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The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins,Translation Elongation Factors and Histones
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نویسنده
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truttmann m.c. ,cruz v.e. ,guo x. ,engert c. ,schwartz t.u. ,ploegh h.l.
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منبع
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plos genetics - 2016 - دوره : 12 - شماره : 5
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چکیده
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Protein ampylation by fic domain-containing proteins (fic proteins) is an ancient and conserved post-translational modification of mostly unexplored significance. here we characterize the caenorhabditis elegans fic protein fic-1 in vitro and in vivo. fic-1 is an ampylase that localizes to the nuclear surface and modifies core histones h2 and h3 as well as heat shock protein 70 family members and translation elongation factors. the three-dimensional structure of fic-1 is similar to that of its human ortholog,hype,with 38% sequence identity. we identify a link between fic-1-mediated ampylation and susceptibility to the pathogen pseudomonas aeruginosa,establishing a connection between ampylation and innate immunity in c. elegans. © 2016 truttmann et al.
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آدرس
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whitehead institute for biomedical research,cambridge,ma, United States, department of biology,massachusetts institute of technology (mit),cambridge,ma, United States, department of biology,massachusetts institute of technology (mit),cambridge,ma, United States, department of biology,massachusetts institute of technology (mit),cambridge,ma, United States, department of biology,massachusetts institute of technology (mit),cambridge,ma, United States, whitehead institute for biomedical research,cambridge,ma,united states,department of biology,massachusetts institute of technology (mit),cambridge,ma, United States
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Authors
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