plos genetics سال:2016 - دوره:12

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plos genetics
سال:2016 - دوره:12 - شماره:5

A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive A Genetic Screen Identifies a Requirement for Cysteine-Rich–Receptor-Like Kinases in Rice NH1 (OsNPR1)-Mediated Immunity A Maternal System Initiating the Zygotic Developmental Program through Combinatorial Repression in the Ascidian Embryo A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus A Mouse Model for Conditional Secretion of Specific Single-Chain Antibodies Provides Genetic Evidence for Regulation of Cortical Plasticity by a Non-cell Autonomous Homeoprotein Transcription Factor A Novel Mutant Allele of Pw1/Peg3 Does Not Affect Maternal Behavior or Nursing Behavior A Ploidy-Sensitive Mechanism Regulates Aperture Formation on the Arabidopsis Pollen Surface and Guides Localization of the Aperture Factor INP1 A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes Additive Expression of Consolidated Memory through Drosophila Mushroom Body Subsets An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure,Neural Crest Specification and Anterior-Posterior Axis Extension Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila Animal Models Are Valid to Uncover Disease Mechanisms Antimicrobial Functions of Lactoferrin Promote Genetic Conflicts in Ancient Primates and Modern Humans Arabidopsis AtMORC4 and AtMORC7 Form Nuclear Bodies and Repress a Large Number of Protein-Coding Genes BOD1 Is Required for Cognitive Function in Humans and Drosophila Bayesian Inference of Reticulate Phylogenies under the Multispecies Network Coalescent Characterization of Expression Quantitative Trait Loci in Pedigrees from Colombia and Costa Rica Ascertained for Bipolar Disorder Chloroplast RNA-Binding Protein RBD1 Promotes Chilling Tolerance through 23S rRNA Processing in Arabidopsis Chromatoid Body Protein TDRD6 Supports Long 3’ UTR Triggered Nonsense Mediated mRNA Decay Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States Comparative Genomic Analysis of Drechmeria coniospora Reveals Core and Specific Genetic Requirements for Fungal Endoparasitism of Nematodes DNA Sequence Evolution and Rare Homoeologous Conversion in Tetraploid Cotton Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet Enhancement of Transcription by a Splicing-Competent Intron Is Dependent on Promoter Directionality Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells Exploiting Genetic Interference for Antiviral Therapy Fission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking Genome-Wide Analysis Identifies Germ-Line Risk Factors Associated with Canine Mammary Tumours Genomic Imprinting: A New Epigenetic Perspective of Sleep Regulation Germline Defects Caused by Smed-boule RNA-Interference Reveal That Egg Capsule Deposition Occurs Independently of Fertilization,Ovulation,Mating,or the Presence of Gametes in Planarian Flatworms Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion High-Resolution Mapping of Crossover and Non-crossover Recombination Events by Whole-Genome Re-sequencing of an Avian Pedigree Hypothalamic Leptin Resistance: From BBB to BBSome Identification of a Functional Risk Variant for Pemphigus Vulgaris in the ST18 Gene Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein Long-Range Chromosome Interactions Mediated by Cohesin Shape Circadian Gene Expression Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling Mapping Topoisomerase IV Binding and Activity Sites on the E. coli Genome Mitochondrial Polyadenylation Is a One-Step Process Required for mRNA Integrity and tRNA Maturation Molecular Basis and Therapeutic Strategies to Rescue Factor IX Variants That Affect Splicing and Protein Function Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey,van den Ende-Gupta,and Raine Syndromes N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy NPR-9,a Galanin-Like G-Protein Coupled Receptor,and GLR-1 Regulate Interneuronal Circuitry Underlying Multisensory Integration of Environmental Cues in Caenorhabditis elegans Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ PABPN1-Dependent mRNA Processing Induces Muscle Wasting Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders Predicting Ancestral Segmentation Phenotypes from Drosophila to Anopheles Using In Silico Evolution Recombination-Independent Recognition of DNA Homology for Repeat-Induced Point Mutation (RIP) Is Modulated by the Underlying Nucleotide Sequence Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila Selective Retention of an Inactive Allele of the DKK2 Tumor Suppressor Gene in Hepatocellular Carcinoma Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress Spermatogenesis Studies Reveal a Distinct Nonsense-Mediated mRNA Decay (NMD) Mechanism for mRNAs with Long 3′UTRs Testing Rare-Variant Association without Calling Genotypes Allows for Systematic Differences in Sequencing between Cases and Controls The AP-2 Transcription Factor APTF-2 Is Required for Neuroblast and Epidermal Morphogenesis in Caenorhabditis elegans Embryogenesis The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins,Translation Elongation Factors and Histones The Contribution of GWAS Loci in Familial Dyslipidemias The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function The Gene Expression Program for the Formation of Wing Cuticle in Drosophila The Genomic Basis of Evolutionary Innovation in Pseudomonas aeruginosa The Great Migration and African-American Genomic Diversity The Hybrid Histidine Kinase LadS Forms a Multicomponent Signal Transduction System with the GacS/GacA Two-Component System in Pseudomonas aeruginosa The Occurrence of the Holometabolous Pupal Stage Requires the Interaction between E93,Krüppel-Homolog 1 and Broad-Complex The Pilin N-terminal Domain Maintains Neisseria gonorrhoeae Transformation Competence during Pilus Phase Variation The Splicing Efficiency of Activating HRAS Mutations Can Determine Costello Syndrome Phenotype and Frequency in Cancer Two Components of the RNA-Directed DNA Methylation Pathway Associate with MORC6 and Silence Loci Targeted by MORC6 in Arabidopsis UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts Ubr3,a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development—Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga