journal of experimental and clinical cancer research سال:2016 - دوره:35

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journal of experimental and clinical cancer research
سال:2016 - دوره:35 - شماره:1

1-methylnicotinamide and its structural analog 1,4-dimethylpyridine for the prevention of cancer metastasis A novel long non-coding RNA lnc-GNAT1-1 is low expressed in colorectal cancer and acts as a tumor suppressor through regulating RKIP-NF-κB-Snail circuit A panel of four genes accurately differentiates benign from malignant thyroid nodules - صفحه:1-8 A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells A restricted signature of serum miRNAs distinguishes glioblastoma from lower grade gliomas ATF2 predicts poor prognosis and promotes malignant phenotypes in renal cell carcinoma Activation of the JNK-c-Jun pathway in response to irradiation facilitates Fas ligand secretion in hepatoma cells and increases hepatocyte injury Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro Alternative scheduling of pulsatile,high dose sunitinib efficiently suppresses tumor growth Anti-tumor effects of Atractylenolide i on bladder cancer cells Anti-tumor effects of pigment epithelium-derived factor (PEDF): Implication for cancer therapy. A mini-review Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A,Aurora B and VEGFR2 kinases - صفحه:1-15 Atorvastatin (Lipitor) attenuates the effects of aspirin on pancreatic cancerogenesis and the chemotherapeutic efficacy of gemcitabine on pancreatic cancer by promoting M2 polarized tumor associated macrophages Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cγ1 and the ERK1/2 pathway Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer Brain stereotactic biopsy flow cytometry for central nervous system lymphoma characterization: Advantages and pitfalls CCDC88A,a prognostic factor for human pancreatic cancers,promotes the motility and invasiveness of pancreatic cancer cells CCR7 mediates the TNF-α-induced lymphatic metastasis of gallbladder cancer through the eRK1/2 - AP-1 and jNK - AP-1 pathways CD146 promotes metastasis and predicts poor prognosis of hepatocellular carcinoma CD317 Promotes the survival of cancer cells through apoptosis-inducing factor Cell cycle checkpoint in cancer: A therapeutically targetable double-edged sword Characterization of DNA topoisomerase i in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistanceassociated mutations Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization Combined therapy with oncolytic adenoviruses encoding TRAIL and IL-12 genes markedly suppressed human hepatocellular carcinoma both in vitro and in an orthotopic transplanted mouse model DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27 Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer Development of a methodology for in vivo follow-up of hepatocellular carcinoma in hepatocyte specific Trim24-null mice treated with myo-inositol trispyrophosphate Direct targeting sperm-associated antigen 9 by miR-141 influences hepatocellular carcinoma cell growth and metastasis via JNK pathway Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol Dysregulation of microRNA biogenesis in cancer: The impact of mutant p53 on Drosha complex activity EEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts Efficacy and safety of aflibercept in in vitro and in vivo models of retinoblastoma - صفحه:1-10 Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node,intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase Elevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1 Elevated MTSS1 expression associated with metastasis and poor prognosis of residual hepatitis B-related hepatocellular carcinoma Eliciting cytotoxic T lymphocytes against human laryngeal cancer-derived antigens: Evaluation of dendritic cells pulsed with a heat-treated tumor lysate and other antigen-loading strategies for dendritic-cell-based vaccination Emerging role of epithelial-mesenchymal transition in hepatic cancer Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation,epigenetic modifiers,and differentiation-inducing drugs Enhanced stimulation of anti-breast cancer T cells responses by dendritic cells loaded with poly lactic-co-glycolic acid (PLGA) nanoparticle encapsulated tumor antigens - صفحه:1-11 Enhanced therapeutic effect of an antiangiogenesis peptide on lung cancer in vivo combined with salmonella VNP20009 carrying a Sox2 shRNA construct Enhancement of anti-tumor effects of 5-fluorouracil on hepatocellular carcinoma by low-intensity ultrasound EphA1 activation promotes the homing of endothelial progenitor cells to hepatocellular carcinoma for tumor neovascularization through