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Six Homeoproteins and a Iinc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
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نویسنده
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sakakibara i. ,santolini m. ,ferry a. ,hakim v. ,pascal m.
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منبع
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plos genetics - 2014 - دوره : 10 - شماره : 5
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چکیده
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Thousands of long intergenic non-coding rnas (lincrnas) are encoded by the mammalian genome. however,the function of most of these lincrnas has not been identified in vivo. here,we demonstrate a role for a novel lincrna,linc-myh,in adult fast-type myofiber specialization. fast myosin heavy chain (myh) genes and linc-myh share a common enhancer,located in the fast myh gene locus and regulated by six1 homeoproteins. linc-myh in nuclei of fast-type myofibers prevents slow-type and enhances fast-type gene expression. functional fast-sarcomeric unit formation is achieved by the coordinate expression of fast myhs and linc-myh,under the control of a common six-bound enhancer. © 2014 sakakibara et al.
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آدرس
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inserm u1016,institut cochin,paris,france,cnrs umr 8104,paris,france,université paris descartes,sorbonne paris cité,paris, France, laboratoire de physique statistique,cnrs,université p. et m. curie,université d. diderot,école normale supérieure,paris, France, cnrs umr 8104,paris,france,université pierre et marie curie-paris 6,sorbonne universités,umr s794,inserm u974,cnrs umr7215,institut de myologie,paris, France, laboratoire de physique statistique,cnrs,université p. et m. curie,université d. diderot,école normale supérieure,paris, France, inserm u1016,institut cochin,paris,france,cnrs umr 8104,paris,france,université paris descartes,sorbonne paris cité,paris, France
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Authors
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