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Sirtuins in metabolism,DNA repair and cancer
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نویسنده
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mei z. ,zhang x. ,yi j. ,huang j. ,he j. ,tao y.
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منبع
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journal of experimental and clinical cancer research - 2016 - دوره : 35 - شماره : 1
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چکیده
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The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. they have involved in diverse cellular processes including dna repair,energy metabolism,and tumorigenesis. notably,genomic instability and metabolic reprogramming are two of characteristic hallmarks in cancer. in this review,we summarize current knowledge on the functions of sirtuins mainly regarding dna repair and energy metabolism,and further discuss the implication of sirtuins in cancer specifically by regulating genome integrity and cancer-related metabolism. © 2016 the author(s).
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کلیدواژه
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Cancer; DNA damage; Metabolism; Post-translation modification; Sirtuin
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آدرس
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key laboratory of carcinogenesis and cancer invasion,ministry of education,xiangya hospital,central south university,87 xiangya road,changsha,hunan,410008,china,cancer research institute,school of basic medicine,central south university,changsha,hunan,410078, China, key laboratory of carcinogenesis and cancer invasion,ministry of education,xiangya hospital,central south university,87 xiangya road,changsha,hunan,410008,china,cancer research institute,school of basic medicine,central south university,changsha,hunan,410078, China, key laboratory of carcinogenesis and cancer invasion,ministry of education,xiangya hospital,central south university,87 xiangya road,changsha,hunan,410008,china,cancer research institute,school of basic medicine,central south university,changsha,hunan,410078, China, key laboratory of carcinogenesis and cancer invasion,ministry of education,xiangya hospital,central south university,87 xiangya road,changsha,hunan,410008,china,cancer research institute,school of basic medicine,central south university,changsha,hunan,410078, China, key laboratory of carcinogenesis and cancer invasion,ministry of education,xiangya hospital,central south university,87 xiangya road,changsha,hunan,410008,china,cancer research institute,school of basic medicine,central south university,changsha,hunan,410078, China, key laboratory of carcinogenesis and cancer invasion,ministry of education,xiangya hospital,central south university,87 xiangya road,changsha,hunan,410008,china,cancer research institute,school of basic medicine,central south university,changsha,hunan,410078, China
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Authors
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