the SDF-1/CXCR4 signaling pathway Epidermal growth factor (EGF) receptor-ligand based molecular staging predicts prognosis in head and neck squamous cell carcinoma partly due to deregulated EGF- induced amphiregulin expression Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells Erratum : Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer (J Exp Clin Cancer Res (2016) 35 (135) DOI: 10.1186/s13046-016-0410-3) - صفحه:1-1 Erratum: Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer ( Journal of Experimental and Clinical Cancer Research(2016) 35:1 (70) DOI: 10.1186/s13046-016-0347-6) Erratum: Combined therapy with oncolytic adenoviruses encoding TRAIL and IL-12 genes markedly suppressed human hepatocellular carcinoma both in vitro and in an orthotopic transplanted mouse model (Journal of Experimental and Clinical Cancer Research (2016) 35:1 (74) DOI: 10.1186/s13046-016-0353-8) Erratum: Elevated MTSS1 expression associated with metastasis and poor prognosis of residual hepatitis B-related hepatocellular carcinoma (Journal of Experimental and Clinical Cancer Research (2016) 35:1 (85) DOI:10.1186/s13046-016-0361-8) Erratum: Heregulin-1ß and HER3 in hepatocellular carcinoma: Status and regulation by insulin (Journal of Experimental and Clinical Cancer Research (2016) 35 (126) DOI: 10.1186/s13046-016-0402-3) Erratum: Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells (Journal of Experimental and Clinical Cancer Research (2016) 35:1 (59) DOI: 10.1186/s13046-016-0330-2) Erratum: Linc00152 promotes proliferation in gastric cancer through the EGFR-dependent pathway Erratum: Pancreatic cancer cell-derived IGFBP-3 contributes to muscle wasting (Journal of Experimental and Clinical Cancer Research (2016) 35:1 (46) DOI: 10.1186/s13046-016-0317-z) Erratum: Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells (Journal of Experimental and Clinical Cancer Research (2016) 35 (7) DOI: 10.1186/s13046-016-0299-x) Evaluation of intraarterial and intravenous cisplatin chemotherapy in the treatment of metastatic osteosarcoma using an orthotopic xenograft mouse model Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro - صفحه:1-12 Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer - صفحه:1-10 FLIPL is critical for aerobic glycolysis in hepatocellular carcinoma First-line therapy in HER2 positive metastatic breast cancer: Is the mosaic fully completed or are we missing additional pieces? Flow cytometry remission by Ig light chains ratio is a powerful marker of outcome in multiple myeloma after tandem autologous transplant: A real-life study From pathogenesis to clinical application: Insights into exosomes as transfer vectors in cancer - صفحه:1-12 GANT61,a GLI inhibitor,sensitizes glioma cells to the temozolomide treatment - صفحه:1-14 Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer Galectin-1 from cancer-associated fibroblasts induces epithelial-mesenchymal transition through β1 integrin-mediated upregulation of Gli1 in gastric cancer - صفحه:1-13 Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy Growth differentiation factor 15 contributes to cancer-associated fibroblasts-mediated chemo-protection of AML cells HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability Heat shock protein 70-2 (HSP70-2) overexpression in breast cancer - صفحه:1-14 Hepatitis B virus X protein promotes interleukin-7 receptor expression via NF-κB and Notch1 pathway to facilitate proliferation and migration of hepatitis B virus-related hepatoma cells - صفحه:1-14 Hepatitis B virus whole-X and X protein play distinct roles in HBV-related hepatocellular carcinoma progression Heregulin-1ß and HER3 in hepatocellular carcinoma: Status and regulation by insulin High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-Acute lymphoblastic leukemia High expression of long non-coding RNA SBF2-AS1 promotes proliferation in non-small cell lung cancer Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signaling pathways Induction of the mesenchymal to epithelial transition by demethylation-activated microRNA-125b is involved in the anti-migration/invasion effects of arsenic trioxide on human chondrosarcoma Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin i Inhibition of SALL4 reduces tumorigenicity involving epithelial-mesenchymal transition via Wnt/β-catenin pathway in esophageal squamous cell carcinoma Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing's sarcoma through the PI3K/Akt pathway Inhibition of YAP suppresses CML cell proliferation and enhances efficacy of imatinib in vitro and in vivo Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase i and topoisomerase II Integrated analysis of microRNA regulatory network in nasopharyngeal carcinoma with deep sequencing Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells Interleukin-37 suppresses tumor growth through inhibition of angiogenesis in non-small cell lung cancer Interleukin-9 promotes cell survival and drug resistance in diffuse large B-cell lymphoma Interplay between intergrin-linked kinase and ribonuclease inhibitor affects growth and metastasis of bladder cancer through signaling ILK pathways JunB promotes cell invasion,migration and distant metastasis of head and neck squamous cell carcinoma LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC LRG1 modulates epithelial-mesenchymal transition and angiogenesis in colorectal cancer via HIF-1α activation Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2 Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a Long non-coding RNA H19 regulates FOXM1 expression by competitively binding endogenous miR-342-3p in gallbladder cancer - صفحه:1-12 Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression Long noncoding RNA NEAT1 promotes laryngeal squamous cell cancer through regulating miR-107/CDK6 pathway Low dose of lenalidmide and PI3K/mTOR inhibitor trigger synergistic cytoxicity in activated B cell-like subtype of diffuse large B cell lymphoma MIR-130a-3p regulates cell migration and invasion via inhibition of Smad4 in gemcitabine resistant hepatoma cells MIR-302a/b/c/d cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein(P-gp) by targeting MAP/ERK kinase kinase 1 (MEKK1) MIR-539 inhibits prostate cancer progression by directly targeting SPAG5 Maspin enhances cisplatin chemosensitivity in bladder cancer T24 and 5637 cells and correlates with prognosis of muscle-invasive bladder cancer patients receiving cisplatin based neoadjuvant chemotherapy MiR-137 and miR-34a directly target Snail and inhibit EMT,invasion and sphere-forming ability of ovarian cancer cells MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression MiR-548c impairs migration and invasion of endometrial and ovarian cancer cells via downregulation of Twist MiRNA-106a directly targeting RARB associates with the expression of Na+/I- symporter in thyroid cancer by regulating MAPK signaling pathway MicroRNA-106b is involved in transforming growth factor β1-induced cell migration by targeting disabled homolog 2 in cervical carcinoma MicroRNA-130b promotes lung cancer progression via PPARγ/VEGF-A/BCL-2-mediated suppression of apoptosis MicroRNA-138 functions as a tumor suppressor in osteosarcoma by targeting differentiated embryonic chondrocyte gene 2 MicroRNA-155-3p promotes hepatocellular carcinoma formation by suppressing FBXW7 expression MicroRNA-19b-3p regulates nasopharyngeal carcinoma radiosensitivity by targeting TNFAIP3/NF-κB axis MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling MicroRNA-224 sustains Wnt/β-catenin signaling and promotes aggressive phenotype of colorectal cancer MicroRNA-361-3p suppresses tumor cell proliferation and metastasis by directly targeting SH2B1 in NSCLC MicroRNA-655-3p functions as a tumor suppressor by regulating ADAM10 and β-catenin pathway in Hepatocellular Carcinoma MicroRNAs in colorectal carcinoma - From pathogenesis to therapy Microarray-based identification of genes associated with cancer progression and prognosis in hepatocellular carcinoma Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4 Molecular targeted therapy for the treatment of gastric cancer Murine mesothelin: Characterization,expression,and inhibition of tumor growth in a murine model of pancreatic cancer N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells Nerve growth factor: role in growth,differentiation and controlling cancer cell development Nestin overexpression in hepatocellular carcinoma associates with epithelial-mesenchymal transition and chemoresistance Neuropilin-1 is associated with clinicopathology of gastric cancer and contributes to cell proliferation and migration as multifunctional co-receptors New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: An in vitro and in vivo study Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells - صفحه:1-13 Over-expression of long noncoding RNA BANCR inhibits malignant phenotypes of human bladder cancer Over-expression of the long non-coding RNA HOTTIP inhibits glioma cell growth by BRE - صفحه:1-15 Overexpression of CTNND1 in hepatocellular carcinoma promotes carcinous characters through activation of Wnt/β-catenin signaling Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma Oxidative stress in prostate hyperplasia and carcinogenesis PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition PIM-1 contributes to the malignancy of pancreatic