,neuherberg,germany,institute of medical informatics,biometry,and epidemiology,ludwig-maximilians-universität,munich,germany,klinikum großhadern,munich, Germany, diabetes klinik bad mergentheim,bad mergentheim, Germany, innsbruck medical university,division of genetic epidemiology,innsbruck, Austria, innsbruck medical university,division of genetic epidemiology,innsbruck, Austria, department of epidemiology and welch center for prevention,epidemiology,and clinical research,johns hopkins bloomberg school of public health,baltimore,md, United States, innsbruck medical university,division of genetic epidemiology,innsbruck, Austria, innsbruck medical university,division of genetic epidemiology,innsbruck, Austria, first department of internal medicine,paracelsus medical university,salzburg, Austria, department of epidemiology,johns hopkins bloomberg school of public health,baltimore,md,united states,renal division,university hospital of freiburg,freiburg, Germany, department of medicine,university of washington,seattle,wa, United States, division of general internal medicine,san francisco va medical center,san francisco,ca,united states,department of medicine,epidemiology,and biostatistics,university of california san francisco,san francisco,ca, United States, department of medicine,san francisco general hospital,university of california san francisco,san francisco,ca, United States, nhlbi's framingham heart study and the center for population studies,framingham,ma, United States, department of epidemiology,erasmus medical center,rotterdam,netherlands,member of netherlands consortium for healthy aging (ncha),netherlands genomics initiative (ngi),leiden, Netherlands, member of netherlands consortium for healthy aging (ncha),netherlands genomics initiative (ngi),leiden,netherlands,department of internal medicine,erasmus medical center,rotterdam, Netherlands, member of netherlands consortium for healthy aging (ncha),netherlands genomics initiative (ngi),leiden,netherlands,department of internal medicine,erasmus medical center,rotterdam, Netherlands, department of epidemiology,erasmus medical center,rotterdam,netherlands,member of netherlands consortium for healthy aging (ncha),netherlands genomics initiative (ngi),leiden, Netherlands, service of medical genetics,centre hospitalier universitaire vaudois and department of medical genetics,university of lausanne,lausanne, Switzerland, university medical centre mannheim,5th department of medicine,mannheim, Germany, department of epidemiology,erasmus medical center,rotterdam,netherlands,member of netherlands consortium for healthy aging (ncha),netherlands genomics initiative (ngi),leiden, Netherlands, university institute of social and preventive medicine,centre hospitalier universitaire vaudois,university of lausanne,lausanne, Switzerland, cardiovascular health research unit,departments of epidemiology and medicine,university of washington,seattle,wa, United States, institute of physiology,university of greifswald,greifswald, Germany, innsbruck medical university,division of genetic epidemiology,innsbruck, Austria, university of würzburg,department of medicine 1,division of nephrology,university hospital würzburg,würzburg, Germany, division of nephrology,massachusetts general hospital,boston,ma, United States, department of epidemiology and preventive medicine,university hospital regensburg,regensburg,germany,institute of epidemiology i,helmholtz zentrum münchen,german research center for environmental health,neuherberg, Germany, nhlbi's framingham heart study and the center for population studies,framingham,ma,united states,division of endocrinology,brigham and women's hospital and harvard medical school,boston,ma, United States, department of epidemiology and welch center for prevention,epidemiology,and clinical research,johns hopkins bloomberg school of public health,baltimore,md, United States
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Authors
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