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Genome-wide association study in East Asians identifies novel susceptibility loci for breast cancer
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نویسنده
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long j. ,cai q. ,sung h. ,shi j. ,zhang b. ,choi j.-y. ,wen w. ,delahanty r.j. ,lu w. ,gao y.-t. ,shen h. ,park s.k. ,chen k. ,shen c.-y. ,ren z. ,haiman c.a. ,matsuo k. ,kim m.k. ,khoo u.s. ,iwasaki m. ,zheng y. ,xiang y.-b. ,gu k. ,rothman n. ,wang w. ,hu z. ,liu y. ,yoo k.-y. ,noh d.-y. ,han b.-g. ,lee m.h. ,zheng h. ,zhang l. ,wu p.-e. ,shieh y.-l. ,chan s.y. ,wang s. ,xie x. ,kim s.-w. ,henderson b.e. ,le marchand l. ,ito h. ,kasuga y. ,ahn s.-h. ,kang h.s. ,chan k.y.k. ,iwata h. ,tsugane s. ,li c. ,shu x.-o. ,kang d.-h. ,zheng w.
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منبع
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plos genetics - 2012 - دوره : 8 - شماره : 2
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چکیده
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Genetic factors play an important role in the etiology of both sporadic and familial breast cancer. we aimed to discover novel genetic susceptibility loci for breast cancer. we conducted a four-stage genome-wide association study (gwas) in 19,091 cases and 20,606 controls of east-asian descent including chinese,korean,and japanese women. after analyzing 690,947 snps in 2,918 cases and 2,324 controls,we evaluated 5,365 snps for replication in 3,972 cases and 3,852 controls. ninety-four snps were further evaluated in 5,203 cases and 5,138 controls,and finally the top 22 snps were investigated in up to 17,423 additional subjects (7,489 cases and 9,934 controls). snp rs9485372,near the tgf-β activated kinase (tab2) gene in chromosome 6q25.1,showed a consistent association with breast cancer risk across all four stages,with a p-value of 3.8×10 -12 in the combined analysis of all samples. adjusted odds ratios (95% confidence intervals) were 0.89 (0.85-0.94) and 0.80 (0.75-0.86) for the a/g and a/a genotypes,respectively,compared with the genotype g/g. snp rs9383951 (p = 1.9×10 -6 from the combined analysis of all samples),located in intron 5 of the esr1 gene,and snp rs7107217 (p = 4.6×10 -7),located at 11q24.3,also showed a consistent association in each of the four stages. this study provides strong evidence for a novel breast cancer susceptibility locus represented by rs9485372,near the tab2 gene (6q25.1),and identifies two possible susceptibility loci located in the esr1 gene and 11q24.3,respectively.
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آدرس
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division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, department of biomedical sciences,seoul national university college of medicine,seoul, South Korea, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, department of biomedical sciences,seoul national university college of medicine,seoul, South Korea, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, shanghai center for disease control and prevention,shanghai, China, department of epidemiology,shanghai cancer institute,shanghai, China, department of epidemiology and biostatistics,nanjing medical university,nanjing, China, department of biomedical sciences,seoul national university college of medicine,seoul,south korea,department of preventive medicine,seoul national university college of medicine,seoul,south korea,cancer research institute,seoul national university college of medicine,seoul, South Korea, department of epidemiology and biostatistics,tianjin medical university cancer institute and hospital,tianjin, China, institute of biomedical sciences,academia sinica,taipei,taiwan,college of public health,china medical university,taichung, Taiwan, school of public health,sun yat-sen university,guangzhou, China, department of preventive medicine,keck school of medicine,university of southern california and norris comprehensive cancer center,los angeles,ca, United States, division of epidemiology and prevention,aichi cancer center research institute,nagoya, Japan, cancer epidemiology division,breast cancer center,national cancer center,goyang,south korea,department of surgery,asan medical center,university of ulsan college of medicine,ulsan, South Korea, department of pathology,li ka shing faculty of medicine,university of hong kong,hong kong, China, epidemiology and prevention division,research center for cancer prevention and screening,national cancer center,tokyo, Japan, shanghai center for disease control and prevention,shanghai, China, department of epidemiology,shanghai cancer institute,shanghai, China, shanghai center for disease control and prevention,shanghai, China, division of cancer epidemiology and genetics,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, shanghai center for disease control and prevention,shanghai, China, department of epidemiology and biostatistics,nanjing medical university,nanjing, China, department of epidemiology and biostatistics,nanjing medical university,nanjing, China, department of preventive medicine,seoul national university college of medicine,seoul, South Korea, cancer research institute,seoul national university college of medicine,seoul,south korea,department of surgery,seoul national university college of medicine,seoul, South Korea, center for genome science,korea national institute of health,seoul, South Korea, department of surgery,soonchunhyang university hospital,bucheon, South Korea, department of epidemiology and biostatistics,tianjin medical university cancer institute and hospital,tianjin, China, department of epidemiology and biostatistics,tianjin medical university cancer institute and hospital,tianjin, China, institute of biomedical sciences,academia sinica,taipei, Taiwan, institute of biomedical sciences,academia sinica,taipei, Taiwan, department of clinical oncology,queen mary hospital,hong kong, China, first affiliated hospital,sun yat-sen university,guangzhou, China, cancer center,sun yat-sen university,guangzhou, China, cancer research institute,seoul national university college of medicine,seoul,south korea,department of surgery,seoul national university college of medicine,seoul, South Korea, department of preventive medicine,keck school of medicine,university of southern california and norris comprehensive cancer center,los angeles,ca, United States, epidemiology program,cancer research center,university of hawaii,honolulu,hi, United States, division of epidemiology and prevention,aichi cancer center research institute,nagoya, Japan, department of surgery,nagano matsushiro general hospital,nagano, Japan, cancer epidemiology division,breast cancer center,national cancer center,goyang,south korea,department of surgery,asan medical center,university of ulsan college of medicine,ulsan, South Korea, cancer epidemiology division,breast cancer center,national cancer center,goyang,south korea,department of surgery,asan medical center,university of ulsan college of medicine,ulsan, South Korea, department of pathology,li ka shing faculty of medicine,university of hong kong,hong kong,china,department of obstetrics and gynecology,li ka shing faculty of medicine,university of hong kong,hong kong, China, department of breast oncology,aichi cancer center central hospital,nagoya, Japan, epidemiology and prevention division,research center for cancer prevention and screening,national cancer center,tokyo, Japan, department of biostatistics,vanderbilt university school of medicine,nashville,tn, United States, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, department of biomedical sciences,seoul national university college of medicine,seoul,south korea,department of preventive medicine,seoul national university college of medicine,seoul,south korea,cancer research institute,seoul national university college of medicine,seoul, South Korea, division of epidemiology,department of medicine,vanderbilt epidemiology center,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States
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Authors
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