cancer and displays diagnostic and prognostic value Pancreatic cancer cell-derived IGFBP-3 contributes to muscle wasting Pathologically decreased expression of MIR-193a contributes to metastasis by targeting WT1-E-cadherin axis in non-small cell lung cancers - صفحه:1-15 Patient-derived xenografts: A relevant preclinical model for drug development Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro Phosphatidylserine exposing-platelets and microparticles promote procoagulant activity in colon cancer patients Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer Protein phosphatase 2A-B55δ enhances chemotherapy sensitivity of human hepatocellular carcinoma under the regulation of microRNA-133b Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo RARγ-induced E-cadherin downregulation promotes hepatocellular carcinoma invasion and metastasis RNF8 promotes epithelial-mesenchymal transition of breast cancer cells Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells Reactivation of mutant p53 by capsaicin,the major constituent of peppers SYNJ2BP inhibits tumor growth and metastasis by activating DLL4 pathway in hepatocellular carcinoma Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate - صفحه:1-9 Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer - صفحه:1-11 Sirtuins in metabolism,DNA repair and cancer Spheres derived from the human SN12C renal cell carcinoma cell line are enriched in tumor initiating cells - صفحه:1-11 Subpopulation Treatment Effect Pattern Plot (STEPP) analysis of Ki67 assay according to histology: Prognostic relevance for resected early stage 'pure' and 'mixed' lobular breast cancer Sustained delivery of siRNA/PEI complex from in situ forming hydrogels potently inhibits the proliferation of gastric cancer Synthetic Bax-Anti Bcl2 combination module actuated by super artificial hTERT promoter selectively inhibits malignant phenotypes of bladder cancer Synthetic tetracycline-controllable shRNA targeting long non-coding RNA HOXD-AS1 inhibits the progression of bladder cancer TET3 inhibits TGF-β1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways TRIM11 overexpression promotes proliferation,migration and invasion of lung cancer cells Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model Targeting autophagy to sensitive glioma to temozolomide treatment Targeting interleukin-1 receptor-associated kinase 1 for human hepatocellular carcinoma Targeting microRNAs as key modulators of tumor immune response Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast The comparison of clinical and biological characteristics between IDH1 and IDH2 mutations in gliomas The human RNA surveillance factor UPF1 regulates tumorigenesis by targeting Smad7 in hepatocellular carcinoma The leukemogenic fusion gene MLL-AF9 alters microRNA expression pattern and inhibits monoblastic differentiation via MIR-511 repression The leukemogenic fusion gene MLL-AF9 alters microRNA expression pattern and inhibits monoblastic differentiation via miR-511 repression - صفحه:9- The role of the AMOP domain in MUC4/Y-promoted tumour angiogenesis and metastasis in pancreatic cancer Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients Trends and advances in tumor immunology and lung cancer immunotherapy - صفحه:1-13 Tripartite motif containing 62 is a novel prognostic marker and suppresses tumor metastasis via c-Jun/Slug signaling-mediated epithelial-mesenchymal transition in cervical cancer - صفحه:1-20 Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma Tumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8+ T cells during vaccine immunotherapy UHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomy Up-regulation of long non-coding RNA PANDAR is associated with poor prognosis and promotes tumorigenesis in bladder cancer - صفحه:1-10 Upregulation of miR-501-5p activates the wnt/β-catenin signaling pathway and enhances stem cell-like phenotype in gastric cancer - صفحه:1-9 Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: The rationale for their inclusion in the clinic WNT5A signaling impairs breast cancer cell migration and invasion via mechanisms independent of the epithelial-mesenchymal transition YPEL3 suppresses epithelial-mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt/β-catenin signaling pathway Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2,OCT4,BMI1) and clinical implication miR-589-5p inhibits MAP3K8 and suppresses CD90+ cancer stem cells in hepatocellular carcinoma - صفحه:1-12 srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer - صفحه:1-10 srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer - صفحه:191- β-arrestin1 at the cross-road of endothelin-1 signaling in cancer