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Defining the genetic susceptibility to cervical neoplasia—A genome-wide association study
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نویسنده
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leo p.j. ,madeleine m.m. ,wang s. ,schwartz s.m. ,newell f. ,pettersson-kymmer u. ,hemminki k. ,hallmans g. ,tiews s. ,steinberg w. ,rader j.s. ,castro f. ,safaeian m. ,franco e.l. ,coutlée f. ,ohlsson c. ,cortes a. ,marshall m. ,mukhopadhyay p. ,cremin k. ,johnson l.g. ,garland s. ,tabrizi s.n. ,wentzensen n. ,sitas f. ,little j. ,cruickshank m. ,frazer i.h. ,hildesheim a. ,brown m.a.
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منبع
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plos genetics - 2017 - دوره : 13 - شماره : 8
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چکیده
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A small percentage of women with cervical hpv infection progress to cervical neoplasia,and the risk factors determining progression are incompletely understood. we sought to define the genetic loci involved in cervical neoplasia and to assess its heritability using unbiased unrelated case/control statistical approaches. we demonstrated strong association of cervical neoplasia with risk and protective hla haplotypes that are determined by the amino-acids carried at positions 13 and 71 in pocket 4 of hla-drb1 and position 156 in hla-b. furthermore,36% (standard error 2.4%) of liability of hpv-associated cervical pre-cancer and cancer is determined by common genetic variants. women in the highest 10% of genetic risk scores have approximately >7.1% risk,and those in the highest 5% have approximately >21.6% risk,of developing cervical neoplasia. future studies should examine genetic risk prediction in assessing the risk of cervical neoplasia further,in combination with other screening methods. © 2017 leo et al.
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آدرس
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institute of health and biomedical innovation,queensland university of technology,translational research institute,princess alexandra hospital,woolloongabba, Australia, program in epidemiology,fred hutchinson cancer research center,seattle,wa, United States, department of population sciences,beckman research institute,city of hope,duarte,ca, United States, program in epidemiology,fred hutchinson cancer research center,seattle,wa, United States, institute of health and biomedical innovation,queensland university of technology,translational research institute,princess alexandra hospital,woolloongabba, Australia, department of pharmacology and clinical neuroscience,umeå university,umeå,sweden,department of public health and clinical medicine,umeå university,umeå, Sweden, division of molecular genetic epidemiology,german cancer research center (dkfz),heidelberg,germany,center for primary health care research,lund university,lund, Sweden, nutritional research,department of public health and clinical medicine,umeå university,umeå, Sweden, mhc laboratory for cytopathology,dr.steinberg gmbh,soest, Germany, mhc laboratory for cytopathology,dr.steinberg gmbh,soest, Germany, department of obstetrics and gynecology,medical college of wisconsin,milwaukee,wi, United States, division of clinical epidemiology and aging research,german cancer research center (dkfz),heidelberg, Germany, division of cancer epidemiology and genetics,national cancer institute,bethesda,md, United States, division of cancer epidemiology,mcgill university,montreal,qc, Canada, département de microbiologie,infectiologie et immunologie,université de montréal,montréal,qc, Canada, internal medicine and clinical nutrition,institute of medicine,sahlgrenska academy university of gothenburg,gothenburg,sweden,centre for bone and arthritis research,institute of medicine,sahlgrenska academy,university of gothenburg,gothenburg, Sweden, institute of health and biomedical innovation,queensland university of technology,translational research institute,princess alexandra hospital,woolloongabba, Australia, institute of health and biomedical innovation,queensland university of technology,translational research institute,princess alexandra hospital,woolloongabba, Australia, institute of health and biomedical innovation,queensland university of technology,translational research institute,princess alexandra hospital,woolloongabba, Australia, institute of health and biomedical innovation,queensland university of technology,translational research institute,princess alexandra hospital,woolloongabba, Australia, program in epidemiology,fred hutchinson cancer research center,seattle,wa, United States, regional world health organisation human papillomavirus laboratory network,department of microbiology and infectious diseases,the royal women’s hospital,parkville,vic 3052,australia,department of obstetrics and gynaecology,university of melbourne,murdoch childrens research institute,the royal children’s hospital,parkville,vic 3052, Australia, department of obstetrics and gynaecology,university of melbourne,murdoch childrens research institute,the royal children’s hospital,parkville,vic 3052, Australia, division of cancer epidemiology and genetics,national cancer institute,bethesda,md, United States, cancer council nsw,sydney,nsw,australia,sydney school of public health,university of sydney,camperdown,nsw,australia,school of public health and community medicine,university of new south wales,kensington,nsw, Australia, school of epidemiology,public health and preventive medicine,faculty of medicine,university of ottawa,ottawa, Canada, division of medical education,university of aberdeen,aberdeen, United Kingdom, faculty of medicine and biomedical sciences,university of queensland,translational research institute,princess alexandra hospital,woolloongabba,qld 4102, Australia, division of cancer epidemiology and genetics,national cancer institute,bethesda,md, United States, institute of health and biomedical innovation,queensland university of technology,translational research institute,princess alexandra hospital,woolloongabba, Australia
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Authors
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