plos genetics سال:2017 - دوره:13

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plos genetics
سال:2017 - دوره:13 - شماره:8

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds Adaptive introgression from distant Caribbean islands contributed to the diversification of a microendemic adaptive radiation of trophic specialist pupfishes Analysis of 62 hybrid assembled human Y chromosomes exposes rapid structural changes and high rates of gene conversion CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries Composite likelihood method for inferring local pedigrees Comprehensive analysis of nucleocytoplasmic dynamics of mRNA in Drosophila cells Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate Culture-induced recurrent epigenetic aberrations in human pluripotent stem cells Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation Deconstructing isolation-by-distance: The genomic consequences of limited dispersal Defining the genetic susceptibility to cervical neoplasia—A genome-wide association study Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases Fruit weight is controlled by Cell Size Regulator encoding a novel protein that is expressed in maturing tomato fruits Functional significance of rare neuroligin 1 variants found in autism Genetic analysis of the Candida albicans biofilm transcription factor network using simple and complex haploinsufficiency HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity - صفحه:e1006984- Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy? Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO2sensing and hyphal development in Candida albicans Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH) Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus MicroRNA-275 targets sarco/endoplasmic reticulum Ca2+adenosine triphosphatase (SERCA) to control key functions in the mosquito gut Northeast African genomic variation shaped by the continuity of indigenous groups and Eurasian migrations Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma PKA activity is essential for relieving the suppression of hyphal growth and appressorium formation by MoSfl1 in Magnaporthe oryzae PRRG4 function reveals that Robo trafficking is evolutionarily conserved Plant microRNAs in larval food regulate honeybee caste development Positional cloning of quantitative trait nucleotides for blood pressure and cardiac QT-interval by targeted CRISPR/Cas9 editing of a novel long non-coding RNA Rare coding variants pinpoint genes that control human hematological traits Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries Replication fork slowing and stalling are distinct,checkpoint-independent consequences of replicating damaged DNA SCFAtPP2-B11modulates ABA signaling by facilitating SnRK2.3 degradation in Arabidopsis thaliana The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene The activation of OsEIL1 on YUC8M transcription and auxin biosynthesis is required for ethylene-inhibited root elongation in rice early seedling development Tissue-specific insulin signaling mediates female sexual attractiveness Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast Variation of the meiotic recombination landscape and properties over a broad evolutionary distance in yeasts Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression mlh3 mutations in baker’s yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide rahu is a mutant allele of Dnmt3c,encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline β-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice