plos genetics سال:2012 - دوره:8

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plos genetics
سال:2012 - دوره:8 - شماره:11

A Bacteriophage-Encoded J-Domain Protein Interacts with the DnaK/Hsp70 Chaperone and Stabilizes the Heat-Shock Factor σ32 of Escherichia coli A Combination of H2A.Z and H4 Acetylation Recruits Brd2 to Chromatin during Transcriptional Activation A Dominantly Acting Murine Allele of Mcm4 Causes Chromosomal Abnormalities and Promotes Tumorigenesis A Genome-Scale RNA-Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease A Germline Polymorphism of DNA Polymerase Beta Induces Genomic Instability and Cellular Transformation A Novel Human-Infection-Derived Bacterium Provides Insights into the Evolutionary Origins of Mutualistic Insect-Bacterial Symbioses A Spatial and Temporal Gradient of Fgf Differentially Regulates Distinct Stages of Neural Development in the Zebrafish Inner Ear A Targeted Glycan-Related Gene Screen Reveals Heparan Sulfate Proteoglycan Sulfation Regulates WNT and BMP Trans-Synaptic Signaling A Unified Method for Detecting Secondary Trait Associations with Rare Variants: Application to Sequence Data Antagonistic Gene Activities Determine the Formation of Pattern Elements along the Mediolateral Axis of the Arabidopsis Fruit Biochemical Diversification through Foreign Gene Expression in Bdelloid Rotifers Blockade of Pachytene piRNA Biogenesis Reveals a Novel Requirement for Maintaining Post-Meiotic Germline Genome Integrity C. elegans Dopaminergic D2-Like Receptors Delimit Recurrent Cholinergic-Mediated Motor Programs during a Goal-Oriented Behavior CELF4 Regulates Translation and Local Abundance of a Vast Set of mRNAs,Including Genes Associated with Regulation of Synaptic Function CNOT3 Is a Modifier of PRPF31 Mutations in Retinitis Pigmentosa with Incomplete Penetrance Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations Controls of Nucleosome Positioning in the Human Genome Cooperativity of Rb,Brca1,and p53 in Malignant Breast Cancer Evolution CtIP Is Required to Initiate Replication-Dependent Interstrand Crosslink Repair Deubiquitylation Machinery Is Required for Embryonic Polarity in Caenorhabditis elegans Discovering Thiamine Transporters as Targets of Chloroquine Using a Novel Functional Genomics Strategy Disruption of Chtf18 Causes Defective Meiotic Recombination in Male Mice Disruption of Mouse Cenpj,a Regulator of Centriole Biogenesis,Phenocopies Seckel Syndrome Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors Evolutionarily Ancient Association of the FoxJ1 Transcription Factor with the Motile Ciliogenic Program Genetic and Biochemical Dissection of a HisKA Domain Identifies Residues Required Exclusively for Kinase and Phosphatase Activities Genome Instability Caused by a Germline Mutation in the Human DNA Repair Gene POLB Genome,Functional Gene Annotation,and Nuclear Transformation of the Heterokont Oleaginous Alga Nannochloropsis oceanica CCMP1779 Genome-Wide Association Studies Reveal a Simple Genetic Basis of Resistance to Naturally Coevolving Viruses in Drosophila melanogaster Genomic Study of RNA Polymerase II and III SNAPc-Bound Promoters Reveals a Gene Transcribed by Both Enzymes and a Broad Use of Common Activators Genomic Variation and Its Impact on Gene Expression in Drosophila melanogaster HP1a Recruitment to Promoters Is Independent of H3K9 Methylation in Drosophila melanogaster Histone Methyltransferases MES-4 and MET-1 Promote Meiotic Checkpoint Activation in Caenorhabditis elegans Identification of the First ATRIP-Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR-ATRIP Seckel Syndrome Inference of Population Splits and Mixtures from Genome-Wide Allele Frequency Data Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression Interallelic and Intergenic Incompatibilities of the