plos genetics سال:2017 - دوره:13

Fa | Ar | En


plos genetics
سال:2017 - دوره:13 - شماره:4

A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism,with implications for human and animal health Correction to: A Year of Infection in the Intensive Care Unit: Prospective Whole Genome Sequencing of Bacterial Clinical Isolates Reveals Cryptic Transmissions and Novel Microbiota (PLOS Genetics,(2015),11,7,(e1005413),10.1371/journal.pgen.1005413) Correction to: Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality (PLOS Genetics,(2015),11,7,(e1005310),10.1371/journal.pgen.1005310) Correction to: Gifsy-1 Prophage IsrK with Dual Function as Small and Messenger RNA Modulates Vital Bacterial Machineries (PLOS Genetics,(2016),12,4,(e1005975),10.1371/journal.pgen.1005975) Correction to: Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas (PLOS Genetics,(2017),13,2,(e1006546),10.1371/journal.pgen.1006546) Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African ancestry anthropometry genetics consortium Disrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [PSI+] prion formation Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci Evolutionary history of Tibetans inferred from whole-genome sequencing Fetal de novo mutations and preterm birth GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states Gene co-expression network connectivity is an important determinant of selective constraint Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation Joint genetic analysis using variant sets reveals polygenic gene-context interactions Larval crowding accelerates C. elegans development and reduces lifespan Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease Meioc maintains an extended meiotic prophase I in mice Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions Natural variation of piRNA expression affects immunity to transposable elements Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene Novel insights into SLC25A46-related pathologies in a genetic mouse model Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments Phenome-wide heritability analysis of the UK Biobank Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations Probing the canonicity of the Wnt/Wingless signaling pathway Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip Retraction to: Loss of a Conserved tRNA Anticodon Modification Perturbs Plant Immunity (PLOS Genetics,(2015),11,10,(e1005586),10.1371/journal.pgen.1005586) Semaphorin-1a prevents Drosophila olfactory projection neuron dendrites from mis-targeting into select antennal lobe regions Structured mating: Patterns and implications TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone The ESCRT regulator Did2 maintains the balance between long-distance endosomal transport and endocytic trafficking The SnRK2 kinases modulate miRNA accumulation in Arabidopsis The Zic family homologue Odd-paired regulates Alk expression in Drosophila The bHLH transcription factor SPATULA enables cytokinin signaling,and both activate auxin biosynthesis and transport genes at the medial domain of the gynoecium The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples The time and place of European admixture in Ashkenazi Jewish history Three distinct mechanisms of long-distance modulation of gene expression in yeast Tissue-specific enhancer repression through molecular integration of cell signaling inputs Transcriptional repression of frequency by the IEC-1-INO80 complex is required for normal Neurospora circadian clock function Triplin,a small molecule,reveals copper ion transport in ethylene signaling from ATX1 to RAN1 Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice VAMP3/Syb and YKT6 are required for the fusion of constitutive secretory carriers with the plasma membrane WDR23 regulates NRF2 independently of KEAP1 What is adaptation by natural selection? Perspectives of an experimental microbiologist Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila