plos genetics سال:2016 - دوره:12

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plos genetics
سال:2016 - دوره:12 - شماره:4

A Cohesin-Based Partitioning Mechanism Revealed upon Transcriptional Inactivation of Centromere A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects A Hox Transcription Factor Collective Binds a Highly Conserved Distal-less cis-Regulatory Module to Generate Robust Transcriptional Outcomes Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus An Arabidopsis SUMO E3 Ligase,SIZ1,Negatively Regulates Photomorphogenesis by Promoting COP1 Activity An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variation and Local Adaptation in Drosophila melanogaster An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes Arabidopsis thaliana DM2h (R8) within the Landsberg RPP1-like Resistance Locus Underlies Three Different Cases of EDS1-Conditioned Autoimmunity BRR2a Affects Flowering Time via FLC Splicing Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition Chromosomal-Level Assembly of the Asian Seabass Genome Using Long Sequence Reads and Multi-layered Scaffolding Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling Cooperative Wnt-Nodal Signals Regulate the Patterning of Anterior Neuroectoderm De Novo Centromere Formation and Centromeric Sequence Expansion in Wheat and its Wide Hybrids De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability,Replication Impairment and Telomere Shortening FgPrp4 Kinase Is Important for Spliceosome B-Complex Activation and Splicing Efficiency in Fusarium graminearum Functional Regression Models for Epistasis Analysis of Multiple Quantitative Traits Genetic Dissection of Dual Roles for the Transcription Factor six7 in Photoreceptor Development and Patterning in Zebrafish Genetic Manipulation of Glycogen Allocation Affects Replicative Lifespan in E. coli Genome-Wide Mapping Targets of the Metazoan Chromatin Remodeling Factor NURF Reveals Nucleosome Remodeling at Enhancers,Core Promoters and Gene Insulators Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer Gifsy-1 Prophage IsrK with Dual Function as Small and Messenger RNA Modulates Vital Bacterial Machineries Hybrid Sterility Locus on Chromosome X Controls Meiotic Recombination Rate in Mouse Integrative Tissue-Specific Functional Annotations in the Human Genome Provide Novel Insights on Many Complex Traits and Improve Signal Prioritization in Genome Wide Association Studies Intermittent Stem Cell Cycling Balances Self-Renewal and Senescence of the C. elegans Germ Line Joint Estimation of Contamination,Error and Demography for Nuclear DNA from Ancient Humans Maternal Setdb1 Is Required for Meiotic Progression and Preimplantation Development in Mouse Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells Palmitoylation of the Cysteine Residue in the DHHC Motif of a Palmitoyl Transferase Mediates Ca2+ Homeostasis in Aspergillus Role of Double-Strand Break End-Tethering during Gene Conversion in Saccharomyces cerevisiae Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation Separase Is Required for Homolog and Sister Disjunction during Drosophila melanogaster Male Meiosis,but Not for Biorientation of Sister Centromeres Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila Splicing-Mediated Autoregulation Modulates Rpl22p Expression in Saccharomyces cerevisiae Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions Survival of the Curviest: Noise-Driven Selection for Synergistic Epistasis The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster The Increasing Importance of Gene-Based Analyses The MADD-3 LAMMER Kinase Interacts with a p38 MAP Kinase Pathway to Regulate the Display of the EVA-1 Guidance Receptor in Caenorhabditis elegans The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization What Is the Tree of Life? ZmMADS47 Regulates Zein Gene Transcription through Interaction with Opaque2 shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation,Secretion and Toxicity