Prdm9 (Hst1) Gene in Mouse Hybrid Sterility Lamin B1 Polymorphism Influences Morphology of the Nuclear Envelope,Cell Cycle Progression,and Risk of Neural Tube Defects in Mice Lessons from Model Organisms: Phenotypic Robustness and Missing Heritability in Complex Disease Long Telomeres Produced by Telomerase-Resistant Recombination Are Established from a Single Source and Are Subject to Extreme Sequence Scrambling Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration Loss of the DNA Methyltransferase MET1 Induces H3K9 Hypermethylation at PcG Target Genes and Redistribution of H3K27 Trimethylation to Transposons in Arabidopsis thaliana Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma MIG-10 Functions with ABI-1 to Mediate the UNC-6 and SLT-1 Axon Guidance Signaling Pathways Mechanisms Employed by Escherichia coli to Prevent Ribonucleotide Incorporation into Genomic DNA by Pol V MicroRNA-Mediated Repression of the Seed Maturation Program during Vegetative Development in Arabidopsis Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations Mitosis in Neurons: Roughex and APC/C Maintain Cell Cycle Exit to Prevent Cytokinetic and Axonal Defects in Drosophila Photoreceptor Neurons Molecular,Physiological,and Motor Performance Defects in DMSXL Mice Carrying >1,000 CTG Repeats from the Human DM1 Locus Mutations in the Transcription Elongation Factor SPT5 Disrupt a Reporter for Dosage Compensation in Drosophila Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier Notch-Mediated Suppression of TSC2 Expression Regulates Cell Differentiation in the Drosophila Intestinal Stem Cell Lineage Plan B for Stimulating Stem Cell Division Plant Vascular Cell Division Is Maintained by an Interaction between PXY and Ethylene Signalling Polyadenylation-Dependent Control of Long Noncoding RNA Expression by the Poly(A)-Binding Protein Nuclear 1 Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites Population-Based Resequencing of APOA1 in 10,330 Individuals: Spectrum of Genetic Variation,Phenotype,and Comparison with Extreme Phenotype Approach RHOA Is a Modulator of the Cholesterol-Lowering Effects of Statin Regions of Homozygosity in the Porcine Genome: Consequence of Demography and the Recombination Landscape Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a Drosophila HSP Model Stimulation of Gross Chromosomal Rearrangements by the Human CEB1 and CEB25 Minisatellites in Saccharomyces cerevisiae Depends on G-Quadruplexes or Cdc13 The CPEB Protein Orb2 Has Multiple Functions during Spermatogenesis in Drosophila melanogaster The Contributions of Wobbling and Superwobbling to the Reading of the Genetic Code The Covariate's Dilemma The DNA Replication Factor RFC1 Is Required for Interference-Sensitive Meiotic Crossovers in Arabidopsis Thaliana The Genomes of the Fungal Plant Pathogens Cladosporium fulvum and Dothistroma septosporum Reveal Adaptation to Different Hosts and Lifestyles But Also Signatures of Common Ancestry The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove The Tumor Suppressor Gene Retinoblastoma-1 Is Required for Retinotectal Development and Visual Function in Zebrafish The Yeast SR-Like Protein Npl3 Links Chromatin Modification to mRNA Processing Tissue-Specific Regulation of Chromatin Insulator Function Transcription Elongation and Tissue-Specific Somatic CAG Instability Transcription Factor Oct1 Is a Somatic and Cancer Stem Cell Determinant Translational Control by the DEAD Box RNA Helicase belle Regulates Ecdysone-Triggered Transcriptional Cascades Trps1 and Its Target Gene Sox9 Regulate Epithelial Proliferation in the Developing Hair Follicle and Are Associated with Hypertrichosis Zcchc11 Uridylates Mature miRNAs to Enhance Neonatal IGF-1 Expression,Growth,and Survival dJun and Vri/dNFIL3 Are Major Regulators of Cardiac Aging in Drosophila