plos genetics سال:2014 - دوره:10

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plos genetics
سال:2014 - دوره:10 - شماره:5

A Dominant-Negative Mutation of Mouse Lmx1b Causes Glaucoma and Is Semi-lethal via LBD1-Mediated Dimerisation A Genome-Wide Assessment of the Role of Untagged Copy Number Variants in Type 1 Diabetes A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum A Lack of Parasitic Reduction in the Obligate Parasitic Green Alga Helicosporidium A Mutation in the FAM83G Gene in Dogs with Hereditary Footpad Hyperkeratosis (HFH) A Novel C2H2 Transcription Factor that Regulates gliA Expression Interdependently with GliZ in Aspergillus fumigatus Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish Allele-Specific Genome-wide Profiling in Human Primary Erythroblasts Reveal Replication Program Organization Allelic Expression of Deleterious Protein-Coding Variants across Human Tissues An In Vivo EGF Receptor Localization Screen in C. elegans Identifies the Ezrin Homolog ERM-1 as a Temporal Regulator of Signaling Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics Biased,Non-equivalent Gene-Proximal and -Distal Binding Motifs of Orphan Nuclear Receptor TR4 in Primary Human Erythroid Cells Copy Number Variation Is a Fundamental Aspect of the Placental Genome Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma Drosha Promotes Splicing of a Pre-microRNA-like Alternative Exon Drosophila melanogaster Hox Transcription Factors Access the RNA Polymerase II Machinery through Direct Homeodomain Binding to a Conserved Motif of Mediator Subunit Med19 EDR1 Physically Interacts with MKK4/MKK5 and Negatively Regulates a MAP Kinase Cascade to Modulate Plant Innate Immunity Enhanced Interaction between Pseudokinase and Kinase Domains in Gcn2 stimulates eIF2α Phosphorylation in Starved Cells Epistatically Interacting Substitutions Are Enriched during Adaptive Protein Evolution Extensive Diversity of Prion Strains Is Defined by Differential Chaperone Interactions and Distinct Amyloidogenic Regions Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2 GOLPH3 Is Essential for Contractile Ring Formation and Rab11 Localization to the Cleavage Site during Cytokinesis in Drosophila melanogaster Genes That Bias Mendelian Segregation Genetic Dissection of the Drosophila melanogaster Female Head Transcriptome Reveals Widespread Allelic Heterogeneity Genetic Interactions Involving Five or More Genes Contribute to a Complex Trait in Yeast Genome Sequencing and Comparative Genomics of the Broad Host-Range Pathogen Rhizoctonia solani AG8 Genome-Wide Inference of Ancestral Recombination Graphs Genome-Wide Nucleosome Positioning Is Orchestrated by Genomic Regions Associated with DNase I Hypersensitivity in Rice G×G×E for Lifespan in Drosophila: Mitochondrial,Nuclear,and Dietary Interactions that Modify Longevity Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans Heterogeneity in the Frequency and Characteristics of Homologous Recombination in Pneumococcal Evolution Hyperactivated Wnt Signaling Induces Synthetic Lethal Interaction with Rb Inactivation by Elevating TORC1 Activities Insights into the Genetic Structure and Diversity of 38 South Asian Indians from Deep Whole-Genome Sequencing Intron Retention in the 5′UTR of the Novel ZIF2 Transporter Enhances Translation to Promote Zinc Tolerance in Arabidopsis Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification Loss of Function Mutation in the Palmitoyl-Transferase HHAT Leads to Syndromic 46,XY Disorder of Sex Development by Impeding Hedgehog Protein Palmitoylation and Signaling Meiotic Drive Impacts Expression and Evolution of X-Linked Genes in Stalk-Eyed Flies Mlh2 Is an Accessory Factor for DNA Mismatch Repair in Saccharomyces cerevisiae More of a Good Thing or Less of a Bad Thing: Gene Copy Number Variation in Polyploid Cells of the Placenta Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder Mutations in Four Glycosyl Hydrolases Reveal a Highly Coordinated Pathway for Rhodopsin Biosynthesis and N-Glycan Trimming in Drosophila melanogaster Mutations in the Cholesterol Transporter Gene ABCA5 Are Associated with Excessive Hair Overgrowth Null Mutation in PGAP1 Impairing Gpi-Anchor Maturation in Patients with Intellectual Disability and Encephalopathy Octopamine Neuromodulation Regulates Gr32a-Linked Aggression and Courtship Pathways in Drosophila Males PAX6 Regulates Melanogenesis in the Retinal Pigmented Epithelium through Feed-Forward Regulatory Interactions with MITF PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Embryonic Gene Expression Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease Phosphorylation of a WRKY Transcription Factor by MAPKs Is Required for Pollen Development and Function in Arabidopsis Population Genomic Analysis of Ancient and Modern Genomes Yields New Insights into the Genetic Ancestry of the Tyrolean Iceman and the Genetic Structure of Europe Predicting the Minimal Translation Apparatus: Lessons from the Reductive Evolution of Mollicutes R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome RPM-1 Uses Both Ubiquitin Ligase and Phosphatase-Based Mechanisms to Regulate DLK-1 during Neuronal Development Rapid Evolution of PARP Genes Suggests a Broad Role for ADP-Ribosylation in Host-Virus Conflicts Ras-Mediated Deregulation of the Circadian Clock in Cancer Recent Mitochondrial DNA Mutations Increase the Risk of Developing Common Late-Onset Human Diseases Retinoic Acid-Related Orphan Receptor γ (RORγ): A Novel Participant in the Diurnal Regulation of Hepatic Gluconeogenesis and Insulin Sensitivity Retinoid-X-Receptors (α/β) in Melanocytes Modulate Innate Immune Responses and Differentially Regulate Cell Survival following UV Irradiation Revertant Mutation Releases Confined Lethal Mutation,Opening Pandora's Box: A Novel Genetic Pathogenesis Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway SHP2 Regulates Chondrocyte Terminal Differentiation,Growth Plate Architecture and Skeletal Cell Fates Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland Selectivity in Genetic Association with Sub-classified Migraine in Women Single Nucleotide Variants in Transcription Factors Associate More Tightly with Phenotype than with Gene Expression Six Homeoproteins and a Iinc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype Spermatid Cyst Polarization in Drosophila Depends upon apkc and the CPEB Family Translational Regulator orb2 The Case for Junk DNA The Impact of Population Demography and Selection on the Genetic Architecture of Complex Traits The Impairment of MAGMAS Function in Human Is Responsible for a Severe Skeletal Dysplasia The Proper Splicing of RNAi Factors Is Critical for Pericentric Heterochromatin Assembly in Fission Yeast The Spatiotemporal Program of DNA Replication Is Associated with Specific Combinations of Chromatin Marks in Human Cells Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction dGTP Starvation in Escherichia coli Provides New Insights into the Thymineless-Death Phenomenon p53 Requires the Stress Sensor USF1 to Direct Appropriate Cell Fate Decision