plos genetics سال:2012 - دوره:8

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plos genetics
سال:2012 - دوره:8 - شماره:2

A pathogenic mechanism in huntington's disease involves small CAG-repeated RNAs with neurotoxic activity A regulatory network for coordinated flower maturation A strong deletion bias in nonallelic gene conversion Association of a functional variant in the wnt co-receptor LRP6 with early onset ileal Crohn's Disease Cell lineage analysis of the mammalian female germline Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes Computational prediction and molecular characterization of an oomycete effector and the cognate arabidopsis resistance gene Contrasting properties of gene-specific regulatory,coding,and copy number mutations in saccharomyces cerevisiae: Frequency,effects,and dominance Developmental transcriptional networks are required to maintain neuronal subtype identity in the mature nervous system Diced triplets expose neurons to RISC Discovery of a modified tetrapolar sexual cycle in Cryptococcus amylolentus and the evolution of MAT in the Cryptococcus species complex Down-regulating sphingolipid synthesis increases yeast lifespan Evaluation of the role of functional constraints on the integrity of an ultraconserved region in the genus Drosophila Familial identification: Population structure and relationship distinguishability GTPase activity and neuronal toxicity of parkinson's disease-associated LRRK2 is regulated by ArfGAP1 Gene expression and stress response mediated by the epigenetic regulation of a transposable element small RNA Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations Genome-wide association study in East Asians identifies novel susceptibility loci for breast cancer Genomic restructuring in the tasmanian devil facial tumour: Chromosome painting and gene mapping provide clues to evolution of a transmissible tumour Inter-homolog crossing-over and synapsis in arabidopsis meiosis are dependent on the chromosome axis protein atasy3 Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint Loss of tgif function causes holoprosencephaly by disrupting the Shh signaling pathway Mixed effects modeling of proliferation rates in cell-based models: Consequence for pharmacogenomics and Cancer Msx homeobox genes critically regulate embryo implantation by controlling paracrine signaling between uterine stroma and epithelium Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis Neurophysiological defects and neuronal gene deregulation in drosophila mir-124 mutants Nondisjunction of a single chromosome leads to breakage and activation of DNA damage checkpoint in G2 Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis Positive selection for new disease mutations in the human germline: Evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B Psoriasis patients are enriched for genetic variants that protect against hiv-1 disease Raf1 is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome Repression of a potassium channel by nuclear hormone receptor and TGF-β signaling modulates insulin signaling in Caenorhabditis elegans Rewiring of PDZ domain-ligand interaction network contributed to eukaryotic evolution Sequestration of highly expressed mrnas in cytoplasmic granules,p-bodies,and stress granules enhances cell viability Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1 Systematic detection of epistatic interactions based on allele pair frequencies The caenorhabditis elegans eph receptor activates NCK and N-WASP,and inhibits Ena/VASP to regulate growth cone dynamics during axon guidance The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's Cancer The empirical power of rare variant association methods: Results from sanger sequencing in 1,998 individuals The mitochondrial chaperone protein TRAP1 mitigates α-synuclein toxicity The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms The role of glypicans in wnt inhibitory factor-1 activity and the structural basis of wif1's effects on wnt and hedgehog signaling The williams-beuren syndrome-a window into genetic variants leading to the development of cardiovascular disease Ultrafast evolution and loss of CRISPRs following a host shift in a novel wildlife pathogen,Mycoplasma Gallisepticum Upsetting the dogma: Germline selection in human males