plos genetics سال:2017 - دوره:13

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plos genetics
سال:2017 - دوره:13 - شماره:3

A de novo variant in the ASPRV1 gene in a dog with ichthyosis A genetic switch controls the production of flagella and toxins in Clostridium difficile A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy Adaptation of A-to-I RNA editing in Drosophila An SMC-like protein binds and regulates Caenorhabditis elegans condensins Analysis of large versus small dogs reveals three genes on the canine X chromosome associated with body weight,muscling and back fat thickness Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease CLAVATA1 controls distinct signaling outputs that buffer shoot stem cell proliferation through a two-step transcriptional compensation loop COLEC10 is mutated in 3MC patients and regulates early craniofacial development CSL encodes a leucine-rich-repeat protein implicated in red/violet light signaling to the circadian clock in Chlamydomonas CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases Correction to: Telomerase Is Required for Zebrafish Lifespan (PLoS Genetics,(2013),9,1,(e1003214),10.1371/journal.pgen.1003214) Correction to: Transcriptional Orchestration of the Global Cellular Response of a Model Pennate Diatom to Diel Light Cycling under Iron Limitation (PLOS Genetics,(2016),12,12,(e1006490),10.1371/journal.pgen.1006490) DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy Depletion of Arabidopsis SC35 and SC35-like serine/arginine-rich proteins affects the transcription and splicing of a subset of genes Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition Evolved genetic and phenotypic differences due to mitochondrial-nuclear interactions Excess of genomic defects in a woolly mammoth on Wrangel island Fast growth conditions uncouple the final stages of chromosome segregation and cell division in Escherichia coli Fishing for adaptive epistasis using mitonuclear interactions Functional classification of DNA variants by hybrid minigenes: Identification of 30 spliceogenic variants of BRCA2 exons 17 and 18 Global analysis of translation termination in E. coli Independent introductions and admixtures have contributed to adaptation of European maize and its American counterparts Inferring fitness landscapes and selection on phenotypic states from single-cell genealogical data Integrating molecular QTL data into genome-wide genetic association analysis: Probabilistic assessment of enrichment and colocalization Investigating the case of human nose shape and climate adaptation Meiotic recombination modulates the structure and dynamics of the synaptonemal complex during C. elegans meiosis Mutations in mitochondrial DNA causing tubulointerstitial kidney disease Overexpression of the WOX gene STENOFOLIA improves biomass yield and sugar release in transgenic grasses and display altered cytokinin homeostasis Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies PLOS Genetics 2016 Reviewer and Editorial Board Thank You Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+versus CD8+T cells Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression SEPT12 phosphorylation results in loss of the septin ring/sperm annulus,defective sperm motility and poor male fertility SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer Salmonella genomic island 1 (SGI1) reshapes the mating apparatus of IncC conjugative plasmids to promote self-propagation Shared regulatory sites are abundant in the human genome and shed light on genome evolution and disease pleiotropy TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF The social genome: Current findings and implications for the study of human genetics The transjugation machinery of Thermus thermophilus: Identification of TdtA,an ATPase involved in DNA donation Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex Visualizing the structure of RNA-seq expression data using grade of membership models Whole-genome analysis of papillary kidney cancer finds significant noncoding alterations Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus dMyc is required in retinal progenitors to prevent JNK-mediated retinal glial activation hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer