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Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma
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نویسنده
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hu y. ,he m.-y. ,zhu l.-f. ,yang c.-c. ,zhou m.-l. ,wang q. ,zhang w. ,zheng y.-y. ,wang d.-m. ,xu z.-q. ,wu y.-n. ,liu l.-k.
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منبع
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journal of experimental and clinical cancer research - 2016 - دوره : 35 - شماره : 1
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چکیده
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Background: both tumor-associated macrophages (tams) and the epithelial to mesenchymal transition (emt) of cancer cells play key roles in promoting tumor progression. however,whether tams could induce emt in the progression of oral squamous cell carcinoma (oscc) remains undefined. results: here we detected the expression of macrophages markers cd68 and cd163,epithelial marker e-cadherin and mesenchymal marker vimentin in 127 oscc patients by using semi-quantitative immunohistochemistry. cd68 and cd163 expression was not confined to the infiltrating tams,but also detected in cancer cells. the high number of cd68-positive macrophages was correlated with poor overall survival. meanwhile,the expression of cd163 both in macrophages and in cancer cells was associated with poor overall survival and had a significant prognostic impact in oscc. importantly,the expression of cd163 in cancer cells had a significant relationship with e-cadherin and vimentin. furthermore,the incubation of tams conditioned medium resulted in a fibroblast-like appearance of cancer cells (hn4,hn6 and scc9) together with the decreased/increased expression of e-cadherin/ vimentin,which were correlated with the enhanced ability of migration and invasion. conclusions: our results indicate that tams could promote the emt of cancer cells,thereby leading to the progression of oral cancer. © 2016 hu et al.
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کلیدواژه
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CD163; CD68; Epithelial to mesenchymal transition; Oral squamous cell carcinoma; Tumor-associated macrophages
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آدرس
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jiangsu key laboratory of oral diseases,nanjing medical university,nanjing,china,department of oral and maxillofacial surgery,affiliated hospital of stomatology,nanjing medical university,postal#210029 136# hanzhong road,nanjing,jiangsu,china,department of stomatology,suzhou kowloon hospital,shanghai jiaotong university medical school,suzhou, China, jiangsu key laboratory of oral diseases,nanjing medical university,nanjing,china,department of basic science of stomatology,affiliated hospital of stomatology,nanjing medical university,postal#210029 136# hanzhong road,nanjing,jiangsu, China, department of stomatology,first affiliated hospital of soochow university,suzhou, China, jiangsu key laboratory of oral diseases,nanjing medical university,nanjing,china,department of basic science of stomatology,affiliated hospital of stomatology,nanjing medical university,postal#210029 136# hanzhong road,nanjing,jiangsu, China, jiangsu key laboratory of oral diseases,nanjing medical university,nanjing,china,department of basic science of stomatology,affiliated hospital of stomatology,nanjing medical university,postal#210029 136# hanzhong road,nanjing,jiangsu, China, jiangsu key laboratory of oral diseases,nanjing medical university,nanjing,china,department of basic science of stomatology,affiliated hospital of stomatology,nanjing medical university,postal#210029 136# hanzhong road,nanjing,jiangsu, China, jiangsu key laboratory of oral diseases,nanjing medical university,nanjing,china,department of basic science of stomatology,affiliated hospital of stomatology,nanjing medical university,postal#210029 136# hanzhong road,nanjing,jiangsu, China, jiangsu key laboratory of oral diseases,nanjing medical university,nanjing,china,department of basic science of stomatology,affiliated hospital of stomatology,nanjing medical university,postal#210029 136# hanzhong road,nanjing,jiangsu, China, jiangsu key laboratory of oral diseases,nanjing medical university,nanjing,china,department of oral and maxillofacial surgery,affiliated hospital of stomatology,nanjing medical university,postal#210029 136# hanzhong road,nanjing,jiangsu, China, jiangsu key laboratory of oral diseases,nanjing medical university,nanjing,china,department of oral and maxillofacial surgery,affiliated hospital of stomatology,nanjing medical university,postal#210029 136# hanzhong road,nanjing,jiangsu, China, jiangsu key laboratory of oral diseases,nanjing medical university,nanjing,china,department of oral and maxillofacial surgery,affiliated hospital of stomatology,nanjing medical university,postal#210029 136# hanzhong road,nanjing,jiangsu, China, jiangsu key laboratory of oral diseases,nanjing medical university,nanjing,china,department of basic science of stomatology,affiliated hospital of stomatology,nanjing medical university,postal#210029 136# hanzhong road,nanjing,jiangsu, China
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Authors
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